Staphylococcus aureus phage typing, antimicrobial susceptibility patterns and patient data correlated using a personal computer: advantages for monitoring the epidemiology of MRSA

Rossney, Angela S.; Pomeroy, H.; Keane, C. T.

doi:10.1016/0195-6701(94)90045-0

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…Although TATs are an attractive alternative, current formulations have not been successfully implemented for DFIs and can effectively combat drug‐resistant bacteria . Although these bacteriophages have been used to treat acute bacterial infections, no study has assessed their ability to ameliorate chronically infected wounds.…”

Section: Discussionmentioning

confidence: 99%

“…7 The addition of lytic bacteriophages may enhance the utility of TAT agents; they are safe for human use 10 and can effectively combat drug-resistant bacteria. 9 Although these bacteriophages have been used to treat acute bacterial infections, 16 no study has assessed their ability to ameliorate chronically infected wounds. Previously published studies have not assessed the effects of bacteriophage cocktails in chronic wounds; most examined outcomes after only a few hours of infection.…”

Section: Pig Modelmentioning

confidence: 99%

“…8 If appropriately complemented by adequate mechanical debridement, lytic bacteriophages could be efficient TAT agents in selected clinical environments because of their specificity and efficiency in lysing pathogenic bacteria, including those associated with multidrug resistance. 9 Moreover, they are not pathogenic in animals or humans, 10 Bacteriophage therapy is widely used and generally accepted as safe and beneficial in some parts of the world, 12 and recent trials in animal models have shown their potential to improve or heal bacterial skin infections following both internal 13 and external application. 14,15 However, there is little experimental evidence demonstrating that bacteriophages can cure chronic infections established for more than several hours.…”

Section: Introductionmentioning

confidence: 99%

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Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds

Mendes

Leandro

Côrte‐Real

et al. 2013

Wound Repair Regeneration

100

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Chronic wounds that fail to heal are a common complication of diabetes mellitus and the most common precipitating reason for nontraumatic lower limb amputation. Unfortunately, the bacterial species that cause these infections are becoming more resistant to antibiotics, making them increasingly difficult to treat. We assessed the feasibility of combating chronic bacterial infections with a topically delivered bacteriophage cocktail in two animal models of diabetes mellitus. Microbiological, planimetric, and histological parameters were compared in debrided infected wounds with or without topical bacteriophage treatment. We determined that bacteriophage treatment effectively decreased bacterial colony counts and improved wound healing, as indicated by smaller epithelial and dermal gaps, in Staphylococcus aureus and Pseudomonas aeruginosa infections but was not as effective against Acinetobacter baumannii. Although the improvements were more significant in the rodent model than in the porcine model, our results suggest that topically administered bacteriophage treatment may be effective in resolving chronic infections, especially when applied in conjunction with wound debridement. These findings have important implications for the feasibility of using topical antimicrobial therapies to safely treat chronic infections in diabetes mellitus patients.

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Section: Discussionmentioning

confidence: 99%

Section: Pig Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds

Mendes

Leandro

Côrte‐Real

et al. 2013

Wound Repair Regeneration

100

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“…Rates of resistance to other antimicrobials among UK MRSA isolates (recovered between 1993 and 1995) are shown in Table 6.4 (24) . In Ireland, the proportion of S. aureus isolates exhibiting resistance to methicillin rose from 20%, in 1991 to 27% in 1992 in one group of Dublin hospitals (26) . A second study reported a mean rate of 15.4% (range 4-38%) in 1993 from another group of hospitals (27) .…”

Section: Susceptibility Testing Resultsmentioning

confidence: 99%

“…Two previous studies have examined methicillin resistance in groups of hospitals in Ireland. In one study, the proportion of S. aureus isolates exhibiting resistance to methicillin increased from 20% in 1991 to 27% in 1992 (26) . In the second study in 1993 in another group of hospitals, the proportion of S. aureus that were resistant to methicillin was 15% (range 4% to 38%) (27) .…”

Section: Mrsa Bacteraemiamentioning

confidence: 99%

Control and the prevention of methicillin-resistant Staphylococcus aureus in hospitals in Ireland: North/South Study of MRSA in Ireland 1999

Burd

Humphreys

Glynn

et al. 2003

Journal of Hospital Infection

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Healthcare-Associated Infections

Wilcox

Spencer

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Your responsibility Your responsibilityThe recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals and practitioners are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or the people using their service. It is not mandatory to apply the recommendations, and the guideline does not override the responsibility to make decisions appropriate to the circumstances of the individual, in consultation with them and their families and carers or guardian.Local commissioners and providers of healthcare have a responsibility to enable the guideline to be applied when individual professionals and people using services wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with complying with those duties.Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.Healthcare-associated infections: prevention and control in primary and community care (CG139)

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Staphylococcus aureus phage typing, antimicrobial susceptibility patterns and patient data correlated using a personal computer: advantages for monitoring the epidemiology of MRSA

Cited by 9 publications

References 24 publications

Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds

Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds

Control and the prevention of methicillin-resistant Staphylococcus aureus in hospitals in Ireland: North/South Study of MRSA in Ireland 1999

Healthcare-Associated Infections

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