Staphylococcus aureus phage types and their correlation to antibiotic resistance

Mehndiratta, P L; Gur, Renu; Saini, Suman; Bhalla, Preena

doi:10.4103/0377-4929.72065

Cited by 25 publications

(27 citation statements)

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“…S. aureus strains can differ in their susceptibility profiles [49, 50]. In this study, we found that there was a high rate of resistance against penicillin and erythromycin.…”

Section: Discussionmentioning

confidence: 90%

Factors associated with Staphylococcus aureus nasal carriage and molecular characteristics among the general population at a Medical College Campus in Guangzhou, South China

Chen

Xie

et al. 2017

Ann Clin Microbiol Antimicrob

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BackgroundThe nasal cavity is the main colonization site of Staphylococcus aureus (S. aureus) in human body. Nasal carriage may be a strong risk factor for some serious infection. There was still limited information about the nasal carriage for S. aureus in south China.MethodsSought to determine the prevalence and molecular characteristics of S. aureus nasal carriage, 295 volunteers residing on a medicine campus were investigated and sampled the nasal cavity swab. Selected S. aureus isolates were carried through molecular analysis, including pulsed-field gel electrophoresis (PFGE), multilocus sequence analysis, staphylococcal cassette chromosome mec (SCCmec) and virulence gene detection.ResultsA total of 73 S. aureus isolates were recovered from separate subjects (24.7%, 73/295), with one methicillin-resistant S. aureus (MRSA) isolate (0.3%, 1/295). Among the 73 isolates, 71 isolates were successfully grouped into 13 pulsotypes by PFGE analysis, with profiles A and L the most prevalent; 12 sequence types (STs) were found among the 23 isolates which had similar drug resistant spectrum. ST59, ST188 and ST1 were the most prevalent, accounting for 17.4, 13.0 and 13.0% of all isolates, respectively. The MRSA isolate presented ST8-SCCmec III. 56.5% of isolates carried both the staphylococcal enterotoxin A (sea) and enterotoxin B (seb) genes. 83.6% of the S. aureus isolates were resistant to penicillin, all isolates were susceptible to quinupristin/dalfopristin, levofloxacin, teicoplanin and vancomycin. The most common risk factors for S. aureus carriage were being male, age ≤30 years, and nasal cavity cleaning habits.ConclusionsColonization by S. aureus was greater among male and young age (20–30 years) students and those with irregularity nasal cleaning. The S. aureus isolates selected were revealed into various sequence types and pulsotypes, indicating molecular heterogeneity among S. aureus isolates from the populations in the medical college in Guangzhou.

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“…S. aureus strains can differ in their susceptibility profiles [49, 50]. In this study, we found that there was a high rate of resistance against penicillin and erythromycin.…”

Section: Discussionmentioning

confidence: 90%

Factors associated with Staphylococcus aureus nasal carriage and molecular characteristics among the general population at a Medical College Campus in Guangzhou, South China

Chen

Xie

et al. 2017

Ann Clin Microbiol Antimicrob

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“…This test also revealed the high susceptibility of S. aureus to chloramphenicol, fosfomycin and fusidic acid. The antimicrobial susceptibility profile of S. aureus has been different in several previous reports and depended on the resistance profiles in both the community and healthcare worker groups [22,23]. Therefore, this data should be considered for inclusion in epidemiologic datasets for both areas.…”

Section: Discussionmentioning

confidence: 94%

Nasal carriage and antimicrobial susceptibility of Staphylococcus aureus among medical students at the HRH Princess Maha Chakri Sirindhorn Medical Center, Thailand: A cross sectional study

Treesirichod

Hantagool

Prommalikit

2013

Journal of Infection and Public Health

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“…This problem is aggravated by the tendency of MRSA for cross-infections. Heavy selection pressures toward acquiring MRSA infection are introduced by the intensive use of antibiotics, particularly cephalosporins (1st.4th generation) and carbapenem, to which organisms are resistant [1,2]. Methicillin resistance is a major risk factor for increased morbidity and mortality in S. aureus infections.…”

Section: Introductionmentioning

confidence: 99%

Unexpected Multidrug Resistance of Methicillin-ResistantStaphylococcus aureusin Urine Samples: A Single-Center Study

et al. 2014

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PurposeInfections of methicillin-resistant Staphylococcus aureus (MRSA) are becoming an increasingly concerning clinical problem. The aim of this study was to assess the development of MRSA in urine cultures in a major public university-affiliated hospital and the therapeutical and hygiene-related possibilities for reducing resistance.Materials and MethodsThis study included 243 samples from patients diagnosed with MRSA infection over a period of 6 years. An agar diffusion test measured the effects of antimicrobial agents against bacteria grown in culture. The analyses were based on the guidelines of the Clinical and Laboratory Standards Institute.ResultsA regression analysis was performed, which showed 100% resistance to the following antibiotics throughout the entire testing period: carbapenem, cephalosporin (1st-4th generation), penicillin G, aminopenicillin, β-lactamase, and isoxazolyl penicillin. However, a significant decrease in resistance was found for amikacin, gentamicin, clindamycin, levofloxacin, erythromycin, and mupirocin.ConclusionsMRSA showed a decreasing trend of antimicrobial resistance, except against carbapenem, cephalosporin (1st-4th generation), penicillin G, aminopenicillin, β-lactamase, and isoxazolyl penicillin, for which complete resistance was observed.

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Staphylococcus aureus phage types and their correlation to antibiotic resistance

Cited by 25 publications

References 0 publications

Factors associated with Staphylococcus aureus nasal carriage and molecular characteristics among the general population at a Medical College Campus in Guangzhou, South China

Factors associated with Staphylococcus aureus nasal carriage and molecular characteristics among the general population at a Medical College Campus in Guangzhou, South China

Nasal carriage and antimicrobial susceptibility of Staphylococcus aureus among medical students at the HRH Princess Maha Chakri Sirindhorn Medical Center, Thailand: A cross sectional study

Unexpected Multidrug Resistance of Methicillin-ResistantStaphylococcus aureusin Urine Samples: A Single-Center Study

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