“…The mechanism behind S aureus ’s CRS pathogenesis and tendency for poor prognosis has been described through various hypotheses, whether it be its biofilm‐forming capacities, 34 its intraepithelial presence, 35 its potential for immunity reduction, 36 or its impairment of epithelial repair, 7 among others. What remains evident is that S aureus is a strong marker for CRS outcome, both pre‐ and post‐ESS. 6 The benefit of adding AZI, and its capacity to influence S aureus clearance, is demonstrated clinically in this study, whereas our group also previously showed that the mechanism behind this effect may be associated with the CRS epithelium healing properties AZI has through its rho‐kinase inhibitor‐like properties, even in the presence of S aureus .…”