Staphylococcus aureus induces tolerance in human monocytes accompanied with expression changes of cell surface markers

Mm, Müller; Baldauf, Christian; Hornischer, Stella; Klassert, Tilman E.; Schneegans, Antony; Behnert, Andrea; Pletz, Mathias W.; Hagel, Stefan; Slevogt, Hortense

doi:10.3389/fimmu.2023.1046374

Cited by 4 publications

(1 citation statement)

References 65 publications

(44 reference statements)

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“…For example, members of the Bacteroidetes phylum decreased inflammation, neutrophil recruitment, and TLR2-mediated cytokine production compared with H. influenzae, in a mouse model [35]. Intranasal inoculation of Stafiloccoccus aureus led to monocyte recruitment to the lung that differentiated into AM-dampening IV-induced inflammatory responses [129]. S. pneumoniae, although known as a pathogen, is a typical commensal of the upper airways.…”

Section: Lung Immune Responses and Host-microbe Interactions During R...mentioning

confidence: 99%

Microbiota and Immunity during Respiratory Infections: Lung and Gut Affair

Marrella,

Nicchiotti,

Cassani

2024

IJMS

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Bacterial and viral respiratory tract infections are the most common infectious diseases, leading to worldwide morbidity and mortality. In the past 10 years, the importance of lung microbiota emerged in the context of pulmonary diseases, although the mechanisms by which it impacts the intestinal environment have not yet been fully identified. On the contrary, gut microbial dysbiosis is associated with disease etiology or/and development in the lung. In this review, we present an overview of the lung microbiome modifications occurring during respiratory infections, namely, reduced community diversity and increased microbial burden, and of the downstream consequences on host–pathogen interaction, inflammatory signals, and cytokines production, in turn affecting the disease progression and outcome. Particularly, we focus on the role of the gut–lung bidirectional communication in shaping inflammation and immunity in this context, resuming both animal and human studies. Moreover, we discuss the challenges and possibilities related to novel microbial-based (probiotics and dietary supplementation) and microbial-targeted therapies (antibacterial monoclonal antibodies and bacteriophages), aimed to remodel the composition of resident microbial communities and restore health. Finally, we propose an outlook of some relevant questions in the field to be answered with future research, which may have translational relevance for the prevention and control of respiratory infections.

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Section: Lung Immune Responses and Host-microbe Interactions During R...mentioning

confidence: 99%

Microbiota and Immunity during Respiratory Infections: Lung and Gut Affair

Marrella,

Nicchiotti,

Cassani

2024

IJMS

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Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis

Lin,

Yang,

Cheng

et al. 2024

Cell. Mol. Life Sci.

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Background Age-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of Staphylococcus aureus (S. aureus) infection in the bone tissue. However, the basis for age-associated decline in innate immune response upon S. aureus infection remains poorly understood. Results Our transcriptional data (GEO: GSE166522) from a mouse model of S. aureus osteomyelitis show up-regulated CXCL9 and CXCL10 (CXCL9/10), which is further confirmed in vitro and in vivo by the present study. Notably, monocytes are a main source for CXCL9/10 production in bone marrow upon S. aureus challenge, but this response declines in middle-aged mice. Interestingly, conditional medium of bone marrow monocytes from middle-aged mice has a strikingly decreased effect on bactericidal functions of neutrophils and macrophages compares with that from young mice. We further show that activation of CXCL9/10-CXCR3 axis between monocytes and macrophages/neutrophils promotes the bactericidal function of the cells, whereas blocking the axis impairs such function. Importantly, treatment with either exogenous CXCL9 or CXCL10 in a middle-aged mice model enhances, while pharmacological inhibition of CXCR3 in young mice model impairs, bacterial clearance and bone marrow structure. Conclusions These findings demonstrate that bone marrow monocytes act as a critical promotor of innate immune response via the CXLCL9/10-CXCR3 axis upon S. aureus infection, and that the increased susceptibility to S. aureus infection in skeleton in an aged host may be largely attributable to the declined induction of CXCR9/10 in monocytes.

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Renal Protective Effect and Clinical Analysis of Vitamin B6 in Patients With Sepsis

Wang,

Lu,

Feng

et al. 2024

Shock

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Objective To investigate the protective effect and possible mechanisms of vitamin B6 against renal injury in patients with sepsis. Methods A total of 128 patients with sepsis who met the entry criteria in multiple centres were randomly divided into experimental (intravenous vitamin B6 therapy) and control (intravenous 0.9% sodium chloride therapy) groups based on usual care. Clinical data, the inflammatory response indicators interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor (TNF-α) and endothelin-1 (ET-1), the oxidative stress response indicators superoxide dismutase, glutathione and malondialdehyde, and renal function (assessed by blood urea nitrogen [BUN], serum creatinine [SCr] and renal resistance index [RRI] monitored by ultrasound) were compared between the two groups. Results After 7 d of treatment, the IL-6, IL-8, TNF-α and ET-1 levels in the experimental group were significantly lower than those in the control group, the oxidative stress response indicators were significantly improved in the experimental group and the BUN, SCr and RRI values in the experimental group were significantly lower than those in the control group (p < 0.05). There was no statistical difference between the two groups in the rate of renal replacement therapy and 28 d mortality (p > 0.05). However, the ICU length of stay and the total hospitalisation expenses in the experimental group were significantly lower than those in the control group (p < 0.05). Conclusion The administration of vitamin B6 in the treatment of patients with sepsis attenuates renal injury, and the mechanism may be related to pyridoxine decreasing the levels of inflammatory mediators and their regulation by redox stress. Clinical trial registration: ClinicalTrials.gov Identifier: NCT06008223

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Staphylococcus aureus induces tolerance in human monocytes accompanied with expression changes of cell surface markers

Cited by 4 publications

References 65 publications

Microbiota and Immunity during Respiratory Infections: Lung and Gut Affair

Microbiota and Immunity during Respiratory Infections: Lung and Gut Affair

Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis

Renal Protective Effect and Clinical Analysis of Vitamin B6 in Patients With Sepsis

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