Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5‒Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma

Willerslev-Olsen, Andreas; Gjerdrum, Lise Mette Rahbek; Lindahl, Lise M.; Buus, Terkild Brink; Pallesen, Emil M.H.; Gluud, Maria; Bzorek, Michael; Nielsen, Boye Schnack; Kamstrup, Maria R.; Rittig, Anne Hald; Bonefeld, Charlotte M.; Krejsgaard, Thorbjørn; Geisler, Carsten; Koralov, Sergei B.; Litman, Thomas; Becker, Jürgen C.; Woetmann, Anders; Iversen, Lars; Ødum, Niels

doi:10.1016/j.jid.2021.01.038

Cited by 18 publications

(18 citation statements)

References 53 publications

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“…Staphylococcal enterotoxins contribute to disease progression in CTCL, namely, the alpha-toxin comprehensively blocks the cytotoxic killing of CTCL cells thus aiding in tumor evasion from programmed cell death [ 5 , 7 ]. S. aureus enterotoxins also induce the expression of oncogenic microRNA mIR-155 in malignant T cells [ 8 ]. MF lesions harboring S. aureus express Y-phosphorylated STAT5, and display enhanced miR-155 expression when compared to normal healthy skin [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…S. aureus enterotoxins also induce the expression of oncogenic microRNA mIR-155 in malignant T cells [ 8 ]. MF lesions harboring S. aureus express Y-phosphorylated STAT5, and display enhanced miR-155 expression when compared to normal healthy skin [ 8 , 9 ]. A particularly important and interesting association seen here is that when treated with antibiotics, there is decreased Y-phosphorylated STAT5 and miR-155 expression in lesioned skin in patients [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…MF lesions harboring S. aureus express Y-phosphorylated STAT5, and display enhanced miR-155 expression when compared to normal healthy skin [ 8 , 9 ]. A particularly important and interesting association seen here is that when treated with antibiotics, there is decreased Y-phosphorylated STAT5 and miR-155 expression in lesioned skin in patients [ 8 ]. A study in which patients were tested for the association of S. aureus w ith CTCL showed that 76% of the patients were positive for enterotoxin-producing S. aureus, thus indicating that paying heed to these toxigenic strains can potentially improve the outcomes in patients with CTCL [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Bacterial Infections in Cutaneous T-cell Lymphoma

Sateesh¹,

Bhagat²,

Thomas³

et al. 2022

Cureus

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Cutaneous T-cell lymphoma (CTCL) is a dermatologically manifesting immune cell disorder. We present a case of a 76-year-old female with a past medical history of CTCL, presenting with cellulitis of the left foot. After diagnosis of CTCL, the patient was admitted multiple times for treatment of cutaneous and soft-tissue infections with methicillin-resistant Staphylococcus aureus. Her recurrent infection with S. aureus had led to treatment for sepsis and a below-knee amputation on the right during prior hospitalizations. On this admission, the patient was treated with intravenous vancomycin and cefepime as in-patient and oral linezolid as out-patient. Recent articles show that patients with CTCL have an increased tendency to harbor S. aureus, which leads to recurrent infections. Additionally, evidence suggests that S. aureus toxins aid the progression of CTCL by helping the cancer to escape immune regulation. Our patient demonstrates this unique relationship between CTCL and S. aureus, and moreover, we make a case that S. aureus infection in CTCL, as compared to that in other dermatitis, should be better managed to not exacerbate the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Recurrent Bacterial Infections in Cutaneous T-cell Lymphoma

Sateesh¹,

Bhagat²,

Thomas³

et al. 2022

Cureus

View full text Add to dashboard Cite

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“…Interestingly, microbes have also been implicated in disease progression in CTCL ( 58 , 59 ). A recent study showed that S. aureus and its enterotoxins might enhance miR-155 expression and promote disease progression by stimulating the expression of post-transcriptional regulators of malignant T cells ( 21 ).…”

Section: Mir and Mfmentioning

confidence: 99%

“…In vitro experiments demonstrated that active antibiotic therapy may inhibit malignant T cell proliferation in advanced CTCL by inhibiting the staphylococcal enterotoxin (SE)-mediated bystander T cell response ( 35 ). Recent studies have further shown that this inhibitory effect may be achieved by partially reversing SE-induced pathological processes involving STAT5 and miR-155 ( 21 ). Notably, Staphylococcus aureus is also present to a greater extent in skin lesions in patients with MF than in patients with non-lesional or healthy skin.…”

Section: Mir and Mfmentioning

confidence: 99%

The Role of microRNA in Pathogenesis, Diagnosis, Different Variants, Treatment and Prognosis of Mycosis Fungoides

2021

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Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL), accounting for approximately 50% of all CTCLs. Although various molecular changes in MF have been described in existing studies, no obvious disease-specific changes have been found thus far. microRNAs (miRs) are short, noncoding RNA molecules that play roles in the post-transcriptional regulation of oncogenes and tumor suppressor genes in various diseases. Recently, there has been rapidly expanding experimental evidence for the role of miRs in the progression, early diagnosis, prognosis prediction for MF. Efforts to improve early diagnosis and develop personalized therapy options have become more important in recent years. Here, we provide an overview and update of recent advances regarding miRs associated with MF. Furthermore, we provide insights into future opportunities for miR-based therapies.

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