2020
DOI: 10.3390/ijms21197061
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Staphylococcus aureus Host Tropism and Its Implications for Murine Infection Models

Abstract: Staphylococcus aureus (S. aureus) is a pathobiont of humans as well as a multitude of animal species. The high prevalence of multi-resistant and more virulent strains of S. aureus necessitates the development of new prevention and treatment strategies for S. aureus infection. Major advances towards understanding the pathogenesis of S. aureus diseases have been made using conventional mouse models, i.e., by infecting naïve laboratory mice with human-adapted S.aureus strains. However, the failure to transfer cer… Show more

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Cited by 23 publications
(18 citation statements)
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References 240 publications
(313 reference statements)
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“…Humanized mice with engrafted human immune cells may advance the translatability of mouse models of S. aureus infection ( Allen et al, 2019 ). Virulence of human-targeted toxins (such as PVL) is more likely to be revealed in mice with human hematopoietic cells ( Mrochen et al, 2020 ). Improved animal models may help determine which therapeutics should advance to clinical trials as antivirulence therapies continue to be explored.…”
Section: Discussionmentioning
confidence: 99%
“…Humanized mice with engrafted human immune cells may advance the translatability of mouse models of S. aureus infection ( Allen et al, 2019 ). Virulence of human-targeted toxins (such as PVL) is more likely to be revealed in mice with human hematopoietic cells ( Mrochen et al, 2020 ). Improved animal models may help determine which therapeutics should advance to clinical trials as antivirulence therapies continue to be explored.…”
Section: Discussionmentioning
confidence: 99%
“…CC130. CC1956) lacking human-specific virulence factors, such as superantigens and the IEC [Mrochen et al, 2018b[Mrochen et al, , 2020. Interestingly, laboratory mice also carry a large variety of S. aureus CCs, most of which likely originate from the human population but also lack Sa3int phages.…”
Section: Wild Rodents and Mice From Animal Facilitiesmentioning
confidence: 99%
“…However, even though animal models remain necessary to decipher fundamental host-pathogen interactions and even though many potentially promising S. aureus anti-toxin therapeutics exist, most have failed in human trials or have not been tested. Therefore, the development of humanized mice with engrafted human immune cells for instance could help improve the translatability of animal investigations to human trials in the future [183][184][185]. This strategy will improve animal models, thus helping in deciding which treatments should proceed to clinical trials.…”
Section: Discussionmentioning
confidence: 99%