Staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris

Delost, Gregory R.; Delost, Maria E.; Armile, James; Lloyd, J. H.

doi:10.1016/j.jaad.2015.11.025

Cited by 20 publications

(11 citation statements)

References 20 publications

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“…With increasing evidence of bacterial resistance and the negative effects of oral antibiotics, the American Academy of Dermatology recommends the use of systemic antibiotics for only about 3 months. [10][11][12] As clinicians look for other medications to effectively and safely treat acne for longer periods, our study's findings provide impactful and clinically relevant information for practising dermatologists and their patients.…”

Section: Adverse Effectsmentioning

confidence: 83%

Treatment of acne with spironolactone: a retrospective review of 395 adult patients at Mayo Clinic, 2007–2017

Roberts

Nowsheen

Davis

et al. 2020

Acad Dermatol Venereol

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Background Few large studies have assessed spironolactone treatment of adult female acne. Objectives To explore the role of spironolactone in the treatment of adult female acne. Methods We performed a retrospective case series assessing the efficacy of spironolactone treatment of a cohort of women evaluated at Mayo Clinic in Rochester, Minnesota, from 2007 through 2017. Results In total, 395 patients (median age, 32 years) received a median spironolactone dose of 100 mg daily. Approximately two‐thirds of patients (66.1%) had a complete response; 85.1% had a complete response or a partial response greater than 50%. Median times to initial response and maximum response were 3 and 5 months. Efficacy was observed across all severity subtypes of acne, including those with papulopustular and nodulocystic acne. Patients received long‐term treatment with spironolactone (median duration, 13 months) and had few adverse effects. Conclusions Spironolactone is a safe and effective treatment of acne for women.

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Section: Adverse Effectsmentioning

confidence: 83%

Treatment of acne with spironolactone: a retrospective review of 395 adult patients at Mayo Clinic, 2007–2017

Roberts

Nowsheen

Davis

et al. 2020

Acad Dermatol Venereol

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“…The antimicrobial activity of the proposed formulation was assessed against Gram-positive, Gram-negative, and fungal strains. These strains have been chosen for the following reasons: (i) they are indicated by the US Pharmacopeia for antimicrobial effectiveness testing [ 14 ]; (ii) there are many cases of complications due to P. aeruginosa and S. aureus following long-term antibacterial treatment in acne patients, which are generally underestimated, since correct sampling and bacteriology is rarely performed by clinicians [ 15 , 16 , 17 ]; (iii) moreover, long-term use of antibiotics in the treatment of acne vulgaris can lead to the emergence of antimicrobial resistance both in Propionibacterium acnes and other bacterial species, with systemic consequences [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds

Saviuc

Ciubuca

G³

et al. 2017

IJMS

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The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i.e., eugenol, β-pinene, eucalyptol, and limonene) and anti-inflammatory agents for potential use in the topical treatment of acne and other skin infections. The optimal antimicrobial combinations selected in this study were eugenol/β-pinene/salicylic acid and eugenol/β-pinene/2-phenoxyethanol/potassium sorbate. The possible mechanisms of action revealed by flow cytometry were cellular permeabilization and inhibition of efflux pumps activity induced by concentrations corresponding to sub-minimal inhibitory (sub-MIC) values. The most active antimicrobial combination represented by salycilic acid/eugenol/β-pinene/2-phenoxyethanol/potassium sorbate was included in a cream base, which demonstrated thermodynamic stability and optimum microbiological characteristics.

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“…This may be preferable to oral antibiotics in light of public health antibiotic stewardship and concerns of antimicrobial resistance. [10][11][12] Spironolactone could be trialed, and if efficacy is not achieved within 6 months, isotretinoin could then be pursued.…”

Section: Discussionmentioning

confidence: 99%

Use of spironolactone to treat acne in adolescent females

Roberts

Nowsheen

Davis

et al. 2020

Pediatric Dermatology

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Spironolactone is commonly used in dermatology for acne vulgaris treatment in women due to its anti-androgen effects. Recent studies of spironolactone have shown promising results for its use for acne in adult women. 1-6 However, studies examining the efficacy of spironolactone for pediatric patients are lacking. In this retrospective review, we studied the effectiveness and safety of spironolactone for acne treatment in female adolescents. 2 | ME THODS The criteria and methods for the current study are similar to our recent report on the use of spironolactone in adult females. 6 Upon receiving approval from Mayo Clinic's Institutional Review Board, an electronic search of institutional medical records (January 1, 2007, through December 31, 2017) was performed to identify patients younger than 21 years of age treated at Mayo Clinic. Inclusion criteria included the following: females with a diagnosis of acne made

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Staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris

Cited by 20 publications

References 20 publications

Treatment of acne with spironolactone: a retrospective review of 395 adult patients at Mayo Clinic, 2007–2017

Treatment of acne with spironolactone: a retrospective review of 395 adult patients at Mayo Clinic, 2007–2017

Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds

Use of spironolactone to treat acne in adolescent females

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