Staphylococcal Population Changes in Experimentally Infected Mice: Infection with Suture-Adsorbed and Unadsorbed Organisms Grown in Vitro and in Vivo

Taubler, James H.; Kapral, Frank A.

doi:10.1093/infdis/116.3.257

Cited by 12 publications

(13 citation statements)

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“…This was confirmed in animal studies [4][5][6][7]. The mechanism underlying this enhancement of susceptibility to infection is still incompletely understood.…”

mentioning

confidence: 65%

Biomaterial‐Associated Persistence ofStaphylococcus epidermidisin Pericatheter Macrophages

Boelens¹,

Dankert²,

Murk³

et al. 2000

J INFECT DIS

108

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Biomaterial surfaces may be modified to reduce bacterial adhesion. The susceptibility in mice to Staphylococcus epidermidis infection in tissue surrounding the commonly used catheter materials-silicon elastomer (SE), polyamide (PA), and their surface-modified polyvinylpyrrolidone (PVP)-grafted derivatives, SE-PVP and PA-PVP, respectively-was assessed. Abscesses developed around SE-PVP. Around SE, PA, and PA-PVP catheters, no signs of infection were observed, although mice carrying PA-PVP developed septicemia after 14-21 days. S. epidermidis was cultured from the tissue surrounding PA-PVP segments. Cells around PA-PVP segments containing large numbers of bacteria were identified as macrophages by use of immunohistochemistry and electron microscopy. This persistence of intracellular bacteria was also observed around SE-PVP, SE, and PA catheters, although to a lesser extent. The cytokine profiles around the 4 materials were different. Implanted biomaterial induces an inflammatory response favorable to the persistence of S. epidermidis. Intracellular persistence of bacteria inside macrophages may be a pivotal process in the pathogenesis of biomaterial-associated infection.

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“…This was confirmed in animal studies [4][5][6][7]. The mechanism underlying this enhancement of susceptibility to infection is still incompletely understood.…”

mentioning

confidence: 65%

Biomaterial‐Associated Persistence ofStaphylococcus epidermidisin Pericatheter Macrophages

Boelens¹,

Dankert²,

Murk³

et al. 2000

J INFECT DIS

108

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show abstract

“…21 Similar results were obtained in several animal studies. [22][23][24][25] It was concluded that biomaterials enhanced susceptibility to infection and that bacteria were required to induce abscesses. The present study extends these observations.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous abscess formation around catheters induced by viable and nonviableStaphylococcus epidermidis as well as by small amounts of bacterial cell wall components

Boelens

Zaat

Meeldijk

et al. 2000

J. Biomed. Mater. Res.

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The use of catheters is often complicated by infection, mainly due to Staphylococcus epidermidis. Recently, a novel poly(vinylpyrrolidone)-grafted silicone elastomer catheter (SEpvp) was introduced. Less bacteria adhered to SEpvp than to conventional SE catheters in vitro. The frequency of S. epidermidis infection associated with SEpvp and SE was assessed in a rabbit model. Unexpectedly, abscesses were induced by the injection of low numbers of S. epidermidis along subcutaneously inserted SEpvp. No abscesses were seen around SE, even when very high numbers of S. epidermidis were injected. This bioincompatibility reaction observed around the SEpvp was independent of the host, bacterial strain, and method of inoculation. Abscesses were also induced by nonviable S. epidermidis and by bacterial cell wall components. Because these incompatibility reactions were not observed in the absence of bacteria, biocompatibility testing should include experiments in which the inflammatory effects of the combination of catheter and (non)viable bacteria are tested.

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“…They reported “orange size” infectious tumors and high fever reactions in patients with the sutures but also an understandable difficulty to recruit new volunteering patients to further test foreign body reactions. Their work inspired animal studies reporting minor or no problems when mice were injected subcutaneously with staphylococci in contrast to a demonstrated bacterial multiplication at the suture sites …”

Section: Introductionmentioning

confidence: 99%

Is Marginal Bone Loss around Oral Implants the Result of a Provoked Foreign Body Reaction?

Albrektsson

Dahlin

Jemt

et al. 2013

Clin Implant Dent Rel Res

274

258

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Staphylococcal Population Changes in Experimentally Infected Mice: Infection with Suture-Adsorbed and Unadsorbed Organisms Grown in Vitro and in Vivo

Cited by 12 publications

References 0 publications

Biomaterial‐Associated Persistence ofStaphylococcus epidermidisin Pericatheter Macrophages

Biomaterial‐Associated Persistence ofStaphylococcus epidermidisin Pericatheter Macrophages

Subcutaneous abscess formation around catheters induced by viable and nonviableStaphylococcus epidermidis as well as by small amounts of bacterial cell wall components

Is Marginal Bone Loss around Oral Implants the Result of a Provoked Foreign Body Reaction?

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