Staphylococcal enterotoxin IgE sensitization in late‐onset severe eosinophilic asthma in the elderly

Abstract

This is the first report on the significant associations of SE-IgE sensitization with late-onset asthma in the elderly, particularly severe eosinophilic asthma with CRS comorbidity. Our findings indicate a potential implication of SE in the high morbidity burden of elderly asthma and suggest clues to the pathogenesis of severe late-onset eosinophilic asthma in the elderly.

Omalizumab could be effective in children with severe eosinophilic non‐allergic asthma

“…9 This phenotype of asthma is very similar to our cohort and this might explain the effectiveness of omalizumab with respect to enterotoxin-IgE sensitization. Further studies are required to confirm this hypothesis.…”

“…9 We divided patients in the development dataset into two groups (severe and non-severe cases) by TS/Pro = 50 on the basis of our clinical practice. At this point or lower, patients could start ingestion of at least 2 g of udon noodle at home safely and feasibly.…”

Clinical phenotypes in asthma during childhood

“…12,17 • Early sensitization to multiple allergens, but also molecular allergens, conveys a higher risk of asthma exacerbations. [33][34][35][36][37] • Patients with the persistent eosinophilic phenotype have a greater risk of asthma exacerbations. [33][34][35][36][37] • Patients with the persistent eosinophilic phenotype have a greater risk of asthma exacerbations.…”

Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy

“…Finally, Song et al show that in older patients with asthma (≥65 years and many specifically with chronic rhinosinusitis and nasal polyps), IgE to staphylococcal enterotoxin was associated with an increased risk of more severe disease and disease associated with sputum eosinophilia . In this elderly late‐onset group, sensitization to these specific antigens seems to be particularly important as has been shown in younger severe asthmatics.…”