Staphylococcal Endocarditis and Glomerulonephritis in Dogs

Highman, Benjamin; Altland, Paul D.; Roshe, Joseph

doi:10.1161/01.res.7.6.982

Cited by 16 publications

(6 citation statements)

References 5 publications

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“…Many other reports now exist, and the literature of canine glomerulonephritis has been enlarged [2, 28, Forty-two cases of canine glomerulonephritis were studied by conventional light microscopy and, in many instances, by electron microscopy and immunofluorescence [68]. The major lesion was characterized by proliferation of mesangial cells with, in some cases, exudation of fibrinoid material into Bowman's space and parietal 35,40,41,46,56,67,[70][71][72][73][74], 771. epithelial proliferation. Six cases also had features resembling mesangiocapillary glomerulonephritis of man.…”

Section: Clomerulonephritis In Dogsmentioning

confidence: 99%

Comparative Pathology of Glomerulonephritis in Animals

Slauson

Lewis

1979

Vet Pathol

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Abstract. Glomerulonephritis constitutes an important category of renal diseases in animals and has been recognized with increasing frequency in the last decade. We report here the comparative morphologic aspects of glomerulonephritis as a naturally occurring disease of animals. We briefly review the immunopathogenesis of glomerulonephritis. The morphology of renal lesions occurring in glomerulonephritis in dogs, cats, cattle, sheep, horses and swine has been reviewed with emphasis on the range and specificity of various glomerular lesions and on the comparison of lesions between various species. A distinction was made between glornerulonephritis as a primary disease entity and glomerulonephritis associated with other disease processes. Primary idiopathic glomerulonephritis occurred in all species but was most commonly recognized as a clinically important disease in dogs and cats. Glomerulonephritis also occurred in association with other diseases such as equine infectious anemia, chronic hog cholera, canine pyometra, dirofilariasis, feline leukemia virus infection and canine systemic lupus erythematosus.Glomerulonephritis is responsible for substantial morbidity and mortality in many species of animals. Although the cause is basically unknown, it is a disease generally thought to result from the interaction of immunologic and inflammatory reactants at a fixed tissue site (the glomeruli) with subsequent loss of structural and functional integrity of the injured tissues. It is not the purpose of this paper to detail the pathogenesis of glomerulonephritis. For a better understanding of the disease as it occurs in animals, however, it will be useful to review briefly what is known about the pathways potentially leading to glomerular injury [25, 61, 71, 73, 77, 82, 831. Two major immunologic mechanisms of glomerular injury have been identified. In one, antibodies react with antigens in the glomerular basement membrane. In the other, antibodies react with nonglomerular antigens in the circulation to form immune complexes that are deposited in the glomerulus. With conventional light microscopy, it is difficult to infer the pathogenetic mechanisms responsible for glomerulonephritis from the histologic lesion. Differentiating these two mechanisms usually requires fluorescence and electron microscopy. Glomerular lesions induced by soluble immune complexes have characteristic discrete, interrupted, focal deposits of host IgG and complement when examined by fluorescence microscopy. In contrast, the fluorescence staining pattern of glomeruli injured by anti-glomerular basement membrane antibody is uniform, smooth and linear. To further implicate anti-glo- 135

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Section: Clomerulonephritis In Dogsmentioning

confidence: 99%

Comparative Pathology of Glomerulonephritis in Animals

Slauson

Lewis

1979

Vet Pathol

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“…Gutman et al, (1972) reported a diffuse proliferative glomerulonephritis as the most typical renal lesion of SBE in their patients although also described a 'focal embolic' lesion. These workers were able to detect IgG and complement in the glomerular basement membrane and explain the glomerulonephritis as an immune complex phenomenon arising either from antibody/antigen reactions involving the infecting bacterial antigens, as has been shown experimentally in dogs with staphylococcal endocarditis (Highman, Altland & Roshe, 1959), or from similar reactions involving the patient's own tissue antigens reacting with circulating autoantibodies as is thought to occur in human SLE (Cochrane & Koffler, 1973;Koffler, 1974;Winfield, Koffler & Kunkel, 1975). However, there was no evidence of immune complex deposits in the kidneys of either of the two dogs reported here.…”

Section: Discussionmentioning

confidence: 84%

Bacterial endocarditis with polyarthritis in two dogs associated with circulating autoantibodies

Bennett

Gilbertson

Grennan

1978

J of Small Animal Practice

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“…Bei der akuten Post-Streptokokken-Glomerulonephritis des Menschen findet sich wenige Wochen nach der Infektion eine diffuse, panglomerulare, proliferative Glomerulonephritis (TORNROTH, 1976 HIGHMAN und Mitarbeiter (1956, 1958, 1959 (HAHN u. Mitarb., 1970).…”

Section: Kontrollen (N = 4 )unclassified

“…Von MARCATO (1966) wird eine spontan aufgetretene Streptokokkeninfektion eines Hundes mit akuter Glomerulonephritis beschrieben. Uber experimentell induzierte Streptokokken-Glomerulonphritiden bei Hunden berichten DUVAL (1931), KO (1931), SIMONDS und Mitarbeiter (1946), LILLEHEI und Mitarbeiter (1951) und HIGHMAN und Mitarbeiter (1956;1958;1959).…”

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Experimentelle Infektionen von Hunden mit Streptokokken, Pasteurellen und Mykoplasmen*

Müller‐Peddinghaus

Kirpal

Amtsberg

et al. 2010

Zentralblatt Für Veterinärmedizin Reihe B

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Zusammenfassung Experimentelle Infektionen von jungen Hunden (n = 25) mit verschiedenen Streptokokkenstämmen (Lancefield‐Gruppe A, n = 2; G, n = 11; L, n = 4; N, Sc. saccharolactis, n = 1) und anderen Erregern (Pasteurella multocida und Mykoplasmen; n = 3), einschließlich 4 Kontrolltieren, sollten klären, ob sie der Post‐Streptokokken‐Glomerulonephritis des Menschen vergleichbare Glomerulopathien verursachen würden. Die Hunde wurden bis zu 11 Wochen lang mehrfach intravenös oder intraperitoneal mit den genannten Infektionserregern infiziert. Eine stichprobenweise semiquantitative und qualitative (SDS‐PAGE) Harneiweißanalyse erbrachte keinen Hinweis auf Glomerulopathien. Histopathologisch relevante glomeruläre Läsionen konnten an paraffinhistologischem Material, an 1 μm dicken methenaminsilbergefärbten Metacrylatschnitten und immunfluoreszenzhistologisch mit FITC‐konjugierten Antiseren gegen canines IgG, IgM, IgA, C 3 und Fibrin (‐ogen) nicht nachgewiesen werden. Die vorliegenden Befunde und die anderen Untersucher lassen den Schluß zu, daß es eine diffuse, akute oder chronisch‐progrediente Glome‐rulopathie nach Streptokokkeninfektion, von ähnlicher klinischer Bedeutung wie die Post‐Streptokokken‐Glomerulonephritis des Menschen, beim Hund nicht gibt. Summary Experimental infection of dogs with Streptococci, Pasteurella and Mycoplasma 2. Immunopathological renal findings Experimental infections of young dogs (n = 25) with various strains of streptococci (Lancefield group A, n = 2; G, n = 11; L, n = 4; Sc. saccharolactis, n = 1) and other organisms (Pasteurella multocida and mycoplasma; n = 3), including control 4 animals, were carried out to determine whether they cause in dogs a glomerulopathy comparable with post‐streptococcal glomerulonephritis in man. The dogs received for up to 11 weeks repeated intravenous or intraperitoneal injections of the various organisms. Semi‐quantitative and qualitative analysis of urinary proteins (SDS polyacrylamide gel electrophoresis) showed no evidence of glomerulonephropathy. No histologically relevant glomerular lesions were revealed in paraffin embedded sections, 1 μm metacrylate sections stained with methenamine silver, or by immunofluorescence histology with FITC‐conjugated antisera against canine IgG, IgM, IgA, C3 and fibrin(‐ogen). These findings and those of other workers show that the dog does not develop after streptococcal infection a diffuse, acute or chronic progressive glomerulonephropathy with similar clinical features to poststreptococcal glomerulonephritis in man. Résumé Infections expérimentales de chiens avec des streptocoques, des pasteurelles et des mycoplasmes II. Résultats immunopathologiques des reins On a cherché à savoir si des infections expérimentales de jeunes chiens (n = 25) avec différentes souches de streptocoques (groupe de Lancefield A, n = 2; G, n = 11; L, n = 4; N, Sc. saccharolactis, n = 1) et d'autres germes (Pasteurella multocida et mycoplasmes, n = 3), pouvaient provoquer des glomérulopathies comparables à la glomérulonéphrite post‐streptoc...

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Staphylococcal Endocarditis and Glomerulonephritis in Dogs

Cited by 16 publications

References 5 publications

Comparative Pathology of Glomerulonephritis in Animals

Comparative Pathology of Glomerulonephritis in Animals

Bacterial endocarditis with polyarthritis in two dogs associated with circulating autoantibodies

Experimentelle Infektionen von Hunden mit Streptokokken, Pasteurellen und Mykoplasmen*

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