Stanowisko Polskiego Towarzystwa Endokrynologicznego, Polskiego Towarzystwa Ginekologów i Położników oraz Polskiego Towarzystwa Endokrynologii Ginekologicznej w sprawie diagnostyki i leczenia zespołu policystycznych jajników

Milewicz, Andrzej; Kudła, Marek; Spaczyński, Robert; Dębski, Romuald; Męczekalski, Błażej; Wielgoś, Mirosław; Ruchała, Marek; Małecka-Tendera, Ewa; Kos–Kudła, Beata; Jędrzejuk, Diana; Zachurzok, Agnieszka

doi:10.5603/ep.2018.0046

Cited by 18 publications

(23 citation statements)

References 52 publications

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“…Polycystic ovary syndrome (PCOS) is the most common cause of hyperandrogenism in girls and women. According to the commonly used Rotterdam criteria, the incidence of PCOS in women ranges from 3% to 26%, and in adolescents it is about 8% [1][2][3]. Clinically hyperandrogenism is manifested by severe acne, scanty or infrequent menstruations, and male hirsutism.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Overweight and Obesity Related to Diet and Disordered Eating Attitudes in Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Mizgier¹,

Jarząbek-Bielecka

Opydo-Szymaczek

et al. 2020

JCM

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Background: We aimed to find the difference between girls with clinical features of Polycystic ovary syndrome (PCOS), divided into two groups: Overweight/obesity (Ov/Ob) and normal weight (N), related to diet, disordered eating attitudes (DEA), metabolic and hormonal differences, and to identify the risk factors of being overweight or obese. Methods: Seventy-eight adolescents with PCOS, aged 14–18 years, were divided into Ov/Ob and N groups. Patients underwent blood tests for determination of follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone, DHEA-S, estradiol, of sex hormone-binding globulin (SHBG), fasting glucose, insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and lipid profile. Nutrition was evaluated using a 3-day food record. To examine the level of DEA, the Eating Attitudes Test-26 (EAT-26) was used. We defined an EAT-26 score ≥20 as positive for DEA. Logistic regression was carried out to identify the independent predictors of being overweight and obese. Results: An increase of 10 g in plant protein intake decreased the probability of being overweight and of obesity (OR = 0.54; p = 0.036). EAT-26 score ≥20 was correlated with a 7-fold (OR = 6.88; p = 0.02) increased odds of being overweight or of obesity. Conclusion: Being overweight and obesity in adolescents with PCOS may be associated with DEA and the type and amount of protein intake.

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Section: Introductionmentioning

confidence: 99%

Risk Factors of Overweight and Obesity Related to Diet and Disordered Eating Attitudes in Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Mizgier¹,

Jarząbek-Bielecka

Opydo-Szymaczek

et al. 2020

JCM

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“…Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting approximately 6-13% of women of reproductive age [1], characterised by reproductive and metabolic disorders. According to the Androgen Excess Society (AES), the diagnosis of PCOS is based on the fulfilment of criteria, including clinical or biochemical symptoms of hyperandrogenism, and the coexistence of one of the two following symptoms: oligo-ovulation/anovulation or polycystic ovarian picture in ultrasound examination [2].…”

Section: Introductionmentioning

confidence: 99%

The value of the free androgen index depends on the phenotype of polycystic ovary syndrome — a single-centre experience

Ożga

Krzyczkowska-Sendrakowska

Hubalewska‐Dydejczyk

et al. 2019

Endokrynologia Polska

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Introduction: The free androgen index (FAI) values differ among patients with polycystic ovarian syndrome; however, the differences are not fully understood or known. The aim of the study was to evaluate FAI in women with polycystic ovary syndrome (PCOS) in regard to the phenotype of the PCOS and insulin resistance status. Material and methods: Anthropometric, hormonal, and biochemical parameters were assessed in 312 recruited women with PCOS. The FAI values were calculated in the reproductive and metabolic phenotypes of PCOS in groups of insulin resistance status based on the homeostasis model assessment-insulin resistance (HOMA-IR) > 2.0 or fasting insulin (FI) > 10 mmol/L. To test the relationship between individual variables, Spearman's correlation analysis, the Kolmogorov-Smirnov test, and Student's t-test were used. Results: The correlation between FAI values and HOMA-IR and FI was 0.42 and 0.47, respectively, in PCOS patients. A two fold higher FAI value was observed in metabolic PCOS phenotype when compared to the reproductive one (8.51 ± 5.56 vs. 4.40 ± 2.45 for HOMA-IR and 8.73 ± 6.09 vs. 4.31 ± 3.39 for FI, respectively; p < 0.05). Conclusions: PCOS patients are not a homogenous group in terms of FAI value. Patients with metabolic PCOS phenotype are characterised by twofold higher FAI values compared with reproductive PCOS phenotype. Further studies on the metabolic and androgenic status of different types of PCOS phenotypes should be carried out.

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“…Крім того, важливу роль у патогенезі СПКЯ відіграє контрольований ароматазами позагонадний синтез в адипоцитах андрогенів та естрогенів. З іншого боку, ГІ інгібує синтез глобуліну, що зв'язує стероїдні гормони, а це збільшує концентрацію біологічно активних фракцій вільних андрогенів, що призводить до порушення фолікулогенезу в яєчниках [13,14]. Отже, порушення внутрішньоклітинних ефектів інсуліну при СПКЯ, ймовірно, є характерним для адипоцитів, скелетних м'язів, фібробластів шкіри, клітин теки і гранульози яєчників.…”

Section: міждисциплінарний консиліумunclassified

“…Сьогодні близько 1/5 населення планети страждає на неалкогольну жирову хворобу печінки (НАЖХП) -найчастіше захворювання печінки в розвинутих країнах, ризик якого значно збільшується за наявності ожиріння та ЦД (75-90%) [14,15]. Розповсюдженість стеатогепатозу на фоні СПКЯ варіює від 32,9% у Китаї та 55% в Америці до 73,3% у Бразилії, що може бути пов'язано зі спадковими та етнічними факторами, а також особливостями способу життя і харчування.…”

Section: міждисциплінарний консиліумunclassified

Polycystic ovary syndrome: approach to correction of metabolic disorders

Калугина

Татарчук

2020

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Objective: to study the reliability of working hypothesis about positive effect of plant adaptogens with hepatoprotective and anti-inflammatory activity in correction of metabolic complications of polycystic ovary syndrome (PCOS) and to study the possibility of including schisandrin into treatment, choice of which is due to its properties to improve tissue sensitivity to insulin, hepatoprotective, hypolipidemic, anti-inflammatory and antioxidant effects.Materials and methods. A comparative prospective study of 60 patients aged 18–38 years with PCOS (phenotype A) was carried out. Criteria for inclusion in the study were: a confirmed diagnosis with increased ovaries and oligo-/anovulation, increased level of ovarian androgens; body mass index (BMI) from 25 to 30.1 kg/m2. All women underwent a general clinical examination evaluating anthropometric parameters and BMI, the presence of clinical manifestations of hyperandrogenism (hirsutism and androgenic dermatopathy) on a Ferriman-Gallwey scale, ultrasound of the genital organs, assessment of progesterone and insulin resistance based on the NOMA index on the 22–24th day of the menstrual cycle. Рatients were divided into 2 equal groups depending on the therapy: women in the main group were prescribed schisandrin 1 tablet (250 mg) three times a day for 12 weeks, patients in the control group received recommendations on diet and physical load.Results. The resulting course of treatment with schisandrin showed restoration of regular menstrual cycles in 40% of patients (versus 16.6% at the beginning of the study) due to a 1.4-fold increase in progesterone level, improvement of skin condition, BMI normalization. A positive effect of treatment on the metabolic status was also noted: a significant decrease in HOMA indices was observed, and transaminases levels were normalized.Conclusions. For a comprehensive examination of patients with PCOS, especially those who are overweight and obese, it is necessary to include a HOMA index assessment, functional liver tests, ultrasound of the hepatobiliary system with elastography. Complex therapy regimen should include schisandrin for prevention of metabolic disorders in women with PCOS and overweight.

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Stanowisko Polskiego Towarzystwa Endokrynologicznego, Polskiego Towarzystwa Ginekologów i Położników oraz Polskiego Towarzystwa Endokrynologii Ginekologicznej w sprawie diagnostyki i leczenia zespołu policystycznych jajników

Cited by 18 publications

References 52 publications

Risk Factors of Overweight and Obesity Related to Diet and Disordered Eating Attitudes in Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Risk Factors of Overweight and Obesity Related to Diet and Disordered Eating Attitudes in Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

The value of the free androgen index depends on the phenotype of polycystic ovary syndrome — a single-centre experience

Polycystic ovary syndrome: approach to correction of metabolic disorders

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