Stanford Health Assessment Questionnaire Modified to Assess Disability in British Patients With Rheumatoid Arthritis

Kirwan, John R.; Reeback, J S

doi:10.1093/rheumatology/25.2.206

Cited by 457 publications

(254 citation statements)

References 6 publications

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“…VAS was represented by a 100 mm long line on which the patients evaluated their own health, with 100 mm representing the best health. RA patient functional status and disease activity were assessed by the Croatian translation of the Health Assessment Questionnaire (HAQ) [22] and by the DAS28-CRP [20] using a DAS calculator [23], respectively.…”

Section: Methodsmentioning

confidence: 99%

Is the prevalence of arterial hypertension in rheumatoid arthritis and osteoarthritis associated with disease?

et al. 2012

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Objective. In this study, we compare the prevalence of HT in RA and OA patients, exposed to high-and low-grade chronic inflammation, respectively , to assess the possible association between chronic inflammation and HT. Methods.A total of consecutive 627 RA and 352 OA patients were enrolled in this multicentric study. HT was defined as a systolic blood pressure (BP) ≥140 and/or diastolic BP ≥90 mmHg or current use of any antihypertensive drug. Overweight/obesity was defined as body mass index (BMI) ≥25, and patients ≥65 years old were considered elderly.Results. The prevalence of HT was higher in the OA group than in the RA group [73.3% (95%CI 68.4, 77.7) and 59.5% (95%CI 55.6, 68.4) P<0.001 respectively]. When the results were adjusted for age and BMI the HT prevalence was similar in both groups [RA 59%(95%CI 55.1, 63.8) OA 60%(95%CI 58.4, 65.0)]. In both groups, the prevalence of HT was higher in the elderly and those who were overweight than in the younger patients and those with a BMI <25 .Overweight (BMI ≥25) and age ≥65 were independent predictors of HT in multivariate logistic regression model, which show no association of HT and the disease (RA or OA). Conclusion.The results indicated a robust association of age and BMI with HT prevalence in both RA and OA. The difference in HT prevalence between RA and OA is rather due to age and BMI then to features of the disease, putting into question specific association of HT with RA.

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Section: Methodsmentioning

confidence: 99%

Is the prevalence of arterial hypertension in rheumatoid arthritis and osteoarthritis associated with disease?

et al. 2012

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“…The Disease Activity Score in 28 joints (DAS28) (16) was calculated at baseline using the standard formula, based on the serum C-reactive protein level (end point immunoturbidimetric agglutination test, mg/liter). Disease outcome was measured using the British modification of the Stanford Health Assessment Questionnaire (HAQ) (17), at baseline and each followup assessment; the HAQ is scored between 0 and 3, with 3 indicating the greatest degree of functional disability. Followup assessments were carried out 1-3, 5, 7, 10, and 15 years after baseline.…”

Section: Methodsmentioning

confidence: 99%

The relationship between oral contraceptive use and functional outcome in women with recent‐onset inflammatory polyarthritis: Results from the Norfolk Arthritis Register

Camacho¹,

Farragher²,

Verstappen³

et al. 2011

Arthritis & Rheumatism

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Objective. Use of oral contraceptives (OCs) may prevent the development of rheumatoid arthritis, but the influence of OC use on disease outcome is unresolved. The purpose of this study was to examine functional outcome and OC use in women with inflammatory polyarthritis (IP).Methods. The Norfolk Arthritis Register (NOAR) is an inception cohort of patients with recent-onset IP. We studied patient-reported history of OC use in 663 women who were born after 1945 and who had not used OCs during followup. OC use during followup was additionally investigated in 265 women who were <50 years old and had not undergone menopause or hysterectomy during followup. All patients were recruited to the NOAR between 1990 and 2004. Functional ability was assessed using the Health Assessment Questionnaire (HAQ), with adjustment for age at symptom onset.Results. The median followup was 4.9 years. In the investigation analyzing OC use before symptom onset, patients who had used OCs before symptom onset had lower HAQ scores throughout followup than patients who had not taken OCs before symptom onset (difference in score at 5-year followup ؊0.35; 95% confidence interval [95% CI] ؊0.51, ؊0.19). Patients who were taking OCs at baseline had lower HAQ scores over time than women who were not taking OCs at baseline but had previously done so (mean difference ؊0.21; 95% CI ؊0.40, ؊0.02). In the investigation analyzing OC use during followup, OC use during followup was associated with lower HAQ scores over time than no OC use during followup (mean difference ؊0.06; 95% CI ؊0.16, 0.03); however, this was only significant for women with moderate or severe functional disability at the previous assessment (mean difference ؊0.23; 95% CI ؊0.40, ؊0.07). Further adjustment for potential confounders and exclusion of hormone replacement therapy users had little impact.Conclusion. OC use is generally associated with a beneficial functional outcome in IP, and use before and at symptom onset appeared to have the most consistent benefit.

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“…The modified Health Assessment Questionnaire (mHAQ) was used to assess functional disability [12]. The presence of nodulosis and a smoking history were also documented.…”

Section: Methodsmentioning

confidence: 99%

The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis

et al. 2010

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To establish the diagnostic utility of the anticyclic-citrullinated peptide antibody (aCCP) test in Black South Africans with early rheumatoid arthritis (RA). A cross-sectional study comparing the rheumatoid factor (RF) and aCCP status in RA patients and a control group consisting of healthy subjects, and patients with systemic lupus erythematosus (SLE) and scleroderma. The sensitivity, specificity, positive (PPV) and negative predictive values of the aCCP test alone were 82.5%, 84.9%, 87.6% and 79% versus 81.7%, 90.7%, 92.5% and 78% for RF alone. The best specificity (95.3) and PPV (95.8%) was observed when both aCCP and RF tests were positive. Patients with erosive disease had a significantly higher mean RF titre compared with those with non-erosive disease (p=0.007). There was a trend towards an association of smoking (OR=4.1, 95% CI=0.9-18.6) and functional disability (p=0.07) with RF-positive status. No similar clinical associations were observed with aCCP. Almost a third of SLE patients were aCCP positive. Despite the best specificity and PPV observed when both the aCCP and RF tests were positive, our findings suggest that testing for aCCP is only cost-effective in the RF-negative patient in whom there is a strong clinical suspicion of RA.

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Stanford Health Assessment Questionnaire Modified to Assess Disability in British Patients With Rheumatoid Arthritis

Cited by 457 publications

References 6 publications

Is the prevalence of arterial hypertension in rheumatoid arthritis and osteoarthritis associated with disease?

Is the prevalence of arterial hypertension in rheumatoid arthritis and osteoarthritis associated with disease?

The relationship between oral contraceptive use and functional outcome in women with recent‐onset inflammatory polyarthritis: Results from the Norfolk Arthritis Register

The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis

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