Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V., Mayorov A.Yu. 10th edition

Dedov, Ivan I.; Shestakova, Marina V.; Mayorov, Alexander Y.; Mokrysheva, Natalia; Vikulova, Olga K.; Galstyan, Gagik R.; Кураева, Тамара Леонидовна; Петеркова, В. А.; Smirnova, Olga Mikhailovna; Старостина, Е. Г.; Суркова, Елена Викторовна; Sukhareva, Olga Yur'evna; Tokmakova, Alla Y.; Шамхалова, Минара Шамхаловна; Jarek-Martynova, Ivona Renata; Artemova, Ekaterina V.; Бешлиева, Диана Джемаловна; Бондаренко, О. Н.; Волеводз, Н Н; Gomova, Irina S.; Grigoryan, O. R.; Dzhemilova, Zera N.; Esayan, Roza M.; Ибрагимова, Людмила Ибрагимовна; Kalashnikov, Viktor Y.; Кононенко, Ирина Владимировна; Лаптев, Д. Н.; Lipatov, Dmitriy Valentinovich; Mel'nikova, Olga Georgievna; Mikhina, Margarina S.; Michurova, Marina S.; Мотовилин, Олег Геннадьевич; Nikonova, Tatiana Vasil'evna; Роживанов, Р. В.; Sklyanik, Igor A.; Shestakova, Ekaterina A.

doi:10.14341/dm12802

Cited by 138 publications

(5 citation statements)

References 49 publications

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“…The study was an observational, single-center, one-stage comparative study. The diagnosis of T2DM was established according to the criteria of the modern classification of DM [9]. All patients underwent angiography using the angiographic complex Artis one and the Digitron-3NAC computing system (Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China).…”

Section: Methodsmentioning

confidence: 99%

Pilot study of the FoxP3+ T lymphocyte count and its relationship with the Gensini score in patients with coronary heart disease and type 2 diabetes mellitus from a South American cohort

Estévez Gómez,

Acevedo Peña,

Castillo Goyeneche

et al. 2023

Preprint

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INTRODUCTIONOne of the pathogenic links between type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) is low-intensity chronic inflammation, which is limited by FoxP3+ regulatory T cells.MATERIALS AND METHODSA comparative, observational, single-center, single-stage study was carried out. The severity of atherosclerosis was assessed by calculating the Gensini score based on selective coronary angiography. The absolute and relative content of CD4+CD25 high FoxP3+ and CD4+CD25 low FoxP3+ T cells in the blood was evaluated by flow cytometry.RESULTS57 patients with chronic ischemic heart disease were examined. Patients with a combination of CHF and T2DM are characterized by an increase in the relative and absolute content of FoxP3+CD25 lymphocytes in the peripheral blood and an increase in the intranuclear content of FoxP3 in them, which is more pronounced in patients with disease moderate. atherosclerosis (Gensini score 17 to 45 points).CONCLUSIONSThis was the first Latin American study that managed to show the relationship between an increase in the content of low FoxP3+CD25 lymphocytes in the peripheral blood with atherosclerosis in patients with a combination of coronary artery disease and DM2.

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Section: Methodsmentioning

confidence: 99%

Pilot study of the FoxP3+ T lymphocyte count and its relationship with the Gensini score in patients with coronary heart disease and type 2 diabetes mellitus from a South American cohort

Estévez Gómez,

Acevedo Peña,

Castillo Goyeneche

et al. 2023

Preprint

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“…Общая численность больных СД в Российской Федерации на 01.01.2022 г. составила 4 871 863, из них с СД 2 типа (СД2) — 92,3% (4,5 млн). Однако если учесть долю недиагностированного СД2 в России, которая в среднем оценивается в 54%, можно заключить, что реальное количество больных должно составлять не менее 10 млн человек (6,9% населения РФ) [ 5 ].…”

Section: обоснованиеunclassified

“…Необходимо подчеркнуть, что в группе 2 не представлялось возможным отделить ранее не диагностированный СД2 от новых случаев гипергликемии ввиду наблюдательного характера исследований АКТИВ и АКТИВ 2 и отсутствия данных по уровню гликированного гемоглобина у большинства пациентов. Гипергликемия диагностировалась при уровне глюкозы в плазме венозной крови ≥7,0 ммоль/л [ 5 ]. Важно отметить, что из субанализа были исключены несколько случаев СД 1 типа, а также лица, у которых в индивидуальные регистрационные карты не были занесены показатели гликемии, фиксируемые по принципу «если известно».…”

Section: материалы и методыunclassified

The impact of carbohydrate metabolism disorders on the early and long-term clinical outcomes of patients with COVID-19 according to the AKTIV and AKTIV 2 registries

Салухов

Arutyunov

Tarlovskaya

et al. 2023

Probl Endokrinol (Mosk)

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BACKGROUND: Numerous studies indicate a high incidence of various disorders of carbohydrate metabolism against the new coronavirus infection. These disorders aggravate the course of infection and increase mortality. Thereby, analysis of risk factors for unfavorable outcomes and assessment of the long-term consequences of COVID-19 in patients with impaired carbohydrate metabolism is of great importance.AIM: To investigate the association between carbohydrate metabolism disorders in COVID-19 patients and mortality, course of infection, long-term consequences, as well as to identify risk factors for an unfavorable disease course.MATERIALS AND METHODS: A retrospective analysis of data from the combined multicenter non-interventional real-world AKTIV and AKTIV 2 registries was performed. The sample included 9290 patients who had COVID-19 with varying severity from June 29, 2020, to November 29, 2020 (AKTIV) and from October 01, 2020, to March 30, 2021 (AKTIV 2). The patients were divided into 3 groups: Group 1 — patients with intact carbohydrate metabolism, n=6606; Group 2 — patients with newly diagnosed hyperglycemia (NDH), n=1073; Group 3 — patients with a history of type 2 diabetes mellitus (DM2), n=1611. The groups were assessed for clinical and laboratory parameters, comorbidities, mortality, carbohydrate metabolic status, and well-being during the infection and at 12 months.RESULTS: The prevalence of carbohydrate metabolism disorders (CMD) was 28,9%, with DM2 patients accounting for 17,3% and patients with newly diagnosed hyperglycemia (NDH) for 11,6%. The mortality rate of patients with hyperglycemia of any origin was 10.6%, which was significantly higher compared to patients without hyperglycemia (3,9%). The probability of lethal outcome increased 2,48-fold in the group of patients with DM2 and 2,04-fold in the group of patients with NDH. At the same time, the probability of a lethal outcome decreased 2,94-fold in patients without CMD. At 12 months, patients with CMD showed a significantly higher frequency and longer persistence of complaints. This trend was more pronounced in patients with DM2 than in those with NDH. Only 1,7% of patients from the NDH group had type 2 diabetes and were receiving oral hypoglycemic medications one year after the infection. A prognostic model was developed to determine the risk of lethal outcome. The model included such known predictors as concomitant ischemic heart disease, history of myocardial infarction or stroke, blood glucose level, and age.CONCLUSION: Carbohydrate metabolism disorders aggravate the course of COVID-19 and increase mortality. One year after infection, patients with DM2 and NDH were more likely to have symptoms typical for post-COVID syndrome, and NDH resolved in most cases after the infection.

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“…Диагноз сахарного диабета (CД) устанавливался при уровне HbA1c ≥6,5 % и глюкозы плазмы натощак ≥7,0 ммоль/л и/или глюкозы крови при поступлении ≥11,1 ммоль/л [ 10 ].…”

Section: критерии постановки диагнозаunclassified

Dynamics the parameters of mineral metabolism in hospitalized patients with COVID-19, the impact of etiotropic and pathogenetic therapy

Maganeva,

Bondarenko,

Miliutina

et al. 2023

Probl Endokrinol (Mosk)

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The high prevalence of COVID-19 requires the research progress on the disease pathogenesis. There is a lot of data confirming the association between mineral metabolism and the severity of COVID-19.AIM: To study the dynamics of mineral metabolism parameters in patients with a confirmed COVID-19 at the time of hospitalization and after discharge, including the impact of etiotropic and pathogenetic therapy on them.MATERIALS AND METHODS: A single-center study of 106 patients (aged ≥18 years) with clinically or laboratory confirmed diagnosis of COVID-19 was carried out at the Endocrinology Research Centre, Moscow. Baseline biochemical parameters, including serum calcium, phosphorus, albumin, 25(OH)D, parathyroid hormone (PTH), inflammatory markers, and instrumental assessment of COVID-19 severity were performed before specific immunotherapy, as well as on 3rd and 7th days of hospitalization and before discharge. Statistical analysis was performed with Statistica 13 software (StatSoft, USA).RESULTS: On the first day, hypocalcemia (low albumin-adjusted calcium level) was detected in 40.6% of cases, the prevalence of vitamin D deficiency/insufficiency amounted to 95.3% of cases. At the same time, secondary hyperparathyroidism was identified only in 14.2% of patients. A comparative analysis of mineral metabolism during hospitalization (between 1, 3, 7 days of hospitalization and before discharge) during baricitinib treatment revealed a statistically significant increase in albumin-adjusted calcium by the end of hospitalization (p<0.001, Friedman criterion, Bonferroni correction p0=0.01). A pairwise comparison of subgroups, depending on the therapy, revealed a statistically significantly lower level of albumin-adjusted calcium on 3rd day among patients on baricitinib monotherapy or combined with tocilizumab compared with a subgroup of patients undergoing etiotropic treatment (2.16 [2.13; 2.18] mmol/l vs 2.23 [2.19; 2.28] mmol/l, p=0.002, U-test, Bonferroni correction p0=0.012).CONCLUSION: Patients with severe coronavirus infection are characterized by a high prevalence of vitamin D deficiency and hypocalcemia. Associations between calcium and saturation as well as the severity of lung lesion characterizes hypocalcemia as an important predictor of severe course and poor outcome in COVID-19. Pathogenetic therapy with baricitinib, including in combination with tocilizumab, contributes to achieve normocalcemia, but further studies are required.

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Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V., Mayorov A.Yu. 10th edition

Cited by 138 publications

References 49 publications

Pilot study of the FoxP3+ T lymphocyte count and its relationship with the Gensini score in patients with coronary heart disease and type 2 diabetes mellitus from a South American cohort

Pilot study of the FoxP3+ T lymphocyte count and its relationship with the Gensini score in patients with coronary heart disease and type 2 diabetes mellitus from a South American cohort

The impact of carbohydrate metabolism disorders on the early and long-term clinical outcomes of patients with COVID-19 according to the AKTIV and AKTIV 2 registries

Dynamics the parameters of mineral metabolism in hospitalized patients with COVID-19, the impact of etiotropic and pathogenetic therapy

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