Standards in isothermal microcalorimetry (IUPAC Technical Report)

Wadsö, Ingemar; Goldberg, Robert N.

doi:10.1351/pac200173101625

Cited by 316 publications

(140 citation statements)

References 27 publications

(44 reference statements)

Supporting

Mentioning

119

Contrasting

Order By: Relevance

“…Detailed information about studied samples, their purity and water content is presented in Table 1. [72]. The detailed procedure of calorimetric measurements was published elsewhere [73,74].…”

Section: Methodsmentioning

confidence: 99%

Effect of halogen substitution on the enthalpies of solvation and hydrogen bonding of organic solutes in chlorobenzene and 1,2-dichlorobenzene derived using multi-parameter correlations

et al. 2015

View full text Add to dashboard Cite

Enthalpies of solution at infinite dilution at 298 K, ΔsolnH A/Solvent , have been measured by isothermal solution calorimetry for 43 and 72 organic solutes dissolved in chlorobenzene and 1,2-dichlorobenzene, respectively. The measured ΔsolnH A/Solvent data, along with published ΔsolnH A/Solvent values taken from the published literature for solutes dissolved in both chlorobenzene solvents, were converted to enthalpies of solvation, ΔsolvH A/Solvent , using standard thermodynamic equations. Abraham model correlations were developed from the experimental ΔsolvH A/Solvent data. The best derived correlations describe the experimental gas-to-chlorobenzene and gas-to-1,2-dichlorobenzene enthalpies of solvation to within standard deviations of 1.5 kJ mol -1 and 1.9 kJ mol -1 , respectively. Enthalpies of X-H…π (X -O, N, and C) hydrogen bond formation of proton donor solutes (alcohols, amines, chlorinated hydrocarbons and etc.) with chlorobenzene and 1,2-dichlorobenzene were calculated based on the Abraham solvation equation. Obtained values are in good agreement with the results determined using conventional methods.

show abstract

Section: Methodsmentioning

confidence: 99%

Effect of halogen substitution on the enthalpies of solvation and hydrogen bonding of organic solutes in chlorobenzene and 1,2-dichlorobenzene derived using multi-parameter correlations

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The calorimeter was verified on the basis of the standard enthalpy of solution of urea and KCl (Calorimetric standard US, NBS) in water at (298.15 ± 0.01) K [43,44] as was described in our recent publication [45]. The value of solution enthalpy in water obtained by us from seven measurements for urea was (15.31 ± 0.06) kJ mol -1 (literature data 15.31 [46], 15.28 [47] and 15.30 kJ mol -1 [48]) and for KCl was (17.55 ± 0.05) kJ mol -1 (literature data 17.58 kJ mol -1 [43,44]). …”

Section: Methodsmentioning

confidence: 99%

Effect of base–acid properties of the mixtures of water with methanol on the solution enthalpy of selected cyclic ethers in this mixture at 298.15 K

Jóźwiak

Warczakowska

2015

J Therm Anal Calorim

View full text Add to dashboard Cite

The enthalpies of solution of cyclic ethers: 1,4-dioxane, 12-crown-4 and 18-crown-6 in the mixture of water and methanol have been measured within the whole mole fraction range at T = 298.15 K. Based on the obtained data, the effect of base-acid properties of watermethanol mixtures on the solution enthalpy of cyclic ethers in these mixtures has been analyzed. The solution enthalpy of cyclic ethers depends on acid properties of watermethanol mixtures in the range of high and medium water contents in the mixture. Based on the analysis performed, it can be assumed that in the mixtures of high methanol contents, cyclic ether molecules are preferentially solvated by water molecules.

show abstract

“…The S25's nanowatt sensitivity corresponds therefore to a temperature noise of 44 μK in a 1 Hz bandwidth, qualifying this device as a heat-conduction isothermal nanocalorimeter. 19 …”

Section: Electrical Noise Characterizationmentioning

confidence: 99%

A Microfabricated Nanocalorimeter: Design, Characterization, and Chemical Calibration

Reiserer

Tellinghuisen

et al. 2008

Anal. Chem.

View full text Add to dashboard Cite

A microfabricated titration calorimeter having nW sensitivity is presented. The device is achieved by modifying a commercial, suspended-membrane, thin-film thermopile infrared sensor. Chemical reactions are studied by placing a 50.0 nL droplet of one reagent directly on the sensor and injecting nL droplets of a second reagent through a micropipette by means of a pressure-driven droplet injector with 1% reliability in volume delivery. External thermal noise is miminized by a two-layer thermal shielding system. Evaporation is prevented by positioning the micropipette through a tiny hole in a cover glass, sealed by a drop of oil. The device is calibrated using two acid-base reactions: H 2 SO 4 + HEPES buffer, and NaOH + HCl. The measured power sensitivity is 2.90(4) V/W, giving a detection limit of 22 nW. The 1/e time constant for a single injection is 1.1 s. The day-to-day power sensitivity is reproducible to ∼2%. A computational model of the sensor reproduces the power sensitivity within 10% and the time constant within 20%. For a 50 nL sample and 0.8 to 1.5 nL titrant injection volumes, the heat uncertainty of 44 nJ corresponds to a 3σ detection limit of 132 nJ, or the binding energy associated with 2.9 pM of IgG-protein A complex.Microcalorimetry is widely used to measure enthalpy changes in chemical reactions, biochemical processes, and phase transitions, with typical detection limits of μW or μJ. [1][2][3][4][5][6][7] In the last decade, micromachining techniques 8;9 have been used to produce calorimetric devices with greatly reduced sample volumes and detection capabilities in the nW range. [10][11][12][13] There is a growing realization that these advances could enlarge the role of calorimetry in drug discovery, 14 optimization of yeast metabolism 15 Experimental Section Implementation of the CalorimeterThe S25 silicon-based thermopile sensor (Dexter Research Center, Inc., Dexter, MI) is shown in Figure 1. It has a twenty-junction thermopile with a Seebeck coefficient of 24 μV/K per junction. The thermopile is assembled under a thin (∼1.5 μm) membrane of SiO 2 /Si 3 N 4 . The metal tracks are directly below the membrane, and the sensing junctions are clustered at the center. Surrounding the free-standing membrane (the square shown in Figure 1D) is the aluminum heat sink that is attached to the porcelain body of the S25. The 0.5 mm well is formed by the membrane/heat sink at the bottom and the porcelain body of the sensor surrounding it. This well is modified to serve as our reaction chamber.The voltage signal generated by the S25 sensor is detected using an amplifier with a gain of 10 5 , then recorded by a PCI-6024E data acquisition board (National Instruments) in a desktop computer. A LabVIEW interface is used to control the experiment and display the readings. Electrical Noise CharacterizationThe S25 has an intrinsic noise voltage of 19.4 nV/√Hz. We use a low-noise instrumentation amplifier and chopper-stabilized operational amplifier to minimize additional contributions to the intrinsic Johnso...

show abstract

Standards in isothermal microcalorimetry (IUPAC Technical Report)

Cited by 316 publications

References 27 publications

Effect of halogen substitution on the enthalpies of solvation and hydrogen bonding of organic solutes in chlorobenzene and 1,2-dichlorobenzene derived using multi-parameter correlations

Effect of halogen substitution on the enthalpies of solvation and hydrogen bonding of organic solutes in chlorobenzene and 1,2-dichlorobenzene derived using multi-parameter correlations

Effect of base–acid properties of the mixtures of water with methanol on the solution enthalpy of selected cyclic ethers in this mixture at 298.15 K

A Microfabricated Nanocalorimeter: Design, Characterization, and Chemical Calibration

Contact Info

Product

Resources

About