Standardizing the Diagnostic and Therapeutic Approach to Newly Diagnosed Children with ITP: Prospective Data from the ITP Consortium of North America (ICON) Quality Improvement Initiative

Elkus, Hannah; Grace, Rachael F.; Buissereth, Taylah; Bennett, Carolyn M.; Rifkin-Zenenberg, Stacey; Gunn, Elizabeth; Lebensburger, Jeffrey D.; Angulo, Pablo; Davini, Monica; Rankin, Alexander W.; Nakano, Taizo A.; Schultz, Corinna L.; Pinchinat, Ashley; Hillier, Kirsty; Badawy, Sherif M.

doi:10.1182/blood-2022-170067

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study of a cohort recently published by Elkus et al collected retrospective data from seven centers comprising 205 patients diagnosed with ITP. Most patients received initial drug therapy, including intravenous immunoglobulin (54%), corticosteroids (9%), and anti-D (3%), whereas 37% were only followed [ 38 ]. In the 6 months after diagnosis, 11% were readmitted to hospital for management of chronic ITP [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Predictor Factors for Chronicity in Immune Thrombocytopenic Purpura in Children

et al. 2023

View full text Add to dashboard Cite

(1) Background: Immune thrombocytopenia (ITP) is an acute autoimmune blood disorder that is the main cause of thrombocytopenia in children. It is characterized by a decrease in platelets below 100 × 109/L, and limited evolution with severe complications such as intracranial hemorrhage. The chronic form is defined by the persistence of thrombocytopenia more than 12 months after diagnosis. (2) Methods: We performed a retrospective study over a period of 10 years (1 January 2011–31 December 2020) at the Emergency Clinical Hospital for Children “Sf. Maria”, Iasi. The aim of the study was to describe the clinical characteristics and to determine the prognostic factors in immune thrombocytopenia in children. (3) Results: In this study we included 271 children with ITP, comprising 123 females (45.4%) and 148 males (54.6%). The remission rate was higher in males, being 68.9% compared to 56.1% in females. Children with ITP under 9 years of age had a higher remission rate. Children with a platelet count > 10 × 109/L at diagnosis had a higher likelihood-of-remission rate compared to patients who presented initial platelet count below this value. (4) Conclusions: The risk factors highly suggestive for chronicity are: age at diagnosis, female sex, and the number of platelets at the onset of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%