Standardizing IV Infusion Medication Concentrations to Reduce Variability in Medication Errors

Bullock, Janna; Jordan, Deovina N.; Gawlinski, Anna; Henneman, Elizabeth A.

doi:10.1016/j.ccell.2006.08.008

Cited by 26 publications

(24 citation statements)

References 14 publications

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“…a combination of any of the previous themes; n = 18). [100][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116][117] A detailed summary of each individual study included in the review is presented in Table 2.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

Interventions to reduce medication errors in neonatal care: a systematic review

Nguyen

Mosel

Grzeskowiak

2017

Therapeutic Advances in Drug Safety

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Background: Medication errors represent a significant but often preventable cause of morbidity and mortality in neonates. The objective of this systematic review was to determine the effectiveness of interventions to reduce neonatal medication errors. Methods: A systematic review was undertaken of all comparative and noncomparative studies published in any language, identified from searches of PubMed and EMBASE and referencelist checking. Eligible studies were those investigating the impact of any medication safety interventions aimed at reducing medication errors in neonates in the hospital setting. Results: A total of 102 studies were identified that met the inclusion criteria, including 86 comparative and 16 noncomparative studies. Medication safety interventions were classified into six themes: technology (n = 38; e.g. electronic prescribing), organizational (n = 16; e.g. guidelines, policies, and procedures), personnel (n = 13; e.g. staff education), pharmacy (n = 9; e.g. clinical pharmacy service), hazard and risk analysis (n = 8; e.g. error detection tools), and multifactorial (n = 18; e.g. any combination of previous interventions). Significant variability was evident across all included studies, with differences in intervention strategies, trial methods, types of medication errors evaluated, and how medication errors were identified and evaluated. Most studies demonstrated an appreciable risk of bias. The vast majority of studies (>90%) demonstrated a reduction in medication errors. A similar median reduction of 50-70% in medication errors was evident across studies included within each of the identified themes, but findings varied considerably from a 16% increase in medication errors to a 100% reduction in medication errors. Conclusion: While neonatal medication errors can be reduced through multiple interventions aimed at improving the medication use process, no single intervention appeared clearly superior. Further research is required to evaluate the relative cost-effectiveness of the various medication safety interventions to facilitate decisions regarding uptake and implementation into clinical practice.

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Section: Overview Of Included Studiesmentioning

confidence: 99%

Interventions to reduce medication errors in neonatal care: a systematic review

Nguyen

Mosel

Grzeskowiak

2017

Therapeutic Advances in Drug Safety

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“…It is well established that variation in infusion practice causes error . The rule‐of‐six was developed for urgent situations in an era where infusion pumps were unavailable or were manually programmed and prone to failure.…”

Section: Discussionmentioning

confidence: 99%

A national scoping survey of standard infusions in paediatric and neonatal intensive care units in the United Kingdom

Oskarsdottir

Harris

Sutherland

et al. 2018

Journal of Pharmacy and Pharmacology

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The majority of paediatric and neonatal units in the UK used traditional weight-based methods for IV infusions and only 40% of responding units had established SCI. This local implementation of SCI resulted in a wide variation of presentations and concentrations and thus there is no true 'standardisation'. Further research should be conducted on harmonising these SCI across neonatal and paediatric care to facilitate adoption across all units.

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“…Similarly significant reductions in catheter related bloodstream infections were demonstrated with the use of standardized equipment and procedures . Standardization of medication administration practices has been demonstrated to reduce errors and costs and to improve other efficiencies .…”

Section: Introductionmentioning

confidence: 99%