Standardizing In Vitro β-Lactam Antibiotic Allergy Testing with Synthetic IgE
Pedro Quintero-Campos,
Roberto Gozalbo-Rovira,
Jesús Rodríguez-Díaz
et al.
Abstract:The global prevalence of β-lactam allergy poses a major challenge in administering first-line antibiotics, such as penicillins, to a significant portion of the population. The lack of β-lactam IgE antibody pools with defined selectivity hampers the standardization and validation of in vitro assays for β-lactam allergy testing. To address this limitation, this study introduces a synthetic IgE specific to β-lactam antibiotics as a valuable tool for drug allergy research and diagnostic tests. Using phage display … Show more
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