Standardizing end points in perioperative trials: towards a core and extended outcome set

Abstract

AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation 2014; 130: 2215-45 12. collaborators C-t, Shakur H, Roberts I, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376: 23-32 13. Roberts I, Perel P, Prieto-Merino D, et al. Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial.

Impact of changing positively worded items to negatively worded items in the Swedish web‐version of the Quality of Recovery (SwQoR) questionnaire

“…These results form part of an ongoing process in the development and psychometric evaluation of SwQoR . This evaluation process is in line with what Myles et al proclaim in their work to provide consensus‐based guidelines for clinical outcomes used in perioperative research: “Standardized Endpoints for Perioperative Medicine.”…”

“…The sad fact is that not all instruments used in research and clinical practice have undergone sufficient psychometric evaluation . The results presented here are concerned with the internal consistency, reliability, and construct validity of the SwQoR when the items are changed from positively to negatively worded.…”

American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on measurement to maintain and improve quality of enhanced recovery pathways for elective colorectal surgery

“…Both initiatives will focus predominantly on clinical trials, rather than epidemiology or QI, but it is likely that their recommendations will be of relevance, at least in part, in other settings. Both these initiatives will cover the full range of outcome measures discussed above, and are using systematic reviews followed by Delphi consensus methods to select and define relevant measures (Myles et al 2016). …”

Postoperative behavior change in children: All sorted or a tangled mess of spaghetti?

“…In adult perioperative medicine, a significant amount of work has gone into developing a standardized set of perioperative outcomes. The Core Outcome Measures for Perioperative and Anesthetic Care (COMPAC) and Standardizing Endpoints in Perioperative Medicine (StEP) have used the expertise of patients, carers, nurses, doctors, and researchers to develop a set of outcome measures that will become the standard reporting instruments in clinical trials . Following on from this, the Pediatric Perioperative Outcomes Group plan a similar approach and so any new child behavior tool must fit within this framework.…”