Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: our experience on 1,592 patients

Divisi, Duilio; Barone, Mirko; Bertolaccini, Luca; Rocco, Gaetano; Solli, Piergiorgio; Crisci, Roberto

doi:10.21037/jtd.2017.06.124

Cited by 12 publications

(11 citation statements)

References 29 publications

(17 reference statements)

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“…However, no significant difference was found amongst the malignant histopathologic subtypes. Also, Divisi et al (12) found no significant correlation between histopathological findings and SUV max (p=0.586). Davidson et al (26) showed that SCC was more 18 F-FDG avid than adenocarcinoma.…”

Section: Discussionmentioning

confidence: 94%

“…However, 18 F-FDG avidity can also be observed in benign conditions such as inflammation, infection; or malignant diseases can be less avid secondary to volumetric effects such as nodule size, ROI placement, etc. (12,13,14,15,16,17,18,19). SUV max values of half of the bronchoalveolar carcinoma and carcinoid tumors which constitute 2% of all lung cancers, may cause false negative PET results (20).…”

Section: Discussionmentioning

confidence: 99%

“…The maximum SUV (SUV max ) >2.5 is accepted as a threshold value for malignant lesions, although there can be some variations in the literature (8,9,10,11). On the other hand, 18 F-FDG avidity can also be observed in benign conditions such as inflammation, infection; or malignant diseases can be less avid secondary to volumetric effects such as nodule size (12,13,14,15,16,17,18,19). Kim et al (20) has mentioned that, SUV max values of half of the bronchoalveolar carcinoma and carcinoid tumors, which constitute 2% of all lung cancers, cause false negative PET results.…”

Section: Introductionmentioning

confidence: 99%

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Solitary Pulmonary Nodule: Morphological Effects on Metabolic Activity Assessment

Erdoğan

Evrimler

Aydın

et al. 2019

Mirt

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Objectives:We aimed to evaluate the effects of morphological characteristics of the solitary pulmonary nodules (SPN) on metabolic activity assessment. To the best of our knowledge, this is the first study to compare the volumetric metabolic activity parameters according to the morphologic parameters of the nodules.Methods:In this retrospective study, 18F-FDG positron emission tomography and computed tomography scans performed between 2011 and 2018 were evaluated by a nuclear and diagnostic radiologist. One hundred thirteen patients with SPNs with biopsy-proven diagnosis were included. SPNs were classified as solid, partially solid (PS), and ground glass opacity (GGO).Results:SPN diameter, SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and density were significantly higher in the malignant group. SUVmax, MTV, TLG increased in direct proportion to the diameter. There was no a significant difference between GGO, PS, and solid nodules in terms of SUVmax values. MTV and TLG values increased in parallel with the density of the nodules, but this increase was only significant in the malignant group. There was a significant difference between SPNs <2 cm and SPNs ≥2 cm in terms of MTV, while there was no difference in terms of SUVmax. The cut-off value determined by the ROC curve was found to be 4.39 for SUVmax, 7.33 mL for MTV and 31.88 g for TLG. The cut-off values for SUVmax of solid and subsolid nodules were close to each other, but cut-off values for MTV and TLG were higher in solid nodules.Conclusion:SUVmax, MTV, and TLG are affected by diameter and attenuation. We suggest using different MTV and TLG cut-off values for solid and subsolid nodules, but we suggest using same SUVmax values. MTV can be a more reliable parameter than SUVmax in prediction of malignancy in smaller nodules.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Solitary Pulmonary Nodule: Morphological Effects on Metabolic Activity Assessment

Erdoğan

Evrimler

Aydın

et al. 2019

Mirt

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“…Even if surgery is performed at an early stage of the disease, there is still a 25–50% recurrence rate . Solitary pulmonary nodules (SPNs) are single, well‐defined lesions of a diameter of ≤ 3 cm that are completely surrounded by gas‐containing lung tissue, without pulmonary atelectasis, hilar enlargement, or pleural effusion . At present, SPNs are a focus of research, primarily related to imaging, biomarkers, and histopathology.…”

Section: Introductionmentioning

confidence: 99%

Circulating tumor cell levels and carcinoembryonic antigen: An improved diagnostic method for lung adenocarcinoma

Ding

Zhou

et al. 2018

Thoracic Cancer

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BackgroundThe aim of this study was to determine a correlation between benign and malignant lung solitary pulmonary nodules (SPN), and analyze the association between circulating tumor cell (CTC) levels and different subtypes of lung adenocarcinoma.MethodsA total of 200 patients (80 with SPNs and 120 diagnosed with lung cancer) were included in the study. The CTC levels were quantified by identifying the folate receptor on the surface of tumor cells; clinical tumor specific markers were detected by biochemical immunization. The content of peripheral blood CTCs in benign and malignant lung SPN patients was detected and the differences in preoperative CTC levels in different pathological subtypes were analyzed. Based on the collected data, receiver operating characteristic curves were calculated and the rate of lung cancer was predicted.ResultsThe peripheral blood CTC levels in patients with malignant lung SPNs were higher than in patients with benign SPNs. The maximum nodule diameter, carcinoembryonic antigen, and CTC levels were independent risk factors for malignant lung SPNs. The peripheral blood CTC levels in patients with stage III–IV lung adenocarcinoma were higher than in stage I–II patients. The peripheral blood CTC levels in patients with microinvasive and invasive adenocarcinoma were higher than in adenocarcinoma in situ patients. The CTC levels in the peripheral blood of patients with maximum tumor diameter > 2 cm were higher than in patients with tumors < 2 cm.ConclusionThe detection of CTCs can be used as a biomarker for screening SPNs and diagnosing early‐stage lung cancer. Using the combination of CTC levels and CEA significantly improves the efficacy of lung adenocarcinoma diagnosis.

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“…Divisi et al [12] reported that solitary pulmonary nodules (SPNs) are incidentally found from 0.09 to 7% on chest imaging studies. The etiology of SPNs is broad and includes both benign (such as caused by infection, inflammation, or hemorrhage) and malignant disease (such as lung cancer and pulmonary metastases).…”

Section: Role Of 18f-fdg Pet-ct In Detection Of Extrahepatic Metastasismentioning

confidence: 99%

Role of 18F-FDG PET-CT in initial staging of hepatocellular carcinoma and its impact on changing clinical decision

Abdelhalim

Houseni

Elsakhawy

et al. 2020

Egypt Liver Journal

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Background: Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide. Extrahepatic metastasis from HCC occurs in one third of patients with most common sites being the lungs, lymph nodes, bone, and adrenal glands. Various conventional imaging modalities like ultrasonography, computed tomography, magnetic resonance imaging, and bone scan are used in the diagnosis and staging of HCC. Recently, PET performed with fluoro-2-deoxy-D-glucose (FDG) has proved valuable in providing important tumor-related qualitative and quantitative metabolic information that is critical to the diagnosis and staging of the disease. This article aims to show the role of 18F-FDG PET-CT in the initial staging of HCC and its impact on changing clinical decision. Main text: We discussed the previous studies on the ability of 18F-FDG PET-CT to detect HCC, vascular invasion, regional and distant metastasis. We also studied the relation between the histopathologic grading of HCC and its detectability by 18F-FDG PET-CT. Conclusions: 18F-FDG PET-CT has proved valuable in HCC staging and has a great impact on the clinical decision for HCC treatment.

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Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: our experience on 1,592 patients

Cited by 12 publications

References 29 publications

Solitary Pulmonary Nodule: Morphological Effects on Metabolic Activity Assessment

Solitary Pulmonary Nodule: Morphological Effects on Metabolic Activity Assessment

Circulating tumor cell levels and carcinoembryonic antigen: An improved diagnostic method for lung adenocarcinoma

Role of 18F-FDG PET-CT in initial staging of hepatocellular carcinoma and its impact on changing clinical decision

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