Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study

Chen, Chang-Ming; Lin, Lizhu; Zhang, Enxin

doi:10.1007/s11655-014-1864-9

Cited by 16 publications

(16 citation statements)

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“…As Table 1 showed, among the top 10 CM zheng , five belonged to deficiency zheng and the others could be categorized as a combination of deficiency and sufficiency or sufficiency syndrome. These results are consistent with those of our previous study [ 16 ] and with other research on syndrome distribution among constipation patients [ 8 , 17 ], which indicated that almost half of patients, especially older individuals and postpartum women, had deficiency syndromes [ 18 , 19 ].…”

Section: Discussionsupporting

confidence: 93%

Chinese herbal medicine for constipation: zheng-based associations among herbs, formulae, proprietary medicines, and herb–drug interactions

Zhong

Zheng

et al. 2016

Chin Med

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BackgroundAs current symptomatic treatments of constipation are still unsatisfactory, an increasing number of patients seek help from Chinese medicine (CM), particularly Chinese herbal medicine (CHM). This study aimed to review the most frequently used CHM herbs and formulae, proprietary CHMs, and herb–drug interactions for functional constipation using zheng (syndrome)-based differentiation, and to determine the current practice of zheng-based CHM treatments for functional constipation.MethodsWe developed a search strategy to include all the related clinical studies of CHM for constipation and set inclusion and exclusion criteria as studies on subjects with constipation of all ages and both sexes, using objective measures from laboratory or imaging techniques. The interventions included single herbs, CM classical formulae, CM new formulae, and Chinese herb-derived products and combination products. The clinical study types included were quasi- or randomized controlled trials, observational clinical studies, case series or case reports, and other types of appropriate research methods. The data concerning study design, sample size, mode of recruitment, sampling and diagnostic procedure, inclusion and exclusion criteria, and participants’ characteristics (including age, sex, and duration of constipation). CM patterns, CM treatment principles, treatment regimen, and CM treatment outcomes were recorded.ResultsA total of 29,832 relevant records were found, of which 8541 were duplicate records and 20,639 were excluded for reasons of irrelevance. The full text of 965 articles was retrieved for detailed assessment, following which 480 articles were excluded for various reasons. From the included articles, we retrieved 190 different CM zheng diagnoses from 485 individual studies. The most common zheng was dual deficiency of qi and blood (N = 48), which was diagnosed in 948 out of 15,740 subjects. The most frequently used classical formula was Ma-Zi-Ren-Wan (MZRW) (N = 75) and the most frequently used proprietary CHM was Run-Chang-Wan (N = 87). The most frequently used combined medication was Da Huang with sodium bicarbonate tablets (frequency across all studies, n = 23), followed by Fan Xie Ye with lactulose oral solution (n = 8), Ma-Ren-Ruan-Jiao-Nang with lactulose oral solution (n = 6) and Liu-Wei-An-Xiao-Jiao-Nang (n = 6) with mosapride citrate tablets.ConclusionThis study examined the use of CHM for constipation and summarized the herbs, formulae, proprietary medicines, and herb–drug interactions application. These data indicated there were limited information about herb-drug interactions and adverse effects of CHM and further randomized controlled trials with strict design are necessary.Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-016-0099-4) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Chinese herbal medicine for constipation: zheng-based associations among herbs, formulae, proprietary medicines, and herb–drug interactions

Zhong

Zheng

et al. 2016

Chin Med

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“…[16][17][18] Complementary and alternative medicine, such as TCM, is usually used as combined therapies in pain relief. 19,20 We first demonstrated the analgesic effect of HJBDO in a mouse model induced by acetic acid. In agreement with the outcome of clinical observation in our hospital, we found that administration of a clinically equivalent dose of HJBDO before the onset of acetic-acid induction significantly decreased the number of writhings, increased the inhibitory rate, and prolonged the latency time, which suggested that this formula was an effective and safe strategy for visceral pain.…”

Section: Discussionmentioning

confidence: 99%

Analgesic Effect of Chinese Herbal Formula Hua-Jian-Ba-Du Ointment on Visceral Pain in Mice Induced by Acetic Acid

Zhang

et al. 2015

Integr Cancer Ther

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“…Lizhu Lin, MD, of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, highlighted current issues with published clinical trials of CM for cancer. 37 - 41 In a search of ClinicalTrials.gov 42 and Chinese Clinical Trial Register, 43 42 registered trials with published results between 2008 and 2014 were identified. Most of these reports failed to properly document the CM diagnosis according to disease and syndrome differentiation.…”

Section: Meeting Proceedingsmentioning

confidence: 99%

“…Measures to ensure patient compliance and quality control of the study drug were inadequate. For clinical trials of CM on cancer in China, Lin indicated that the following are needed: integration of national resources of clinical research centers to build the capacity of multiagency cooperation and to use big data to explore the efficacy of CM on cancer, 41 identification of the most important clinical opportunities for the use of CM for treatment of common cancers, and selection of the most appropriate therapeutic outcome measures. Measures of quality of life may be particularly important in such trials.…”

Section: Meeting Proceedingsmentioning

confidence: 99%

Proceedings of the Strategy Meeting for the Development of an International Consortium for Chinese Medicine and Cancer

White

Lin

Lee

et al. 2017

JGO

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On November 3, 2014, in Bethesda, MD, the Office of Cancer Complementary and Alternative Medicine of the National Cancer Institute held a meeting to examine the potential utility and feasibility of establishing an international consortium for Chinese medicine and cancer. There is significant interest in the West in using components of Chinese medicine (CM) —such as botanicals and herbal medicines, acupuncture and acupressure, and qigong—in the field of oncology, as potential anticancer agents, for symptom management, and to improve quality of life. The proposal for a consortium on CM came from the Chinese Academy of Chinese Medical Sciences, with the aims of improving scientific communications and collaborations and modernizing the studies of CM for cancer. The US National Cancer Institute’s Office of Cancer Complementary and Alternative Medicine agreed to work with Chinese Academy of Chinese Medical Sciences to explore the feasibility of establishing an international consortium for Chinese medicine and cancer. At the meeting, participants from the United States, China, Canada, Australia, and Korea discussed issues in CM and cancer research, treatment, and management, including potential mechanisms of action, proof of efficacy, adverse effects, regulatory issues, and the need for improving the quality of randomized clinical trials of CM treatments and supportive care interventions. Presented in these proceedings are some of the main issues and opportunities discussed by workshop participants.

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Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study

Abstract: CM decoction could effectively treat opioid-induced constipation and improve patients' QOL at the same time. It is safe and doesn't affect the analgesic effect of opioids when treating constipation.

Cited by 16 publications

References 13 publications

Chinese herbal medicine for constipation: zheng-based associations among herbs, formulae, proprietary medicines, and herb–drug interactions

Chinese herbal medicine for constipation: zheng-based associations among herbs, formulae, proprietary medicines, and herb–drug interactions

Analgesic Effect of Chinese Herbal Formula Hua-Jian-Ba-Du Ointment on Visceral Pain in Mice Induced by Acetic Acid

Proceedings of the Strategy Meeting for the Development of an International Consortium for Chinese Medicine and Cancer

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