Standardized radiographic interpretation of thoracic tuberculosis in children

Concepcion, Nathan David P.; Laya, Bernard F.; Andronikou, Savvas; Daltro, Pedro; Sanchez, Marion O.; Uy, Jacqueline Austine U.; Lim, Timothy Reynold U.

doi:10.1007/s00247-017-3868-z

Cited by 47 publications

(74 citation statements)

References 42 publications

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“…In this study, children with unconfirmed TB and abnormal X-rays had differences in their metabolic fingerprint compared with those with normal X-rays. The differences in the metabolic fingerprint are consistent with studies interpreting the occurrence of radiological features from the pathway of incipient TB infection to subclinical and symptomatic TB 40 , 41 .…”

Section: Discussionsupporting

confidence: 85%

Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children

Comella-del-Barrio

Izquierdo-García

Gautier³

et al. 2021

Sci Rep

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Tuberculosis (TB) is a major cause of morbidity and mortality in children, and early diagnosis and treatment are crucial to reduce long-term morbidity and mortality. In this study, we explore whether urine nuclear magnetic resonance (NMR)-based metabolomics could be used to identify differences in the metabolic response of children with different diagnostic certainty of TB. We included 62 children with signs and symptoms of TB and 55 apparently healthy children. Six of the children with presumptive TB had bacteriologically confirmed TB, 52 children with unconfirmed TB, and 4 children with unlikely TB. Urine metabolic fingerprints were identified using high- and low-field proton NMR platforms and assessed with pattern recognition techniques such as principal components analysis and partial least squares discriminant analysis. We observed differences in the metabolic fingerprint of children with bacteriologically confirmed and unconfirmed TB compared to children with unlikely TB (p = 0.041 and p = 0.013, respectively). Moreover, children with unconfirmed TB with X-rays compatible with TB showed differences in the metabolic fingerprint compared to children with non-pathological X-rays (p = 0.009). Differences in the metabolic fingerprint in children with different diagnostic certainty of TB could contribute to a more accurate characterisation of TB in the paediatric population. The use of metabolomics could be useful to improve the prediction of TB progression and diagnosis in children.

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Section: Discussionsupporting

confidence: 85%

Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children

Comella-del-Barrio

Izquierdo-García

Gautier³

et al. 2021

Sci Rep

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“…13 This type of lesion can occur in young children because of their immature immune system. 20 Pleural effusion with bacteriological confirmation has been found in only a small percentage which is similar to the study in Mozambique. 5 This is mostly due to a delayed-type hypersensitivity reaction to MTB antigens that leak into the pleural space from the subpleural primary focus.…”

Section: Discussionsupporting

confidence: 84%

Radiological Findings of Pulmonary Tuberculosis in Children at Dr. Hasan Sadikin General Hospital Bandung 2018–2019

Ghaesani

Effendy

Wulandari

2021

amj

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Background: Tuberculosis (TB) remains a major cause of death worldwide, especially in children. Indonesia is ranked second as the largest contributor to TB. Chest X-rays have been used to diagnose pulmonary TB in children, however, the results are varied. Therefore, this study was performed to explore the radiological findings among children with pulmonary TB. Methods: Retrospective descriptive study was conducted by analyzing the chest X-ray findings retrieved from the medical records of all pulmonary TB children treated at Dr. Hasan Sadikin General Hospital during 2018 to 2019. Inclusion criteria were medical records of patients aged 1 month to 18 years diagnosed with pulmonary TB who underwent chest X-ray (n=223). Results: The highest incidence of pulmonary TB was found in the group of 10-18 years (43.9%) and female (50.2%). The results of chest X-ray were infiltrates (65.0%), lymphadenopathy (11.7%), cavity (7.6%), calcifications (7.6%), miliary (4.9%), pleural effusion (3.1%) and atelectasis (1.8%). Conclusion:Infiltrates are the major finding on Chest X-ray in children with TB.

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“…The pulmonary tuberculosis (TB) seen in pediatric patients is most often primary TB, whereas postprimary TB affects adults (64). Patients present with nonspecific symptoms such as cough, weight loss, fever, and lethargy.…”

Section: Tuberculosismentioning

confidence: 99%

“…At imaging, primary TB often appears as a segmental or lobar consolidation (65), often in the upper lobes. However, any lobe can be affected, particularly in children (64). Paratracheal adenopathy is seen if the upper lobes are involved, and perihilar adenopathy is seen if other lobes are involved.…”

Section: Tuberculosismentioning

confidence: 99%

Mediastinal Masses in Children: Radiologic-Pathologic Correlation

Biko¹,

Lichtenberger²,

Rapp³

et al. 2021

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Most pediatric masses in the chest are located in the mediastinum. These masses are often initially detected incidentally on chest radiographs in asymptomatic children, although some patients may present with respiratory symptoms. At chest radiography, the mediastinum has been anatomically divided into anterior, middle, and posterior compartments. However, with the International Thymic Malignancy Interest Group classification scheme, which is based on cross-sectional imaging findings, the mediastinum is divided into prevascular, visceral, and paravertebral compartments. In the prevascular compartment, tumors of thymic origin, lymphomas, germ cell tumors, and vascular tumors are encountered. In the visceral compartment, lymphadenopathy and masses related to the foregut are seen. In the paravertebral compartment, neurogenic tumors are most common. Using the anatomic location in combination with knowledge of the imaging and pathologic features of pediatric mediastinal masses aids in accurate diagnosis of these masses to guide treatment and management decisions.

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Standardized radiographic interpretation of thoracic tuberculosis in children

Cited by 47 publications

References 42 publications

Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children

Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children

Radiological Findings of Pulmonary Tuberculosis in Children at Dr. Hasan Sadikin General Hospital Bandung 2018–2019

Mediastinal Masses in Children: Radiologic-Pathologic Correlation

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