Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells

Park, Soo-yeon; Jin, Bora; Shin, Jae Ho; Kwon, Oran

doi:10.1016/j.biopha.2017.05.080

Cited by 12 publications

(5 citation statements)

References 28 publications

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“…ORV weakly stimulated insulin secretion in MIN 6 (mouse insulinoma 6) cells under H 2 O 2 -induced oxidative stress [ 226 ]. In insulin-resistant C57BLKS/J db/db mice fed with a high-fat diet, oral ORV suppressed the fasting blood glucose level, elevated the levels of insulin and C-peptide, and improved pancreatic β-cell dysfunction [ 227 ]. ORV stimulated insulin secretion in INS-1 cells and showed an anti-glycation potential through the inhibition of advanced glycation end-product formation [ 227 ].…”

Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Likhitwitayawuid

2021

Molecules

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Oxyresveratrol has recently attracted much research attention due to its simple chemical structure and diverse therapeutic potentials. Previous reviews describe the chemistry and biological activities of this phytoalexin, but additional coverage and greater accessibility are still needed. The current review provides a more comprehensive summary, covering research from 1955 to the present year. Oxyresveratrol occurs in both gymnosperms and angiosperms. However, it has never been reported in plants in the subclass Sympetalae, and this point might be of both chemotaxonomic and biosynthetic importance. Oxyresveratrol can be easily obtained from plant materials by conventional methods, and several systems for both qualitative and quantitative analysis of oxyresveratrol contents in plant materials and plant products are available. Oxyresveratrol possesses diverse biological and pharmacological activities such as the inhibition of tyrosinase and melanogenesis, antioxidant and anti-inflammatory activities, and protective effects against neurological disorders and digestive ailments. However, the unfavorable pharmacokinetic properties of oxyresveratrol, including low water solubility and poor oral availability and stability, have posed challenges to its development as a useful therapeutic agent. Recently, several delivery systems have emerged, with promising outcomes that may improve chances for the clinical study of oxyresveratrol.

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Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Likhitwitayawuid

2021

Molecules

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“…Morus alba branches are used in traditional Chinese medicine (TCM) and health beverages, and display antioxidant, anti-inflammatory, anti-hyperlipidemia, and anti-diabetic effects [ 20 ]. Additionally, Morus alba branches have been shown to improve insulin secretion and insulin sensitivity in C57BLKS/J db/db mice [ 21 ]. Several studies of Morus alba branches have been performed in vivo using extracts, and the compounds isolated from branches have been studied less frequently than those from other parts of the plant (root bark, leaf, and fruit).…”

Section: Introductionmentioning

confidence: 99%

Inhibition Mechanism of Components Isolated from Morus alba Branches on Diabetes and Diabetic Complications via Experimental and Molecular Docking Analyses

et al. 2022

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Previously, we reported the anti-diabetic effect of Morus alba root bark and the compounds therein. In our continuous study of other parts of this plant, the ability of the branch of Morus alba to inhibit α-glucosidase, protein tyrosine phosphatase 1B (PTP1B), and advanced glycation end products (AGEs) formation was evaluated. Moreover, there are no previous studies that have performed enzyme kinetics and molecular docking analyses, along with assessments of peroxynitrite (ONOO−) inhibitory activities. Since the Morus alba branch exhibited favorable inhibitory effects, repeated column chromatography was performed to obtain eight compounds, including four flavonoids (1, 3, 6, 8), one arylbenzofuran (2), one stilbene (5), one Diels–Alder-type adduct (7), and one sterol (4). Among them, compounds 1–3 and 5–7 were mixed-type inhibitors of α-glucosidase, sharing the same catalytic residues with acarbose and the same allosteric sites with (Z)-3-bytylidenephthalide. On the other hand, kuwanon C (1) and oxyresveratrol (5) interacted with residues of the allosteric site (α3 and α6 helices) of PTP1B, indicating their use as non-competitive inhibitors. Interestingly, kuwanon G (7) directly bound the catalytic site, or interrupted the binding between the substrate and the active site, as a mixed-type inhibitor. Moreover, most of the compounds exhibited greater activity against AGE formation and ONOO− than positive controls. The IC50 values required to inhibit ONOO− using compounds 1, 3, 5, 6, and 7 were reported for the first time, and range from 1.08 to 12.92 μM. Based on the structure–activity relationship, the presence of hydroxyl, resorcinol, and prenyl moieties was important in the prevention of diabetes’ pathological mechanisms, and these findings have been further supported by molecular docking analysis. These computational and experimental results will be useful in the development of therapeutic candidates to prevent/treat diabetes and its complications.

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“…Oxyresveratrol can increase plasma insulin level in vivo and stimulate insulin secretion in a pancreatic cell line. 67 Study results attributed the above benefits to the anti-oxidative and anti-inflammatory properties of these stilbenes and the underlying mechanisms will be discussed in the following sections.…”

Section: Food and Function Reviewmentioning

confidence: 99%

“…63 Administration of oxyresveratrol also improved pancreatic inflammation and insulin secretion. 67 Although currently there is no comparative study for antiinflammatory effects between resveratrol and its analogues in islet cells, related data are available from an experiment that applies microglial neurological cells, in which excessive NO was also proposed to mediate macrophage-dependent inflammation. In this study, pterostilbene demonstrated the strongest ability to reduce the level of LPS-induced proinflammatory cytokine secretion, followed by THSG, oxyresveratrol and resveratrol.…”

Section: Reviewmentioning

confidence: 99%

Hypoglycemic effects and associated mechanisms of resveratrol and related stilbenes in diet

Peng,

Lu,

Luo

et al. 2024

Food Funct.

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Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells

Cited by 12 publications

References 28 publications

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Inhibition Mechanism of Components Isolated from Morus alba Branches on Diabetes and Diabetic Complications via Experimental and Molecular Docking Analyses

Hypoglycemic effects and associated mechanisms of resveratrol and related stilbenes in diet

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