Standardized Delineation of Endocardial Boundaries in Three-Dimensional Left Ventricular Echocardiograms

Papachristidis, Alexandros; Galli, Elena; Geleijnse, Marcel L.; Heyde, Brecht; Alessandrini, Martino; Barbosa, Daniel; Papitsas, Michael; Pagnano, Gianpiero; Θεοδωρόπουλος, Κωνσταντίνος; Zidros, Spyridon; Donal, Erwan; Monaghan, Mark; Bernard, Olivier; D'hooge, Jan; Bosch, Johan G.

doi:10.1016/j.echo.2017.06.027

Cited by 10 publications

(10 citation statements)

References 22 publications

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“…A 16-segment model was used and LV segments were scored as 0 if non-visible and 1 if visible (6). LV endocardial borders at ED were automatically tracked and manual adjustments were performed when needed (12,13). LV volumes, including LVEF and systolic dyssynchrony index (SDI), global longitudinal strain (GLS), and global circumferential strain (GCS); average peak segmental longitudinal, circumferential, radial, and principle tangential strains; and twist and rotational indices were calculated by the software.…”

Section: Discussionmentioning

confidence: 99%

Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study

Saikhan

Alobaida

Bhuva

et al. 2020

Front. Cardiovasc. Med.

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Background: People of South Asian and African Caribbean ethnicities living in UK have a high risk of cardiometabolic disease. Limited data exist regarding detailed cardiometabolic phenotyping in this population. Methods enabling this are widely available, but the practical aspects of undertaking such studies in large and diverse samples are seldom reported. Methods: The Southall and Brent Revisited (SABRE) study is the UK's largest tri-ethnic longitudinal cohort. Over 1,400 surviving participants (58–85 years) attended the 2nd study visit (2008–2011); during which, comprehensive cardiovascular phenotyping, including 3D-echocardiography [3D-speckle-tracking (3D-STE)], computed tomography, coronary artery calcium scoring, pulse wave velocity, central blood pressure, carotid artery ultrasound, and retinal imaging, were performed. We describe the methods used with the aim of providing a guide to their feasibility and reproducibility in a large tri-ethnic population-based study of older people. Results: Conventional echocardiography and all vascular measurements showed high feasibility (>90% analyzable of clinic attendees), but 3D-echocardiography (3DE) and 3D-STE were less feasible (76% 3DE acquisition feasibility and 38% 3D-STE feasibility of clinic attendees). 3D-STE feasibility differed by ethnicity, being lowest in South Asian participants and highest in African Caribbean participants ( p < 0.0001). Similar trends were observed in men ( P < 0.0001) and women ( P = 0.005); however, in South Asians, there were more women with unreadable 3D-images compared to men (67 vs. 58%). Intra- and inter-observer variabilities were excellent for most of conventional and advanced echocardiographic measures. The test-retest reproducibility was good-excellent and fair-good for conventional and advanced echocardiographic measures, respectively, but lower than when re-reading the same images. All vascular measures demonstrated excellent or fair-good reproducibility. Conclusions: We describe the feasibility and reproducibility of detailed cardiovascular phenotyping in an ethnically diverse population. The data collected will lead to a better understanding of why people of South Asian and African Caribbean ancestry are at elevated risk of cardiometabolic diseases.

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Section: Discussionmentioning

confidence: 99%

Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study

Saikhan

Alobaida

Bhuva

et al. 2020

Front. Cardiovasc. Med.

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“…In the last years, there have been several initiatives to better assess the variability and reproducibility of strain measurements. Clinical, industrial and academic instances put a lot of efforts to discuss and better harmonize segmentation and tracking techniques (Amzulescu et al 2019;Papachristidis et al 2017;Voigt et al 2015). State-of-the-art algorithms were evaluated on synthetic echocardiographic images for which ground-truth myocardial delineation and deformation are known (Alessandrini et al 2016;De Craene et al 2013;D'hooge et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…However, its quantification from imaging data raises several concerns: validation of the software, standardization of the measurements, and interpretation of the results. Several efforts have been recently deployed to address the first two issues, in terms of definitions and computational aspects (Papachristidis et al 2017;Voigt et al 2015), and performance assessment (Alessandrini et al 2016;De Craene et al 2013;D'hooge et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Variability in the Assessment of Myocardial Strain Patterns: Implications for Adequate Interpretation

Duchateau

Lončarić

Čikeš

et al. 2020

Ultrasound in Medicine & Biology

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Variability in global and regional peak strain has been thoroughly studied, but not the variability in the spatiotemporal myocardial strain patterns. This study reports on such variability and its implications for adequate disease interpretation. Forty in-training operators were distributed on 20 workstations, and analyzed six cases with representative deformation patterns with commercial speckle-tracking. Inter-operator differences were quantified through the variability in myocardial delineations, spatiotemporal longitudinal strain patterns, and peak longitudinal strain. Intra-operator differences were assessed similarly using 10 repeated measurements from a single clinician expert. Delineations varied mainly along the lateral wall and at the valve level. Peak longitudinal strain variability was low to moderate. The spatiotemporal strain patterns were consistent despite high variability at the apex and near the valve. The results indicate that relevant pattern assessment is possible despite heterogeneous experience with speckle-tracking, and that careful interpretation of pattern abnormalities should be recommended before a more systematic quantitative analysis.

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“…The identity of non-visible segments were recorded in a spreadsheet during analysis as some regions are known to be less feasible, such as the apex, anterior and anterolateral segments (12). A 16-segment model was used and LV segments were scored as 0 if non-visible and 1 if visible (6).…”

Section: Methodsmentioning

confidence: 99%

Imaging protocol, feasibility and reproducibility of cardiovascular phenotyping in a large tri-ethnic population-based study of older people: the Southall and Brent Revisited (SABRE) study

Saikhan

Alobaida

Bhuva

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: People of South Asian and African Caribbean ethnicities living in UK have a high risk of cardiometabolic disease. Limited data exist regarding detailed cardiometabolic phenotyping in this population. Methods enabling this are widely available, but the practical aspects of undertaking such studies in large and diverse samples are seldom reported. Methods: The Southall and Brent Revisited (SABRE) study is the UK largest tri-ethnic longitudinal cohort. Over 1400 surviving participants (58-85 y) attended the 2nd study-visit (2008-2011) during which comprehensive cardiovascular phenotyping, including 3D-echocardiography (3D-speckle-tracking (3D-STE)), computed tomography, coronary artery calcium scoring, pulse-wave velocity, central blood pressure, carotid artery ultrasound and retinal imaging were performed. We describe the methods used with the aim of providing a guide to their feasibility and reproducibility in a large tri-ethnic population-based study of older people. Results: Conventional echocardiography and all vascular measurements showed high feasibility (>90% analyzable of clinic-attendees). 3DE and 3D-STE were less feasible in this age group (76% 3DE acquisition feasibility and 38% 3D-STE feasibility of clinic-attendees). Intra- and inter-observer variabilities were excellent for most of conventional and advanced echocardiographic measures. The test-retest reproducibility was good-excellent and fair-good for conventional and advanced echocardiographic measures, respectively, but lower than when re-reading the same images. All vascular measures demonstrated excellent or fair-good reproducibility. Conclusions: Detailed cardiovascular phenotyping is feasible and reproducible in an ethnically diverse population. The data collected will lead to a better understanding of why people of South Asian and African Caribbean ancestry are at elevated risk of cardiometabolic diseases.

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Standardized Delineation of Endocardial Boundaries in Three-Dimensional Left Ventricular Echocardiograms

Abstract: Comparing 3D LV tracings, the endocardial areas that are the most difficult to delineate were identified. The suggested protocol for LV tracing resulted in very good agreement among operators. The reference 3D meshes are available for online testing and ranking of LV tracing algorithms.

Cited by 10 publications

References 22 publications

Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study

Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study

Variability in the Assessment of Myocardial Strain Patterns: Implications for Adequate Interpretation

Imaging protocol, feasibility and reproducibility of cardiovascular phenotyping in a large tri-ethnic population-based study of older people: the Southall and Brent Revisited (SABRE) study

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