A 5-day old male infant, born at 38 1 6/7 weeks' gestation, presented to his pediatrician for a jaundice check. He was born via uncomplicated vaginal delivery to a mother with blood type A Rh1, who had a negative antibody screen result, as well as negative group B Streptococcus, Neisseria gonorrhoeae, and Chlamydia trachomatis screening results. He had an unremarkable birth hospitalization. His initial transcutaneous bilirubin at 40 hours and follow-up total serum bilirubin (TSB) at 51 hours, were both in the high intermediate risk zone on the Bhutani hyperbilirubinemia nomogram. 1 Given the lack of hyperbilirubinemia risk factors, he was discharged at 58 hours. A follow-up TSB at 111 hours was 18.5 mg/dL but below the phototherapy threshold of 20.7 mg/dL for a lower-risk infant. Because he was now in the high-risk zone and crossing risk isobars, a TSB was repeated the following day and was 19.8 mg/dL at 129 hours, remaining below the phototherapy threshold of 21 mg/dL. The infant was exclusively breastfeeding and had initially lost 3.4% of his birth weight but had gained 59 g since discharge. At this time, the family, primary pediatrician, and pediatric hospitalist decided to admit for phototherapy. On admission, he was a well-appearing, uncircumcised boy, with a benign examination except for mild, nonpurulent bilateral eye discharge without conjunctival injection or palpebral edema. He was afebrile, with normal vital signs for age. By report, his mother potentially had an early viral process. Per the admission note, because of his eye discharge, he underwent a complete blood count, C-reactive protein, chemistry, blood culture, and eye discharge culture; because of his mother' s possible viral process, he underwent an influenza and respiratory syncytial virus swab. His workup revealed a white blood cell (WBC) count of 11.5 K/mL (30% neutrophils, 51% lymphocytes, no bands); a C-reactive protein of 0.21 mg/dL (reference range 0.02-0.75 mg/dL); a direct bilirubin of 0.8 mg/dL (4% of TSB); blood type O Rh1; and negative results from viral swabs and eye culture. Additionally, the infant underwent a catheterized urinalysis and urine culture because of a concern for a relatively high direct bilirubin, potentially secondary to a urinary tract infection (UTI). His urinalysis results had trace blood, negative nitrites, negative leukocyte esterase, 5 to 10 WBC per high-power field (hpf), and negative bacteria. He was started on triple bank phototherapy and was not started on antibiotics. After 12 hours of phototherapy, the infant' s TSB decreased to 14.8 mg/dL. He received an additional 24 hours of phototherapy, after which his TSB was 10.2 mg/dL, and he was discharged. He breastfed well and gained ∼45 g/day during admission, had normal vital signs throughout, and had a benign discharge examination. The day after discharge, the urine culture grew .50 000 colony-forming units (CFUs)/mL of Staphylococcus epidermidis. The on-call pediatric hospitalist called the family back to the emergency department for a repeat sepsis work...