Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method

Efficacy and safety of monotherapy by pegvisomant, a growth hormone receptor antagonist, in Japanese patients with acromegaly

“…According to the revised reference intervals of serum IGF-I levels [6], the standard deviation (SD) score and are shown in Table 2. The serum IGF-I levels decreased over time until around Week 48 and the decreased level was maintained thereafter.…”

“…Meta-analysis had shown that normalization of IGF-I levels is crucially important to decrease the mortality in acromegaly [11]. The reference values of serum IGF-I level used in this study are currently the most accurate and practical data that are based on ageand gender-specific normative serum IGF-I range in Japanese [6], which is probably the most superb yardstick in the world. Therefore, assessment of the results in this study is presumed to be much reliable.…”

“…The clinical symptoms was evaluated with scores ranging from of children and those of adults were established independently, they might not properly reflect data during the transition period when serum IGF-I levels rapidly decline. Therefore, the revised normative range was published in 2012 [6].…”

Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly: a retrospective clinical study and review of the literature

“…Octreotideresistance was defined as serum GH levels of more than 1μg/L or serum IGF-I levels of more than 2 SD of age and sex matched reference subjects in a Japanese population [20], and no significant changes in GH or IGF-I levels for at least 6 months, irrespective of treatment with 20 mg or more-per month of octreotide LAR. The bromocriptine test was performed with a single oral 2.5 mg administration; and plasma GH levels were measured both before and 2-12 h after bromocriptine and nadir GH levels were recorded.…”

Low insulin resistance after surgery predicts poor GH suppression one year after complete resection for acromegaly: a retrospective study

“…beta, IGI, AUCinsulin, and plasma glucose levels (0 min, peak level, and 120 min) were compared between groups. When comparing IGF-1 levels between groups, each serum IGF-1 value was transformed into an age-and sex-adjusted standardized curve (IGF-1 [SD]) score, based on a report regarding reference intervals of serum IGF-1 values in a healthy Japanese population [26].…”