Standardized Analysis of Mandibular Osteoradionecrosis in a Rat Model

Tamplen, Matthew; Trapp, Kelley; Nishimura, Ichiro; Armin, Bob B.; Steinberg, Michael; Beumer, John; Abemayor, Elliot; Nabili, Vishad

doi:10.1177/0194599811400576

Cited by 35 publications

(44 citation statements)

References 25 publications

(61 reference statements)

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“…Thus, it is important study it and for this, use of experimental animal models is necessary (14,15). Earlier studies were done to develop an induction model of osteoradionecrosis in animals by causing changes in bone physiology with ionizing radiation (12,(14)(15)(16)(17)(18); however, none of these studies focused at preventing its occurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier studies were done to develop an induction model of osteoradionecrosis in animals by causing changes in bone physiology with ionizing radiation (12,(14)(15)(16)(17)(18); however, none of these studies focused at preventing its occurrence. In addition, although other studies evaluated the possible effects of radiation-protective agents on ionizing radiation damage(5-11), they tested the agents on acute complications and none correlated to delayed complications.…”

Section: Discussionmentioning

confidence: 99%

“…The region chosen for irradiation was the mandible, because it is more susceptible to osteoradionecrosis than the hind limbs in animals (15); thus, lower radiation doses had to be used because the head and neck region has more radiosensitive tissues and a high radiation dose could induce early mortality of the animals (17). With regard to the fractionate irradiation protocol, although it is recommended in head and neck radiotherapy, its execution is complex in experimental animal models as it requires multiple irradiations and repeated anesthesia, which is undesirable, because it makes reproducing the study more difficult and decreases the probability of the animal survival (4,14,16).…”

Section: Discussionmentioning

confidence: 99%

“…In order to simulate the situation in which a patient must have a tooth extracted sometime after radiotherapy, tooth extraction was performed on the animals, similar to others studies (14,18,20). However, unlike those studies, it was chosen to perform it 40 days after the animals received irradiation, a period sufficient to reveal histological changes in bone tissue in mandibles of irradiated rats (12), and because tooth extraction is contraindicated during treatment.…”

Section: Discussionmentioning

confidence: 99%

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Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

et al. 2017

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This study evaluated the action of ionizing radiation and the possible radioprotective effect of the non-steroidal anti-inflammatory drug meloxicam on the bone physiology of rat mandibles by assessing the alveolar socket healing and bone strength. Forty male Wistar rats were divided in 4 groups (n=10): control (CG), irradiated (IG), meloxicam (MG), meloxicam irradiated (MIG). A dose of 0.2 mg/kg meloxicam was administered to MG and MIG. After this, IG and MIG were irradiated with 15 Gy radiation dose in the mandible. Forty days after the above procedures, the mandibular first molars were extracted and the animals were killed after 15 or 30 days (n=5). Micro-computed tomography and bending test were used to evaluate alveolar socket healing and bone strength, respectively. At 15 days, bone volume, bone volume fraction and trabecular thickness were higher in the CG and MG than in the IG and MIG; and trabecular separation was higher in the IG compared with the others. At 30 days, there was a difference only in trabecular separation, which was higher in IG than in CG and MG, and MIG did not differ from the others. Bone strength was lower in IG compared with CG and MG, and MIG did not differ from the others. In conclusion, the ionizing radiation affected the bone physiology of rat mandibles, delaying the alveolar socket healing and reducing the bone strength. Moreover, the meloxicam had a positive effect on the trabecular separation in alveolar socket healing and on the bone strength.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

et al. 2017

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“…Moreover, it could focus on more details from specific issues as dose reduced fractionation protocols and modalities, as long as data obtained from in vitro studies [31][32][33][34][35][36][37][38][39][40].…”

Section: Cutting and Obtaining Blocks Of Dental Enamel And Root Dentinmentioning

confidence: 99%

ATR-FTIR Assessment of the Biochemical Composition and Micro Hardness of the Hard Tissues of Oral Cavity Submitted to Gamma Irradiation

Paredes¹,

Geraldo²,

Andrade³

2017

J Cancer Sci Ther

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Brachytherapy-Mediated Bone Damage in a Rat Model Investigating Maxillary Osteoradionecrosis

Armin

Nishimura²,

Tamplen³

et al. 2012

Arch Otolaryngol Head Neck Surg

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Similar to the mandible, the maxilla is susceptible to radiogenic bone injury as demonstrated by the significant decrease in bone volume of the radiated dental extraction socket. Despite radiologic similarities to mandibular ORN in the rat model, the maxilla demonstrated a more benign clinical course with a complete absence of bone exposure. Differences in the maxillary bone and microenvironment of the maxilla compared with the mandible may explain the subclinical response to radiation and lower incidence of maxillary ORN seen in patients. This maxillary model can be combined with our high-dose-rate mandibular ORN model to investigate these differences and better understand ORN.

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Standardized Analysis of Mandibular Osteoradionecrosis in a Rat Model

Cited by 35 publications

References 25 publications

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

ATR-FTIR Assessment of the Biochemical Composition and Micro Hardness of the Hard Tissues of Oral Cavity Submitted to Gamma Irradiation

Brachytherapy-Mediated Bone Damage in a Rat Model Investigating Maxillary Osteoradionecrosis

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