Standardization of Multiplex PCR for the Detection of PVCRT-O, Pvmdr1 Resistant Genes in Plasmodium Vivax and PFCRT-O Resistant Gene in Plasmodium Falciparum

Abstract

Malaria is considered as a neglected tropical disease because of the therapeutic failures and lack of immunoprophylactic methods. Plasmodium species develop resistant genes by selective drug pressure, detection of such resistant parasitic strains by various molecular methods is significant in improving treatment modalities. Pvcrt-o, Pvmdr1 in Plasmodium vivax and Pfcrt-o in Plasmodium falciparum are the genes responsible for antimalarial resistance. In this study