Standardization of MRI and Amyloid Imaging

Grothe, Michel J.; Kurth, Jens; Hampel, Harald; Krause, Bernd J.; Teipel, Stefan J.

doi:10.1016/b978-0-12-411464-7.00009-2

Cited by 2 publications

(1 citation statement)

References 129 publications

(201 reference statements)

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“…Lack of standardisation threatens to hamper the comparison and replication of results, increase analytical variability, and complicate the evaluation of methods [7]. Different methods of biomarker analyses give varying degrees of precision [19]. Drop outs or missing data are dealt with differently.…”

Section: Challenges In Comparing Data Setsmentioning

confidence: 99%

Challenges in Dementia Studies

Ong¹

2018

Alzheimer's Disease - The 21st Century Challenge

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Alzheimer's and other neurodegenerative diseases are generally incurable and often difficult to diagnose accurately. Yet early and accurate diagnosis of a neurodegenerative disease can potentially contribute to more effective treatment. Hence research efforts are moving towards early identification of high risk subjects and prevention of disease progression with biomarkers. Unfortunately dementia and biomarker studies are hampered by variables such as drop outs, challenges in comparing data sets, discordant biomarker sets, availability of histopathological confirmation at death, validity of cognitive testing, and nonlinear fluctuations in cognitive domains as disease pr o g r e s s e si nv i v oi ns u b j e c t s .T h i sc h a p t e ri s an assessment of the challenges in the early diagnosis of dementia, as well as a presentation of the issues faced in conducting dementia and biomarker studies.

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Section: Challenges In Comparing Data Setsmentioning

confidence: 99%

Challenges in Dementia Studies

Ong¹

2018

Alzheimer's Disease - The 21st Century Challenge

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Diffusion Tensor MR Imaging Evaluation in Children with Developmental Delay

Krishnarjun,

Rangankar,

Uz Zaman

2023

Medical Journal of Dr. D.Y. Patil Vidyapeeth

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Context: Developmental delay (DD) has a significant detrimental effect on the child’s quality of life. The critical time of diagnosis has a significant impact in preventing the decreased quality of life that the children with DD face, for which magnetic resonance imaging (MRI) with its new imaging techniques plays a pivotal role. Diffusion tensor imaging (DTI), a MRI technique, identifies microscopic features that are thought to be precursors to the ultimate stage of macroscopic tissue atrophy. Objectives: Spectrum of abnormal MRI brain findings was characterized, and role of DTI was evaluated in children with DD. Methods: Observational, descriptive study was performed on 80 children. Fifty cases of DD between the age of 1 month and 16 years, and 30 normal age-matched controls, underwent brain MRI with DTI for structural assessment of brain with measurement of fractional anisotropy (FA) of white matter tracts. “One sample t test” determined whether statistical significance existed between mean FA values of cases and controls. Results: Spectrum of hypoxic-ischemic insult and white matter abnormalities were the common findings seen in 21 (42%) and 19 (38%) children, respectively, amongst cases. On DTI, reduced FA was observed in white matter tracts of 24 (48%) children, most commonly in the corpus callosum of 13 (26%) children. Abnormal FA values in certain white matter tracts were observed in 6 (40%) out of 15 children with normal MRI brain. Conclusion: DTI exhibited the ability to pick up white matter tract abnormalities in the form of reduced FA values in children with DD, including some who showed structurally normal MRI.

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Standardization of MRI and Amyloid Imaging

Cited by 2 publications

References 129 publications

Challenges in Dementia Studies

Challenges in Dementia Studies

Diffusion Tensor MR Imaging Evaluation in Children with Developmental Delay

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