Standardization of method for the analysis of dextromethorphan in urine

Kim, Eun‐Mi; Lee, Juseon; Park, Mee-Jung; Choi, Sang-Kil; Lim, Mi Ae; Chung, Heesun

doi:10.1016/j.forsciint.2005.12.034

Cited by 17 publications

(7 citation statements)

References 1 publication

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“…26 In addition, the proposed extraction method used a small volume of organic solvent which is also less than those of other reports. 26,28,29 The total extraction time of our method was 35 min, which is longer than that required in liquid-liquid extraction (LLE) and headspace-solid phase microextraction (HS-SPME) as reported by Njuguna et al, 26 Nishikawa et al 30 and Rosenberger et al 33 However, an emulsion is obtained by the liquid-liquid extraction (LLE) method. The extraction time of the proposed SBSE method is faster than PDMS coated SBSE as reported by Crifasi et al 31 The extraction time of our method (35 min) was nonetheless sufficient to simultaneously extract all the analytes of interest.…”

Section: Comparison With Other Methodsmentioning

confidence: 78%

A stir bar sorptive extraction device coupled with a gas chromatography flame ionization detector for the determination of abused prescription drugs in lean cocktail samples

et al. 2022

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Section: Comparison With Other Methodsmentioning

confidence: 78%

A stir bar sorptive extraction device coupled with a gas chromatography flame ionization detector for the determination of abused prescription drugs in lean cocktail samples

et al. 2022

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“…In comparison, following a single 20 mg oral dose of dextromethorphan, healthy volunteers reached peak serum levels of 1.8 ng/mL in 2.5 hours (9); when 30mg of dextromethorphan was given orally four times a day for one week, peak plasma concentration averaged 2.4 ng/mL (range: 0.5-5.9 ng/mL) (9). On the other hand, Kim and Yoo reported that dextromethorphan abusers typically achieve serum levels of 5000 ng/mL (10,11).…”

Section: Discussionmentioning

confidence: 99%

Dextromethorphan-induced serotonin syndrome

Schwartz

Pizon

Brooks

2008

Clinical Toxicology

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Introduction. The ability of dextromethorphan to potentiate serotonin levels and lead to serotonin syndrome is well known but few case reports are published. The lack of published cases suggests therapeutic doses of these drugs are not enough to cause serotonin syndrome. We present two cases of serotonin syndrome associated with supra-therapeutic doses of dextromethorphan and therapeutic levels of a selective serotonin reuptake inhibitors (SSRI). Case Series. In case one, serum drug levels from admission revealed a dextromethorphan level of 950 ng/mL (normal<5), escitalopram of 23 ng/mL (normal<200), chlorpheniramine of 430 ng/mL (normal<20) and undetectable levels of aripiprazole and benztropine. In case two, serum drug levels from admission revealed a dextromethorphan level of 2820 ng/mL, sertraline of 12.5 ng/mL (normal<200), and caffeine of 1.4 μg/mL (normal≤ 9 μg/mL). Discussion. To our knowledge, these are the first cases to use serum levels of dextromethorphan and a SSRI to confirm dextromethorphan-induced serotonin syndrome. Conclusion. Our cases suggest supra-therapeutic dextromethorphan doses with a therapeutic amount of a SSRI are required for serotonin syndrome. More work is needed to answer this question more completely.

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“…A collaborative study was conducted to determine the prevalence of cannabinoids, opiates, cocaine metabolites, and amphetamines in blood samples from drivers killed in road accidents (488). Dextromethorphan and its metabolites were analyzed in urine using TLC and GC/MS (489). Quaternary ammonium drugs and herbicides in human whole blood were analyzed by LC/MS/MS with positive ESI following SPE (490).…”

Section: Drugs and Poisonsmentioning

confidence: 99%

Forensic Science

2007

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Short Tandem Repeats 4367 Single Nucleotide Polymorphisms 4367 Y-Chromosome and X-Chromosome Analysis 4368 Mitochondrial DNA Typing 4369 Nonhuman DNA Typing Systems and Microbial Forensics 4369 DNA Databases, Mass Screens, and Mass Disasters 4369 Interpretation and Statistical Weight of DNA Typing Results 4370 General Reviews 4370 Trace Evidence 4370 Petroleum Products and Explosives 4370 Hairs, Fibers, Glass, and Paint 4371 Gunshot Residue Analysis 4372 Fingerprints 4372 Miscellaneous Trace Evidence 4372 Drugs and Poisons 4373 Ethanol and Volatiles 4373 Cannabinoids 4373 Morphine and Related Narcotics 4373 Amphetamines 4374 Benzodiazepines 4375 γ-Hydroxybutyrate and Related Compounds 4375 Miscellaneous Drugs 4375 Other Techniques 4376 Literature Cited 4377This applications review aims to present a concise survey of articles appearing in publications that primarily appeal to forensic practitioners. With this objective, we have focused our attention on the following journals:

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Standardization of method for the analysis of dextromethorphan in urine

Cited by 17 publications

References 1 publication

A stir bar sorptive extraction device coupled with a gas chromatography flame ionization detector for the determination of abused prescription drugs in lean cocktail samples

A stir bar sorptive extraction device coupled with a gas chromatography flame ionization detector for the determination of abused prescription drugs in lean cocktail samples

Dextromethorphan-induced serotonin syndrome

Forensic Science

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