Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers

Russo, Sandra A.; Walker, Joan L.; Carlson, Jay W.; Carter, Jeanne; Ward, Leigh C.; Covens, Allan; Tanner, Edward J.; Armer, Jane M.; Ridner, Sheila H.; Hayes, Sandra C.; Taghian, Alphonse G.; Brunelle, Cheryl L.; Lopez-Acevedo, Micael; Davidson, Brittany; Schaverien, Mark V.; Ghamande, Sharad; Bernas, Michael; Cheville, Andrea L.; Yost, Kathleen J.; Schmitz, Kathryn H.; Coyle, Barbara; Zucker, Jeannette; Enserro, Danielle; Pugh, Stephanie L.; Paskett, Electra D.; Ford, Lea Berrang; McCaskill‐Stevens, Worta

doi:10.1016/j.ygyno.2020.10.026

Cited by 18 publications

(8 citation statements)

References 44 publications

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“…When analyses were restricted to obese women, incidence increased to 67% (BIS) and 54% (SRLS). Further prospective studies capturing quality of life and LEL in women with early-stage endometrial carcinoma are needed, as well as a standardization of measurements to refine and redefine the optimal risk-reduction strategies to diminish morbidity associated with treatment of gynecologic cancers [ 63 ].…”

Section: The Sentinel Lymph Node Conceptmentioning

confidence: 99%

Update on Sentinel Lymph Node Biopsy in Surgical Staging of Endometrial Carcinoma

Eriksson

Davidson

Trent

et al. 2021

JCM

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Sentinel lymph node (SLN) biopsy has emerged as an alternative staging approach in women with assumed early-stage endometrial carcinoma. Through image-guided surgery and pathologic ultrastaging, the SLN approach is introducing “precision medicine” to the surgical management of gynecologic cancers, providing a comprehensive evaluation of high-yield lymph nodes. This approach improves the surgeons’ ability to detect small-volume metastatic disease while reducing intraoperative and postoperative morbidity associated with lymphadenectomy. Although the majority of clinicians in Europe and the USA have recognized the value of SLN biopsy in endometrial carcinoma and introduced this as part of clinical practice, there is ongoing debate regarding its role in very low-risk patients as well as in patients at high risk of nodal metastasis. The significance of low-volume metastasis is not fully understood, and there is no consensus in regard to how the presence of isolated tumor cells should guide adjuvant therapy. Standardized protocols for histopathologic evaluation of SLNs are lacking. In this review article we aim to provide a framework for the introduction of SLN biopsy in endometrial cancer, give an updated overview of the existing literature, as well as discuss potential controversies and unanswered questions regarding this approach and future directions.

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Section: The Sentinel Lymph Node Conceptmentioning

confidence: 99%

Update on Sentinel Lymph Node Biopsy in Surgical Staging of Endometrial Carcinoma

Eriksson

Davidson

Trent

et al. 2021

JCM

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“…In a systematic review of the measurement properties of clinical instruments for measurement of lymphedema, Hidding et al highlighted the limitations associated with research of lymphedema: lack of a uniform definition of lymphedema and a gold standard as a reference test, and bias attributed to study design, patient selection, description of lymphedema, blinding of test outcomes, and the number of included participants [Hidding et al 2016]. Today, there is still no consensus on a gold standard for diagnosing or grading lymphedema [Lindqvist, et al 2017, Biglia et al 2017, Executive Committee of the International Society of Lymphology 2020, Russo et al 2021].…”

Section: Diagnostics Of Lymphedemamentioning

confidence: 99%

“…Consequently, it is difficult to compare the results and draw reliable conclusions. Still, there is no consensus on what method should be considered as the 'gold standard' to define lymphedema and for use in research or in clinical practice [Lindqvist et al 2017, Russo et al 2021.…”

Section: Introductionmentioning

confidence: 99%

On lymphedema of the lower limbs after treatment of endometrial cancer : with emphasis on incidence, quality of life, risk factors, and health economy

Wedin

2021

Linköping University Medical Dissertations

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“…Many survivors of gynaecological cancer live with discomfort, disfigurement, loss of activity, and reduced QoL due to lymphoedema. For certain patients, this morbidity is exacerbated by recurrent infections and hospitalisations, leading to deterioration and eventual disability [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Sentinel Lymph Node Impact on the Quality of Life of Patients with Endometrial Cancer

García-Pineda

Hernández

Garrido-Mallach

et al. 2023

JPM

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Objective: Given the improvement in the surgical treatment of endometrial cancer with the inclusion of sentinel lymph node biopsy (SLNB), our aim was to evaluate the impact of this minimally invasive and tailored nodal assessment on patients’ quality of life (QoL). Methods: This was a cross-sectional study conducted in a single-centre, tertiary-level hospital. Patients diagnosed with preoperative early-stage endometrial cancer, who underwent primary surgical treatment between August 2015 and November 2021, were included. The enrolled patients were divided into two cohorts according to the nodal staging performed: the first group underwent only SLNB (SLNB group); the second group underwent pelvic and/or para-aortic lymphadenectomy (LND group). We evaluated the overall QoL using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life core 30-item questionnaire (EORTC QLQ-C30) and a sexual health questionnaire (EORTC SHQ-C20). The scores were compared between the groups. Results: Ninety patients were enrolled in the study: 61 (67.8%) in the SLNB group and 29 (32.2%) in the LND group. In the LND group, 24 (82.7%) patients underwent pelvic and para-aortic LND, while 5 (17.3%) patients underwent pelvic LND. The assessment of the functional scales showed better results for the SLNB group than for the LND group, with a significantly lower impact on physical status (8.2% vs. 25%, respectively; p = 0.031). In terms of the symptom scales, the SLNB group reported a significantly lower negative impact on sleep quality (4.9% vs. 27.6%, respectively; p < 0.01), pain (1.6% vs. 13.8%, respectively; p = 0.019), and dyspnoea (0% vs. 10.3%, respectively; p = 0.011) than the LND group. The SLNB group had better results for all analysed items regarding sexual QoL. Conclusions: The implementation of a surgical technique with SLNB improved patients’ overall QoL by increasing their well-being in the functional and symptom spheres.

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Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers

Cited by 18 publications

References 44 publications

Update on Sentinel Lymph Node Biopsy in Surgical Staging of Endometrial Carcinoma

Update on Sentinel Lymph Node Biopsy in Surgical Staging of Endometrial Carcinoma

On lymphedema of the lower limbs after treatment of endometrial cancer : with emphasis on incidence, quality of life, risk factors, and health economy

Sentinel Lymph Node Impact on the Quality of Life of Patients with Endometrial Cancer

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