Standardization of bronchial inhalation challenge procedures

Chai, Hyman; Farr, Richard S.; Froehlich, Luz A.; Mathison, David A.; McLean, James A.; Rosenthal, Richard R.; Sheffer, Albert L.; Spector, Sheldon L.; Townley, Robert G.

doi:10.1016/0091-6749(75)90107-4

Cited by 1,369 publications

(509 citation statements)

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“…Methacholine bronchial provocation testing was carried out, using the modified method of Chai et al [10]. Concentrations of 1.25, 2.5, 6.25, 12.5, and 25 mg/mL of methacholine were prepared by dilution with buffered saline.…”

Section: Methacholine Bronchial Provocation Testsmentioning

confidence: 99%

Citrus red mite (Panonychus citri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers

Kim

Son

Kim

et al. 1999

Clin Experimental Allergy

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SummaryObjective To evaluate type I hypersensitivity to citrus red mite (Panonychus citri), its prevalence, and relationship to respiratory dysfunction, a cross-sectional survey was performed among citrus farmers on Cheju Island, Korea. Materials and methods Questionnaires, and skin prick test responses to 11 common inhalant allergens and citrus red mite were performed in 181 citrus farmers, and serumspecific IgE antibodies to citrus red mite were measured by ELISA in sera of 123 subjects. To determine airway hyperresponsiveness, methacholine bronchial provocation tests were performed in 55 subjects who complained of recurrent lower respiratory symptoms. Results The prevalence of asthma-based on presence of asthmatic symptoms on the questionnaire and airway hyperresponsiveness to methacholine, and allergic rhinitis based on presence of nasal symptoms on the questionnaire and positive skin-test response were 12.1% and 19.3%, respectively. The positive rate of skin responses to one or more of 11 common inhalant allergens excluding citrus red mite was 17.1%, and if citrus red mite was included, 25.9% of farmers had positive responses. On skin prick tests, citrus red mite (16.5%) was the most common sensitizing allergen, followed by cockroach (11.0%), Dermatophagoides pteronyssinus (9.9%), and D. farinae (9.3%). Among farmers with asthma and allergic rhinitis, the positive skin responses to citrus red mite were noted in 54.5 and 68.5%, respectively. Serum-specific IgE antibodies to citrus red mite were detected in 45 farmers (36.5%) of the 123 tested, and there was significant correlation between specific IgE level and weal (A/H ratio) to citrus red mite (r ¼ 0.57, P < 0.001). The prevalence of asthma was higher in subjects with positive skin responses or high serum-specific IgE antibodies to citrus red mite than in those without skin response or serum specific IgE (P < 0.05, respectively). Conclusion Citrus red mite is the most important allergen in citrus farmers with asthma and rhinitis in which causative allergen has not been identified. It should be included in the skin test battery for screening the causative allergen in farmers exposed to citrus red mite.

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Section: Methacholine Bronchial Provocation Testsmentioning

confidence: 99%

Citrus red mite (Panonychus citri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers

Kim

Son

Kim

et al. 1999

Clin Experimental Allergy

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“…Airway hyperreactivity to methacholine was determined by a method described previously. 11 An aerosol of 0.9% NaCl followed by serially doubled concentrations of methacholine (0.075 to 25 mg/mL) was inhaled until a decrease in FEV 1 of 20% or more was observed. From the decline in FEV 1 , the methacholine provocation concentration causing a 20% fall in FEV 1 (PC 20 ) was calculated.…”

Section: Spirometry and Measurement Of Airway Hyperreactivitymentioning

confidence: 99%

Seasonal Variation of Skin Reactivity and Specific IgE Antibody to House Dust Mite

Nahm

Park

Kang

et al. 1997

Annals of Allergy, Asthma & Immunology

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“…MBPT was carried out using the modi®ed method described by Chai et al [13]. Concentrations of 1.25, 2.5, 6.25, 12.5, and 25 mg/mL of methacholine were prepared by dilution with buffered saline.…”

Section: Methodsmentioning

confidence: 99%

Bronchial responsiveness to methacholine is increased in citrus red mite (Panonychus citri)‐sensitive children without asthmatic symptoms

Min

Park

Lee

et al. 2000

Clin Experimental Allergy

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SummaryBackground A recent investigation has suggested that citrus red mite (Panonychus citri, CRM) is a common sensitizing allergen among children living around citrus farms. Objective A cross-sectional survey was performed to evaluate the bronchial responsiveness to methacholine in CRM-sensitive children without asthmatic symptoms. Subjects and methods A total of 375 children living around citrus farms were enrolled in this study. There were 201 boys and 174 girls with a mean age of 12.5 (range 7±16) years. Each subject was evaluated by a questionnaire, a skin prick test with 13 common inhalant allergens including CRM, and a methacholine bronchial provocation test (MBPT). Results Positive rate of MBPT (PC 20 -methacholine < 25 mg/mL) was higher in atopic rhinitic and atopic control children than in nonatopic rhinitic and nonatopic control subjects (41.3% and 33.3% vs 17.2% and 15.4%, respectively, both P < 0.05). Slope of dose± response curve (DRS, %/mg/mL) was higher in atopic rhinitic children than in nonatopic rhinitic, atopic control and nonatopic control subjects (14.3 6 0.87 vs 9.4 6 0.72, 10.0 6 1.37 and 9.2 6 1.51, P < 0.05, respectively). Both the positive rate of MBPT and the DRS were increased in children with positive skin response to CRM than in those without sensitization (48.2% vs 22.9%, P 0.0001; 15.6 6 1.26 vs 10.2 6 0.65, P 0.0001). Conclusion Bronchial responsiveness is increased in citrus red mite-sensitive children even if they have no asthmatic symptoms.

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Standardization of bronchial inhalation challenge procedures

Cited by 1,369 publications

References 0 publications

Citrus red mite (Panonychus citri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers

Citrus red mite (Panonychus citri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers

Seasonal Variation of Skin Reactivity and Specific IgE Antibody to House Dust Mite

Bronchial responsiveness to methacholine is increased in citrus red mite (Panonychus citri)‐sensitive children without asthmatic symptoms

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