Standardisation of 64Cu using a software coincidence counting system

Havelka, Miroslav; Sochorová, Jana

doi:10.1016/j.apradiso.2013.11.107

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…Cu-64 activities were calculated by extrapolation of data acquired with a gate set over the 1346 keV gamma-ray peak, as has been described by others (Kawada, 1986; Wanke et al, 2010; Sahagia et al, 2012; Bé et al, 2012; Havelka and Sochorová, 2014). Data acquired on analog and digital (with off-line analysis) systems returned activities that consistently agreed to < 0.1 %.…”

Section: Resultsmentioning

confidence: 99%

Standardization of 64Cu activity

Bergeron

Cessna

Fitzgerald

et al. 2018

Applied Radiation and Isotopes

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The complex decay scheme that makes 64Cu promising as both an imaging and therapeutic agent in medicine also makes the absolute measurement of its activity challenging. The National Institute of Standards and Technology (NIST) has completed a primary activity standardization of a 64CuCl2 solution using the 4πβ(LS)-γ(NaI) live-timed anticoincidence (LTAC) counting method with a combined standard uncertainty of 0.51 %. Two liquid scintillation (LS) counting methods were employed for confirmatory measurements. Secondary measurements were made by high-purity germanium detectors, pressurized ionization chambers (IC), and a well-type NaI(Tl) counter. Agreement between the LTAC-based standard and standards from other laboratories was established via IC calibration factors. Poor agreement between methods and with theoretical IC responses may indicate a need for improved β+/− branching probabilities and a better treatment of β+/− spectra.

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Section: Resultsmentioning

confidence: 99%

Standardization of 64Cu activity

Bergeron

Cessna

Fitzgerald

et al. 2018

Applied Radiation and Isotopes

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“…The ratio of anti-coincident to total counts in each gate gave the inefficiency parameters Y 1 , Y 2 , and Y 3 , used for activity determinations. Previous standardizations of 64 Cu have followed Kawada (1986), plotting N LS vs. Y 3 and taking the activity ( N 0 ) to be the intercept ( N LS (0)) using a linear extrapolation (Wanke et al, 2010; Sahagia et al, 2012; Bé et al, 2012; Havelka and Sochorová, 2014), NLS=N0(1−Y3). Using this extrapolation without further correction ignores the difference in K/L/M electron capture ratios between the two electron capture branches, which is expected to cause a bias in the intercept (Funck and Nylandstedt Larsen, 1983). This approach also ignores any effect of the positron or beta branch inefficiencies being non-linear functions of Y 3 .…”

Section: Methodsmentioning

confidence: 99%

“…The National Institute of Standards and Technology (NIST) recently performed a primary standardization of 64 Cu activity (Bergeron et al, 2017). The standard was realized by live-timed anticoincidence (LTAC) counting, gating on the 1346 keV gamma peak as described by Kawada (1986) and others (Wanke et al, 2010; Sahagia et al, 2012; Bé et al, 2012; Havelka and Sochorová, 2014). The very small emission probability of the 1346 keV γ-ray (0.4748 %; Bé et al, 2011) requires longer-than-typical count times and makes the measurement somewhat difficult.…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo modelling of live-timed anticoincidence (LTAC) counting for Cu-64

Bergeron

Fitzgerald

2018

Applied Radiation and Isotopes

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The radionuclide copper-64 is a promising candidate for nuclear medicine, but its complex decay creates challenges in the primary standardization of its activity. Monte Carlo simulations of live-timed anticoincidence (LTAC) counting of Cu were used to calculate corrections to extrapolation intercepts, resulting in improved activity determinations. A small correction (-0.33%) to the linear extrapolation of LTAC data acquired with a γ-gate over the 1346keV gamma peak was determined. We discuss the physical origin of the correction. We also use experimental data to demonstrate a Monte Carlo scaling that allows for inclusion of data acquired with a γ-gate set over the annihilation photon peak(s).

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“…3) Determinação das probabilidades de emissão gama por decaimento destes radionuclídeos por meio de medidas absolutas e em espectrômetro de HPGe calibrado. (CHRISTMAS et al, 1983;KAWADA, 1986) como os mais recentes (QAIM, et al, 2007;WANKE et al;LUCA, et al, 2012;AMIOT, et al, 2012;SAHAGIA, et al, 2012;BÉ, et al, 2012;HAVELKA and SOCHOROVÁ , 2014;PIBIDA et al, 2017) (VOLKERT et al, 1991;NIJSEN et al, 2001;BREITZ et al, 2006;COSTA, 2008;LIBERAL, 2013;RANJBAR et al, 2015;ZOLGHADRI et al, 2015;TEHRANI, 2016 (OKUNO e YOSHIMURA, 2010;KRANE, 1988).…”

Section: Introductionunclassified

Padronização em sistema primário por coincidências 4πβ-γ e determinação das intensidades de emissão gama por decaimento dos radionuclídeos Cu-64 e Ho-166

Yamazaki¹

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AGRADECIMENTOSÀ Dra. Marina Fallone Koskinas, orientadora deste trabalho, um agradecimento muito especial, pelo seu apoio, atenção, parceria e disponibilidade constante, pela confiança em mim depositada e pelos conhecimentos transferidos durante o desenvolvimento desta tese. Ao Laboratório de Metrologia Nuclear (LMN), na pessoa do Dr. Mauro da Silva Dias, pelo valioso, essencial suporte técnico oferecido no decorrer deste trabalho. Aos colegas de operação do reator IEA-R1, nas irradiações efetuadas. Aos colegas do Laboratório de Metrologia Nuclear que de alguma forma colaboraram no bom andamento e execução deste trabalho. Aos meus pais, José Yamazaki e Makina Yamazaki, (em memória), que sempre apoiaram e incentivaram com muita determinação os meus anos de estudo, aproveito esta oportunidade para novamente agradecê-los por tudo, onde eles estiverem. , que mesmo tão distantes, pelos conselhos, incentivo e torcida constantes. Ao Valmiro Guilherme de Santana, pelo seu cuidado, carinho, estímulo e suporte pessoal contínuo, que me fizeram superar os obstáculos. Ao Instituto de Pesquisas Energéticas e Nucleares, na pessoa do Superintendente Dr. Wilson Aparecido Parejo Calvo, pela oportunidade oferecida.A todos que direta ou indiretamente colaboraram na execução e realização deste trabalho. RESUMO YAMAZAKI, I.M. Padronização em sistema primário por coincidências 4e determinação das intensidades de emissão gama por decaimento dos radionuclídeos 64 Cu e 166 Ho. 2019. 150 p. Tese (Doutorado em Tecnologia Nuclear), Instituto de de 0,472 (10) % apresentando um bom acordo com os dados da literatura. A probabilidade de emissão gama por decaimento do fóton gama de 1379,45 keV do 166 Ho foi de 0,936 (4) %. Por meio destas medidas foi possível também a determinação das intensidades relativas de outros fótons emitidos por este radionuclídeo. Os resultados obtidos foram concordantes com a literatura dentro da incerteza experimental. Palavras chaves: Padronização primária do 64 Cu e 166 Ho, sistema de coincidências 4(PC)- , probabilidade de emissão gama ABSTRACT YAMAZAKI, I.M. Primary standardisation of 64 Cu and 166 Ho radionuclides in the 4PC coincidence system and determination of its gamma-ray emission probability per decay . 2019. 150 p. Tese (Doutorado em Tecnologia Nuclear), Instituto de Pesquisas Energéticas e Nucleares, São Paulo. The procedure followed by the Nuclear Metrology Laboratory (LMN) at the Nuclear and EnergyResearch Institute (IPEN) for the primary standardization of 64 Cu and 166 Ho is described. These radionuclides are widely applied to Nuclear Medicine such as in diagnostic investigations and in radiotherapy. The absolute activity of both radionuclides were determined by the efficiency extrapolation method applied to 4(PC)- coincidence counting system using a proportional counter in 4 geometry coupled with NaI(Tl) scintillation counter. The primary standardisation of 64 Cu for the conventional coincidence counting, the events were registered using a Time to Amplitude Converter (TAC) system a...

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Standardisation of 64Cu using a software coincidence counting system

Cited by 7 publications

References 12 publications

Standardization of 64Cu activity

Standardization of 64Cu activity

Monte Carlo modelling of live-timed anticoincidence (LTAC) counting for Cu-64

Padronização em sistema primário por coincidências 4πβ-γ e determinação das intensidades de emissão gama por decaimento dos radionuclídeos Cu-64 e Ho-166

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Standardisation of 64Cu using a software coincidence counting system

Cited by 7 publications

References 12 publications

Standardization of 64Cu activity

Standardization of 64Cu activity

Monte Carlo modelling of live-timed anticoincidence (LTAC) counting for Cu-64

Padronização em sistema primário por coincidências 4&pi;&beta;-&gamma; e determinação das intensidades de emissão gama por decaimento dos radionuclídeos Cu-64 e Ho-166

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Padronização em sistema primário por coincidências 4πβ-γ e determinação das intensidades de emissão gama por decaimento dos radionuclídeos Cu-64 e Ho-166