Standard Ovarian Stimulation Protocols and Their Outcomes

Mongkolchaipak, Suchada

doi:10.1007/978-3-319-53454-1_7

Cited by 1 publication

(1 citation statement)

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“…Infertility is one of the most frequent health problems in the world, resulting from genetic or pathological diseases, prompting ongoing research and studies in the field of assisted reproductive technology (ART) to find the best treatment options possible (Mongkolchaipak, S [1] ). Despite the efforts of fertility clinics worldwide in the field of ART, there are an estimated 13% of couples influenced by infertility.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Pregnancy-Associated Plasma Protein (PAPP-A) in Serum and Follicular Fluid with Oocyte and Embryo Quality in PCOS and non-PCOS Women Undergoing ICSI Cycle

Salim Altimimi,

Ali Jwad,

Abdulwahid Mohammed

2021

IJEIR

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Pregnancy-Associated Plasma Protein (PAPP-A) is a zinc metalloproteinase in the insulin growth factor system (IGFs) produced by the syncytiotrophoplast region of the placenta. It plays a critical function in the cleavage of IGFBP4. In the ovary IGFs, it regulates follicular and oocyte maturation, and steroidogenesis. While in polycystic ovarian syndrome (PCOS) Hyperinsulinemia and hyperandrogenemia it causes follicular environment changes and early ovulation resulting in lower oocyte and embryo quality in patients and this will decrease the success of pregnancy in women enrolled in the ICSI cycle. The present study aimed to assess the relationship of PAPP-A levels in serum and follicular fluid in women with PCOS and non-PCOS with oocyte and embryo quality in women undergoing ICSI cycle. 45 infertile Iraqi women were enrolled. Women with PCOS had to meet at least two of the three criteria set by the Rotterdam ESHRE/ASRMS criteria, the age of the included women ranged between 20-45 years. In non-PCOS patients, PAPP-A has higher level in serum and follicular fluid but without a statistically significant difference matching with PCOS group. In addition, there was no significant correlation between PAPP-A levels in serum and follicular fluid with oocytes and embryo characteristics. However, PAPP-A levels are higher in serum and follicular fluid in women with positive pregnancy but without significant differences. PAPP-A had no correlation with oocyte and embryo quality.

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Section: Introductionmentioning

confidence: 99%