Standard object recognition memory and “what” and “where” components: Improvement by post-training epinephrine in highly habituated rats

Jurado-Berbel, Patricia; David, Cristhian; Torras-Garcia, Meritxell; Coll-Andreu, Margalida; Portell-Cortès, Isabel

doi:10.1016/j.bbr.2009.09.036

Cited by 19 publications

(25 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with this argument, there is evidence from the animal literature that post-learning induction of epinephrine (e.g., Jurado-Berbel, Costa-Miserachs, Torras-Garcia, Coll-Andreu, & Portell-Cortes, 2010) or norepinephrine (Roozendaal, Castello, Vedana, Barsegyan, & McGaugh, 2008) can enhance memory for neutral information that was the focus of attention shortly before the stress hormone induction. Furthermore, Roozendaal et al (2008) infused norepinephrine or the β-adrenoceptor antagonist propranolol directly into the basolateral amygdala after rats were presented with two versions of a novel object, linking these effects to the amygdala.…”

Section: Arousal-biased Competition In Memory Consolidationmentioning

confidence: 85%

Arousal-Biased Competition in Perception and Memory

Mather

Sutherland

2011

Perspect Psychol Sci

767

770

View full text Add to dashboard Cite

Our everyday surroundings besiege us with information. The battle is for a share of our limited attention and memory, with the brain selecting the winners and discarding the losers. Previous research shows that both bottom-up and top-down factors bias competition in favor of high priority stimuli. We propose that arousal during an event increases this bias both in perception and in long-term memory of the event. Arousal-biased competition theory provides specific predictions about when arousal will enhance and when it will impair memory for events, accounting for some puzzling contradictions in the emotional memory literature.

show abstract

Section: Arousal-biased Competition In Memory Consolidationmentioning

confidence: 85%

Arousal-Biased Competition in Perception and Memory

Mather

Sutherland

2011

Perspect Psychol Sci

767

770

View full text Add to dashboard Cite

show abstract

“…Drugs and other treatments that increase concentrations of epinephrine or glucocorticoids during, or following, learning enhance memory in rats and mice (Gold and van Buskirk, 1978; Introini-Collison et al, 1992; Jurado-Berbel et al, 2010; King and Williams, 2009; Liang et al, 1995; Roozendaal et al, 2006; Williams and McGaugh, 1993; Williams et al, 2000; Williams et al, 1998) as well as human subjects (Cahill and Alkire, 2003; Kuhlmann and Wolf, 2006; Moor et al, 2005; Zoladz et al, 2011). These peripherally acting hormones must, of course, interact with the central nervous system to modulate memory formation.…”

Section: Effects Of Arousal On Peripheral Hormones and Central Norepmentioning

confidence: 99%

Interacting brain systems modulate memory consolidation

McIntyre

McGaugh

Williams

2012

Neuroscience & Biobehavioral Reviews

188

135

View full text Add to dashboard Cite

Emotional arousal influences the consolidation of long-term memory. This review discusses experimental approaches and relevant findings that provide the foundation for current understanding of coordinated interactions between arousal activated peripheral hormones and the brain processes that modulate memory formation. Rewarding or aversive experiences release the stress hormones epinephrine (adrenalin) and glucocorticoids from the adrenal glands into the bloodstream. The effect of these hormones on memory consolidation depends upon binding of norepinephrine to beta-adrenergic receptors in the basolateral complex of the amygdala (BLA). Much evidence indicates that the stress hormones influence release of norepinephrine in the BLA through peripheral actions on the vagus nerve which stimulates, through polysynaptic connections, cells of the locus coeruleus to release norepinephrine. The BLA influences memory storage by actions on synapses, distributed throughout the brain, that are engaged in sensory and cognitive processing at the time of amygdala activation. The implications of the activation of these stress-activated memory processes are discussed in relation to stress-related memory disorders.

show abstract

“…This task relies on the robust neophilic tendency characteristic of rodents and many other animals. This type of task has been used to test a diverse set of questions including, but not limited to the effects of stress (Beck and Luine, 1999; Bowman et al, 2003; Okuda et al, 2004; Scullion et al, 2009; Cazakoff et al, 2010), neuromodulation (Roozendaal et al, 2008; Jurado-Berbel et al, 2010), and aging and gene mutations (Bevins and Besheer, 2006) on memory.…”

Section: Introductionmentioning

confidence: 99%

Stressors impair odor recognition memory via an olfactory bulb-dependent noradrenergic mechanism

Manella

Alperin

Linster

2013

Front. Integr. Neurosci.

View full text Add to dashboard Cite

Non-associative habituation and odor recognition tasks have been widely used to probe questions of social recognition, odor memory duration, and odor memory specificity. Among others, these paradigms have provided valuable insight into how neuromodulation, and specifically norepinephrine/noradrenaline (NE) influences odor memory. In general, NE levels are modulated by arousal, stress, and behavioral state, but there is sparse evidence of a direct relationship between NE and odor memory in adult rodents. The present study uses simple mild psychological stressors (bright light and sound) to modulate NE levels physiologically in order to probe stressors NE-dependent effect on odor recognition memory. In rats with bilateral bulbar cannulations, we show that these stressors modulate olfactory memory and that this effect is at least partially mediated by the olfactory bulb. Specifically, we show that the presence of stressors during the acquisition of odor memory suppresses memory for an odor when tested 30 min after familiarization to that odor. This suppression is blocked by infusing NE antagonists into the olfactory bulb prior to odor acquisition. Additionally, we find that infusion of bulbar NE is sufficient to suppress odor memory in a manner mimicking that of our stressors. These effects are unlikely to be solely mediated by locomotor/exploratory changes produced by stressors, although these stressors influence certain behaviors not directly related to odor investigation. This study provides important information about how behaviorally relevant changes in NE can influence top-down sensory processing and odor memory.

show abstract

Standard object recognition memory and “what” and “where” components: Improvement by post-training epinephrine in highly habituated rats

Cited by 19 publications

References 47 publications

Arousal-Biased Competition in Perception and Memory

Arousal-Biased Competition in Perception and Memory

Interacting brain systems modulate memory consolidation

Stressors impair odor recognition memory via an olfactory bulb-dependent noradrenergic mechanism

Contact Info

Product

Resources

About