Standard Metabolism in the White Mouse

Barboue, H. G.; Trace, J. W.

doi:10.1152/ajplegacy.1936.118.1.77

Cited by 11 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although new Meeh constants and formulas have been reported for rats [8,9], we could find no recent determinations of Meeh constants in mice. Older studies report a wide range in values for k in various sorts of mice, including 9 [10], 10.6 [11], 10.9 [12], and 11.4 [13]. Using such published values would give a potential error of up to 27% in estimated BSA; therefore we sought to define precise values of k for commonly used strains of modern mice.…”

Section: Introductionmentioning

confidence: 99%

Body Surface Area Prediction in Normal, Hypermuscular, and Obese Mice

Cheung

Spalding

Gutierrez

et al. 2009

Journal of Surgical Research

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Body Surface Area Prediction in Normal, Hypermuscular, and Obese Mice

Cheung

Spalding

Gutierrez

et al. 2009

Journal of Surgical Research

View full text Add to dashboard Cite

“…This dose and administration is representative of an environmental exposure to estrogenic EDCs ( Aris et al , 2014 ). Assuming a mouse’s average intake of 5 ml per day and weight of 20 g, this dose equates to 1 µg/kg every second day and will be referred to as 1 µg/kg from here on ( Barbour and Trace, 1936 ). Control female mice (vehicle) were treated with 1% ethanol in phosphate buffered saline through subcutaneous injection or via the drinking water, as no differences in control groups were observed, these cohorts were combined and will be referred to as the vehicle treatment.…”

Section: Methodsmentioning

confidence: 99%

Prenatal exposure to diethylstilbestrol has long-lasting, transgenerational impacts on fertility and reproductive development

Rogers

Chai

Pask

et al. 2023

Toxicological Sciences

View full text Add to dashboard Cite

Significant decreases in fertility have been observed over the past 50 years, with female conception rates dropping by 44% and male sperm counts decreasing by over 50%. This dramatic decrease in fertility can be attributed in part to our increasing exposure to endocrine disrupting chemicals (EDCs). Diethylstilbestrol (DES) is an estrogenic EDC that was prescribed to millions of pregnant women between 1940-1970 and resulted in detrimental reproductive effects in the offspring that were exposed in utero. Women who were exposed to DES in utero experienced higher rates of infertility, pregnancy complications and reproductive cancers. Alarmingly, there is evidence to suggest that these effects may persist in the grandchildren and great grandchildren of exposed women. To define the transgenerational reproductive impacts in females following exposure to DES, gestating mice were exposed to DES and the effects monitored in the female descendants across three generations. There was a trend for reduced pregnancy rate and fertility index seen across the generations and moreover, the anogenital distance (AGD) was significantly reduced up until the third, unexposed generation. The onset of puberty was also significantly affected, with the timing of vaginal opening occurring significantly earlier in DES descendants. These results indicate a transgenerational effect of DES on multiple reproductive parameters including fertility, timing of puberty and AGD. These data have significant implications for more than 50 million DES descendants worldwide as well as raising concerns for the ongoing health impacts caused by exposures to other estrogenic EDCs which are pervasive in our environment.

show abstract

Isolated cleft palate in A/J mice after transitory exposure to drinking‐water deprivation and low humidity in pregnancy

1974

View full text Add to dashboard Cite

When pregnant A/J mice were deprived of drinking water and exposed to circulating dehumidified (dry) air for 72 h starting at gestation day 12, 39% of fetuses alive on day 17 had isolated cleft palate (CP), whereas treatment begun at day 11 gave 23% CP and at day 13 6% CP. A 48-h exposure to dry air with deprivation of drinking water gave 7% CP. Deprivation of water alone for 72 h resulted in 12% CP and for 48 h gave 2 % CP, not significantly above the 1 % CP in controls. All treatments increased the fetal death rate but there was no evidence of an effect on the rate of cleft lip with or without cleft palate, a spontaneous defect in A/J mice. Extraembryonic membranes of day-17 fetuses, after treatment from days 12-15, frequently showed strongly benzidine-positive pigment i n the yolk-sac cavity alongside the vitelline vessels. Only rarely were small amounts of pigment observed in controls. It was thought to be old fetal blood. Fetal red cell and serum loss are discussed in relation to CP resulting from water deprivation and other teratogenic treatments.

show abstract

Standard Metabolism in the White Mouse

Cited by 11 publications

References 0 publications

Body Surface Area Prediction in Normal, Hypermuscular, and Obese Mice

Body Surface Area Prediction in Normal, Hypermuscular, and Obese Mice

Prenatal exposure to diethylstilbestrol has long-lasting, transgenerational impacts on fertility and reproductive development

Isolated cleft palate in A/J mice after transitory exposure to drinking‐water deprivation and low humidity in pregnancy

Contact Info

Product

Resources

About