Standard manufacturing process of Makaradhwaja prepared by Swarna Patra-Varkha and Bhasma

Khedekar, Sanjay; Patgiri, Biswajyoti; Ravishankar, B; Prajapati, PK

doi:10.4103/0974-8520.85741

Cited by 11 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By far the research works concerned on Makaradhwaja ; this is the highest percentage of gold reported till date. This further supports the conclusion of prior resercher[21] as Swarna Varkha was used in the preparation. Duration of trituration of Swarna Pishti , duration of Paka ( Madhyamagni and Tivragni , at the time of sublimation) and to a certain extent, errors in sample preparation may be the reasons for low quantity of gold reported in TM.…”

Section: Discussionsupporting

confidence: 86%

“…Quantity of gold present in TM (7.2976 ppm) was far below the levels reported[21] (268 ppm), although it is nearly equal to the levels reported initially (7.65 ppm). It is to be noted that in first case[21] TM had been prepared from Hingulottha Parada , whereas in other works[8] done it was prepared from by Ashtasamskarita Parada and Dwiguna Balijarana from Patra of Swarna . In the present work, Makaradhwaja was prepared by Ashtasamskarita Parada and subsequently Triguna and Shadguna Balijarana were carried out with Swarna Varkha .…”

Section: Discussioncontrasting

confidence: 55%

“…Recent work carried out in 2009 had concluded that if Makaradhwaja is prepared by least particle size of elemental gold, gold content increases in the finished product. [21]…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pharmaceutical study of Triguna and Shadguna Balijarita Makaradhwaja

Dhundi

Patgiri

Prajapati

et al. 2012

AYU

Self Cite

View full text Add to dashboard Cite

Makaradhwaja is a herbo-minaral drug prepared by Kupipakwa method. In the present study Makaradhwaja was prepared by Triguna and Shadguna Balijarana using Ashtasamskarita Parada. Total five batches of Triguna Makaradhwaja (TM) were prepared by taking 330 g of Kajjali in each batch, average product obtained was 29.12 g. In the preparation of Shadguna Makaradhwaja (SM) too, five batches were prepared, taking 250 g of Kajjali, average product obtained was 16.8 g. The average time taken for flame in TM was 3.01 h and that in SM was 4.58 h. Kupipaka was carried out for 18 and 36 h in TM and SM, respectively. Inductive Coupled Plasma - Optical Emission Spectrometry (ICPOES) revealed the presence of 7.2976 ppm gold in TM, whereas 663.14 ppm in SM.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 55%

See 1 more Smart Citation

Pharmaceutical study of Triguna and Shadguna Balijarita Makaradhwaja

Dhundi

Patgiri

Prajapati

et al. 2012

AYU

Self Cite

View full text Add to dashboard Cite

show abstract

“…[ 15 ] However, Makaradwaja samples received from Gujarat Ayurved University, analyzed in our lab, have been found to contain gold at 20–270 ppm [ Table 1 ]. It has been explained that the variation of gold content depends on the type of gold used[ 16 ] or the extent sulfur used. [ 17 ] Some preparations even report Poorna Chandrodayam (a preparation similar to that of Makaradwaja ) having close to 9% gold!…”

Section: Analysis Of Mercurials Prepared With Sulfurmentioning

confidence: 99%

Researches on mercurial preparations: The prime requirement for their acceptance in medical world

Arunachalam

2015

AYU

View full text Add to dashboard Cite

Ayurvedic and Siddha medicinal preparations containing mercury have been used over centuries in India. The recent WHO guidelines on the use of mercurials as well as actions by other international organizations into eliminating mercury in all forms have put the people practicing Rasa Shastra in a quandary. Active research in the mechanism of curative actions of mercurials is very much essential, to have widespread acceptance of the ancient practice. The toxicity of a substance depends on its bio-availability; the chemical form in which it is present and the biochemical reactions it participates. Mercury is usually administered as mercuric sulfide (Rasasindura or Linga Chendooram) which has a KSP value of 10–54. Despite this extreme insolubility, how mercury becomes bio-available under enzymatic conditions needs to be studied. Its bioaccumulation in critical organs and excretory pathways are to be ascertained. Research is also needed to establish whether Rasasindura or equivalent medicines induce the (excess) synthesis of sulfur containing biomolecules in human systems, which act as cell protectors against free radical-induced cell damage. The antioxidants themselves could be the curative agents; mercury being just a catalyst. It may also be possible that the exposure to mercury, even in very small amounts, could lead to the synthesis of specific metallothioneins in the human system, helping to detoxify the mercury exposure. The author is of the opinion that Ayurvedic practitioners/researchers should carry out long-term follow-up studies on human patients. The superiority of mercury based Ayurvedic preparations, as against modern allopathic medicines, in providing rapid and long lasting cure for specific diseases needs to document and published. In the absence of such supportive research literature, the use of mercury will become untenable, even for medicinal purposes.

show abstract

“…Specific action on cell-mediated immunity is proved by its immune-modulator action [ 5 ]. In experimental and clinical studies, it is found effective in diabetes [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic activity of traditional Indian gold containing preparation: Shadguna Balijarita Makaradhwaja on streptozotocin induced diabetic rats.

Khedekar

Rukkudin

Ravishankar

et al. 2016

J Intercult Ethnopharmacol

Self Cite

View full text Add to dashboard Cite

Background:Makaradhwaja a gold containing mercurial preparation used for diabetes mellitus in indigenous system of medicine. It is a popular aphrodisiac and rejuvenator traditional medicine. It is prepared by using processed gold, mercury and sulfur in different ratios by applying intermittent heating pattern in Valuka Yantra.Objectives:The aim of the study was to evaluate anti-diabetic effect of Shadguna Balijarita Makaradhwaja (SBM) on streptozotocin (STZ) induced diabetic rats.Materials and Methods:Diabetes was induced to normal rats by injecting STZ in dose 40 mg/kg. Powdered SBM and dried extract of Tinospora cordifolia were mixed with honey and administered orally for 20 days at dose 2.63 mg/kg and 42.34 mg/kg body weight, respectively. The effects of treatment on body weight changes and blood glucose levels were quantified on day 1, 5, 10, 15 and 21 of the experiments. On the 21st day, animals were sacrificed and gross histopathological changes in liver, kidney and pancreas were illustrated. Blood sugar level, glyacated hemoglobin, blood urea, serum cholesterol, serum creatinine, serum triglyceride and serum protein were estimated with standard methods. The study was conducted in the year 2011.Results:Test drug observed significant decrease (P < 0.001) in glyacated hemoglobin level compared to diabetic control rats. Blood sugar level of test drug group shown a significant decrease (279.11 ± 57.95) compared with diabetic rats.Conclusion:The present study demonstrates that SBM and dried extract of T. cordifolia with honey significantly reduces the blood glucose level and shows anti-diabetic effect.

show abstract

Standard manufacturing process of Makaradhwaja prepared by Swarna Patra-Varkha and Bhasma

Cited by 11 publications

References 0 publications

Pharmaceutical study of Triguna and Shadguna Balijarita Makaradhwaja

Pharmaceutical study of Triguna and Shadguna Balijarita Makaradhwaja

Researches on mercurial preparations: The prime requirement for their acceptance in medical world

Antidiabetic activity of traditional Indian gold containing preparation: Shadguna Balijarita Makaradhwaja on streptozotocin induced diabetic rats.

Contact Info

Product

Resources

About