Standard Liver Volume-Predicting Formulae Derived From Normal Liver Volume in Children Under 18 Years of Age

Abstract

Background: Standard liver volume (SLV) is important in risk assessment for major hepatectomy. We aimed to investigate the growth patterns of normal liver volume with age and body weight (BW) and summarize formulae for calculating SLV in children.Methods: Overall, 792 Chinese children (<18 years of age) with normal liver were enrolled. Liver volumes were measured using computed tomography. Correlations between liver volume and BW, body height (BH), and body surface area (BSA) were analyzed. New SLV formulae were selected from different regression models; they were assessed by multicentral validations and were compared.Results: The growth patterns of liver volume with age (1 day−18 years) and BW (2–78 kg) were summarized. The volume grows from a median of 139 ml (111.5–153.6 in newborn) to 1180.5 ml (1043–1303.1 at 16–18 years). Liver volume was significantly correlated with BW (r = 0.95, P < 0.001), BH (r = 0.92, P < 0.001), and BSA (r = 0.96, P < 0.001). The effect of sex on liver volume increases with BW, and BW of 20 kg was identified as the optimal cutoff value. The recommended SLV formulae were BW≤20 kg: SLV = 707.12 × BSA1.09; BW>20 kg, males: SLV = 691.90 × BSA1.06; females: SLV = 663.19 × BSA1.04.Conclusions: We summarized the growth patterns of liver volume and provided formulae predicting SLV in Chinese children, which is useful in assessing the safety of major hepatectomies.

A phase I/II study on intracerebroventricular tralesinidase alfa in patients with Sanfilippo syndrome type B

“…Two-tailed, paired t-tests and linear correlation analyses were performed using GraphPad Prism 9. (13,14,36,37). MRI data were collected as described in the Methods section.…”

“…Because liver and spleen volumes increase linearly versus both age and BSA, these volumes were normalized to BSA calculated using the Mosteller formula to allow for comparison among subjects ranging from 2 to 9 years of age (12). Normal ranges for BSA-corrected liver and spleen volumes were estimated based on literature (13,36,37). ADA bind to both sulfo-tagged and biotinylated molecules to form an antibody complex bridge.…”

“…Liver (A), spleen (B), and brain subregions (C, D) were measured by MRI on weeks 1 (baseline), 24 and 48. Ranges for non-affected subjects were defined based on previous publications(13,14,36,37). MRI data were collected as described in the Methods section.…”

Application of 3D Simulation Software in Chemotherapy and Hepatoblastoma Surgery in Children

“…At the same time, the software can compare and analyze the individualized 3D reconstruction data and operation planning scheme of liver tumor patients with a digital model of typical tumor cases in the equipment database, plan the operation scheme with the help of artificial intelligence technology, and provide reference guide for selecting the most accurate operation scheme ( 17 ). Comparing the reference range of the normal liver volume of children of different ages in the database and analyzing the percentage of the functional residual liver volume of the operation scheme in the normal standard liver volume of the same age can provide important help for judging the safety range of the residual liver after hepatectomy ( 34 ). The learning curve of software operation is short and does not need professional imaging technicians.…”

From diagnosis to treatment of mucopolysaccharidosis type VI: A case report with a novel variant, c.1157C>T (p.Ser386Phe), in ARSB gene

“…bThe volume of liver and spleen was measured by computed tomography scan. c Reference ranges of volume of liver and spleen were cited from articles of Yang et al[5] and Prassopoulos and Cavouras[6]. GAG, glycosaminoglycan; FVC, forced vital capacity; FEV1, forced expiratory volume in one second; FEF25-75, forced expiratory flow at 25-75% of the pulmonary volume; MR, mitral regurgitation; AR, aortic regurgitation; LVM, left ventricular mass; LVMI, LVM index.…”