Standard Growth Curves in Prader-Willi Syndrome in Japan

Abstract

Abstract.We report standard growth curves in Japanese Prader -Willi syndrome (PWS) for height. Growth patterns for height are quite different between PWS and normal controls ,showing the mean height in PWS ranging at -2SD of normal control data until pubertal age and dropping off far below -2SD of normal control after puberty . These data indicate that the pathogenesis of the short stature of PWS originates from both chromosomal abnormalities and hypogonadism.In addition to these factors we suspect that bone dysplasia seen in patients with this syndrome is also one of the factors in the short stature of PWS .