Standard and novel imaging methods for multiple myeloma: correlates with prognostic laboratory variables including gene expression profiling data

Waheed, Sarah; Mitchell, Alan; Usmani, Saad Z.; Epstein, Joshua; Yaccoby, Shmuel; Nair, Bijay; Hemert, Rudy Van; Angtuaco, Edgardo J.; Brown, Tracy L.; Bartel, Twyla; McDonald, James E.; Anaissie, Elias; Rhee, Frits van; Crowley, John; Barlogie, Bart

doi:10.3324/haematol.2012.066555

Cited by 82 publications

(70 citation statements)

References 50 publications

(60 reference statements)

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“…4,5 Similarly, positron emission tomography in combination with CT (PET/CT) is superior to conventional radiography in the detection of lytic disease, while wholebody magnetic resonance imaging (MRI) accurately depicts the marrow involvement in MM patients. 6,7 We stress that MRI depicts bone marrow involvement, while CT and skeletal survey reveals lytic lesions. However, there are some issues that need to be clarified when using such sensitive techniques.…”

Section: Imaging For the Diagnosis And Follow Up Of Myeloma Patientsmentioning

confidence: 99%

European Myeloma Network Guidelines for the Management of Multiple Myeloma-related Complications

et al. 2015

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Section: Imaging For the Diagnosis And Follow Up Of Myeloma Patientsmentioning

confidence: 99%

European Myeloma Network Guidelines for the Management of Multiple Myeloma-related Complications

et al. 2015

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“…44 Concerning EMD, the authors found an increased incidence of EMD in patients with a high-risk gene expression profile or cytogenetic abnormalities. 56 The different prognostic studies on PET/CT are summarized in the Online Supplementary Table S1.…”

Section: © F E R R a T A S T O R T I F O U N D A T I O Nmentioning

confidence: 99%

“…In contrast, WBXR shows more lesions in the skull or appendicular regions in 5% of the patients. 8,43,44 CT is also able to assess the fracture risk and the presence of extramedullary lesions.…”

Section: Diagnosismentioning

confidence: 99%

The role of positron emission tomography-computed tomography and magnetic resonance imaging in diagnosis and follow up of multiple myeloma

et al. 2014

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“…Radiological techniques have long been a part of disease assessments; plain radiographic skeletal survey and magnetic resonance imaging (MRI) of the spine have an established role in the diagnosis, staging and assessment of insufficiency fracture risk of patients (Durie et al , 2006; D'Sa et al , 2007; Hanrahan et al , 2010). The use of cross‐sectional imaging techniques [computed tomography (CT), positron emission tomography (PET)‐CT and MRI] are confirmed to be more sensitive than plain radiography in the detection of bone lesions (Zamagni et al , 2007; Bartel et al , 2009; Regelink et al , 2013; Waheed et al , 2013). Importantly, the detection of more than one focal lesion (FL) on cross‐sectional imaging is now considered to fulfill the criteria for symptomatic disease deserving of treatment (Rajkumar et al , 2014).…”

mentioning

confidence: 99%

Whole body magnetic resonance imaging in newly diagnosed multiple myeloma: early changes in lesional signal fat fraction predict disease response

et al. 2016

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SummaryCross‐sectional imaging techniques are being increasingly used for disease evaluation in patients with multiple myeloma. Whole body magnetic resonance imaging (WB‐MRI) scanning is superior to plain radiography in baseline assessment of patients but changes following treatment have not been systematically explored. We carried out paired WB‐MRI scans in 21 newly diagnosed patients prior to, and 8‐weeks after, starting chemotherapy, and analysed stringently selected focal lesions (FLs) for parametric changes. A total of 323 FLs were evaluated, median 20 per patient. At 8 weeks, there was a reduction in estimated tumour volume (eTV), and an increase in signal fat fraction (sFF) and apparent diffusion coefficient (ADC) in the group as a whole (P < 0·001). Patients who achieved complete/very good partial response (CR/VGPR) to induction had a significantly greater increase in sFF compared to those achieving ≤ partial response (PR; P = 0·001). When analysed on a per‐patient basis, all patients achieving CR/VGPR had a significant sFF increase in their FL's, in contrast to patients achieving ≤PR. sFF changes in patients reaching maximal response within 100 days (fast responders) were greater compared to slow responders (P = 0·001). Receiver Operator Characteristic analysis indicated that sFF changes at 8 weeks were the best biomarker (area under the Curve 0·95) for an inferior response (≤PR). We conclude that early lesional sFF changes may provide important information on depth of response, and are worthy of further prospective study.

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Standard and novel imaging methods for multiple myeloma: correlates with prognostic laboratory variables including gene expression profiling data

Cited by 82 publications

References 50 publications

European Myeloma Network Guidelines for the Management of Multiple Myeloma-related Complications

European Myeloma Network Guidelines for the Management of Multiple Myeloma-related Complications

The role of positron emission tomography-computed tomography and magnetic resonance imaging in diagnosis and follow up of multiple myeloma

Whole body magnetic resonance imaging in newly diagnosed multiple myeloma: early changes in lesional signal fat fraction predict disease response

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