Stalking new vaccines: Methods that target the stems of viral proteins could put universal vaccines within reach

Arnold, Carrie

doi:10.1038/nm1117-1248

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…The most widely used strategy is proline mutation [88], which influenced the design of the vaccine critically during the ongoing pandemic. Encouragingly, the S-2P strategy (comprising proline substitutions) is broadly applicable and could be regarded as a universal manner in different coronaviruses [89,90]. As a key target antigen for vaccine development, the spike protein of coronaviruses is in a metastable prefusion conformation, and maintaining its neutralization-sensitive epitopes is indispensable to improve antigenicity and protein expression.…”

Section: Structure-guided Vaccine Designmentioning

confidence: 99%

Advanced Vaccine Design Strategies against SARS-CoV-2 and Emerging Variants

et al. 2023

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Vaccination is the most cost-effective means in the fight against infectious diseases. Various kinds of vaccines have been developed since the outbreak of COVID-19, some of which have been approved for clinical application. Though vaccines available achieved partial success in protecting vaccinated subjects from infection or hospitalization, numerous efforts are still needed to end the global pandemic, especially in the case of emerging new variants. Safe and efficient vaccines are the key elements to stop the pandemic from attacking the world now; novel and evolving vaccine technologies are urged in the course of fighting (re)-emerging infectious diseases. Advances in biotechnology offered the progress of vaccinology in the past few years, and lots of innovative approaches have been applied to the vaccine design during the ongoing pandemic. In this review, we summarize the state-of-the-art vaccine strategies involved in controlling the transmission of SARS-CoV-2 and its variants. In addition, challenges and future directions for rational vaccine design are discussed.

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Section: Structure-guided Vaccine Designmentioning

confidence: 99%