Staging significance of bone invasion in small-sized (4cm or less) oral squamous cell carcinoma as defined by the American Joint Committee on Cancer

Kuk, Su Kyung; Yoon, Hye Jung; Hong, Seong Doo; Hong, Seong Wook; Lee, Jae Il

doi:10.1016/j.oraloncology.2016.01.014

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…However, tumours presented with both buccal and lingual bone invasion had a significantly worse prognosis. 72 Okura et al reviewed 345 patients with mandibular gingival OSCC and determined that mandibular canal invasion was an independent predictor of decreased survival rate, whereas medullary bone invasion was an insignificant prognostic indicator with respect to the survival of patients. However, medullary bone invasion was significantly associated with distant metastasis.…”

Section: Histopathological Factorsmentioning

confidence: 99%

Clinico-pathological prognosticators in oral squamous cell carcinoma

Majumdar¹,

Patil

Sarode

et al. 2017

Translational Research in Oral Oncology

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Despite diagnostic and therapeutic advancements, mortality and morbidity rates in the patients diagnosed with oral cancer remain static. Hence, an understanding of the factors that predict the progression of oral cancer appears to be useful in deciding on the most appropriate therapy, thereby improving survival. To do so in practice, a critical knowledge of prognostic markers that have high sensitivity is essential. Though recent research has introduced newer molecular markers, challenging the conventional prognostic assessment methods their universal application is yet to be determined. In practice, clinical and histopathological parameters are widely used for the selection of treatment strategies and for the determination of prognosis in oral cancer patients. A literature search yielded a multitude of parameters to be involved in the determination of prognosis of a patient. Based on published evidence, factors of significance were pTNM, tumour volume, depth of invasion, surgical margin status, tumour budding, vascular and perineural invasion, medullary bone invasion, extracapsular spread and the presence of distant metastasis.

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Section: Histopathological Factorsmentioning

confidence: 99%

Clinico-pathological prognosticators in oral squamous cell carcinoma

Majumdar¹,

Patil

Sarode

et al. 2017

Translational Research in Oral Oncology

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“…Oral squamous cell carcinoma (OSCC), especially gingival OSCC (GOSCC), frequently invades the mandible or maxilla; jawbone destruction due to OSCC decreases the quality of life of patients (1)(2)(3)(4). OSCC invades subgingival connective tissue, destroying the jawbone via vertical infiltration or reaching the periodontal ligament (PDL) tissue via horizontal infiltration.…”

Section: Introductionmentioning

confidence: 99%

“…The nature of OSCC bone destruction is hypothesized to be a result of differential activation of osteoclasts by cancer cells, but the mechanism is unknown. To date, several studies have reported mechanisms of bone resorption in OSCC, which were relevant with the size of OSCC and the expression level of osteoprotegerin ( 3 , 4 ). However, the complete picture of bone resorption in OSCC is not yet clear.…”

Section: Introductionmentioning

confidence: 99%

Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line‑derived xenograft model

et al. 2022

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The cancer stroma regulates bone invasion in oral squamous cell carcinoma (OSCC). However, data on normal stroma are limited. In the present study, the effects of gingival and periodontal ligament tissue-derived stromal cells (G-SCs and P-SCs, respectively) and human dermal fibroblasts (HDFs) on bone resorption and osteoclast activation were assessed using hematoxylin and eosin and tartrate-resistant acid phosphatase staining in a cell line-derived xenograft model. The results demonstrated that G-SCs promoted bone invasion and osteoclast activation and inhibited osteoclast proliferation following crosstalk with the human OSCC HSC-3 cell line, whereas P-SCs inhibited bone resorption and promoted osteoclast proliferation in vitro but had a minimal effect on osteoclast activation both in vitro and in vivo following crosstalk with HSC-3 cells. Furthermore, the effects of G-SCs, P-SCs and HDFs on protein expression levels of matrix metalloproteinase (MMP)-9, membrane type 1 MMP (MT1-MMP), Snail, parathyroid hormone-related peptide (PTHrP) and receptor activator of NF-κB ligand (RANKL) in HSC-3 cells in OSCC bone invasion regions were assessed using immunohistochemistry. The results demonstrated that G-SCs had a more prominent effect on the expression of MMP-9, MT1-MMP, Snail, PTHrP, and RANKL, whereas P-SCs only promoted RANKL and PTHrP expression and exerted a minimal effect on MMP-9, MT1-MMP and Snail expression. The potential genes underlying the differential effects of G-SCs and P-SCs on bone invasion in OSCC were evaluated using a microarray, which indicated that cyclin-dependent kinase 1, insulin, aurora kinase A, cyclin B1 and DNA topoisomerase II alpha underlaid these differential effects. Therefore, these results demonstrated that G-SCs promoted bone invasion in OSCC by activating osteoclasts on the bone surface, whereas P-SCs exerted an inhibitory effect. These findings could indicate a potential regulatory mechanism for bone invasion in OSCC.

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Staging for Specimens of Squamous Cell Carcinoma of Skin

2017

Diagnostic Pathology: Neoplastic Dermatopathology

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Staging significance of bone invasion in small-sized (4cm or less) oral squamous cell carcinoma as defined by the American Joint Committee on Cancer

Cited by 7 publications

References 20 publications

Clinico-pathological prognosticators in oral squamous cell carcinoma

Clinico-pathological prognosticators in oral squamous cell carcinoma

Investigation of bone invasion and underlying mechanisms of oral cancer using a cell line‑derived xenograft model

Staging for Specimens of Squamous Cell Carcinoma of Skin

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