Staging, Response to Therapy, and Restaging of Lymphomas with 18F-FDG PET

Altamirano, Javier; Reyes‐Esparza, Jorge; Salazar, Jaime de; Calvo, Pedro Sobrevilla; Vera, Silvia Rivas; Revelo, Juan Ramón Chalapud; Estrada, Gisela

doi:10.1016/j.arcmed.2007.07.003

Cited by 11 publications

(2 citation statements)

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“…Being invasive, each has its own list of complications. 18 F-FDG PET-CT, a recently introduced noninvasive imaging modality, has been included in the staging of lymphoma and has been found to have higher sensitivity than CT.[13] However, FDG is not specific for detecting malignant conditions. It has been shown that inflammatory cells also show avidity for FDG.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mediastinal lymph nodes using ¹⁸ F-FDG PET-CT scan and its histopathologic correlation

et al. 2011

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AIMS AND OBJECTIVES:To determine the efficacy of integrated 18F-fluorodeoxy glucose positron emission tomography-computed tomography (18F-FDG PET-CT) in the evaluation and characterization of mediastinal lymph nodes into benign and malignant pathology.METHODS:Thirty-five patients with mediastinal lymphadenopathies without primary neoplastic or infective lung pathologies were included in the study. The lymph nodes were detected on contrast-enhanced CT scan of the chest. All patients underwent 18F-FDG PET-CT scan for evaluation of mediastinal lymph nodes. Results of PET-CT were compared with histopathology of the lymph nodes and sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated.STATISTICAL ANALYSIS:The data were collected prospectively and analyzed using (SPSS Inc., Chicago, IL) 11.5 software.RESULTS:Histopathology results in 35 patients revealed tuberculosis in 12, sarcoidosis in 8, and lymphoma in 15. Maximum standardized uptake value (SUVmax) of the benign lymph nodes ranged from 2.3 to 11.8 with a mean±standard deviation (SD) of 5.02±3.26. SUVmax of the malignant lymph nodes ranged from 2.4 to 34 with a mean±SD of 10.8±8.12. There was a statistically significant difference between benign and malignant pathology (P<0.0059). 18F-FDG PET-CT has sensitivity of 93% and specificity of 40% with SUVmax 2.5 as the cutoff. We found the optimal SUVmax cutoff to be 6.2 as determined by the receiver–operator characteristic curve. With 6.2 as cutoff, the sensitivity, specificity, and accuracy were 87%, 70%, and 77%, respectively.CONCLUSIONIn countries where tuberculosis and other granulomatous diseases are endemic, SUVmax cutoff value of 2.5 has low specificity. Increasing the cutoff value can improve the specificity, while maintaining an acceptable sensitivity.

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Section: Discussionmentioning

confidence: 99%

Evaluation of mediastinal lymph nodes using ¹⁸ F-FDG PET-CT scan and its histopathologic correlation

et al. 2011

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“…Allo stato attuale la PET/TC con FDG è la metodica più adeguata nella valutazione dell'estensione di malattia e nel follow-up in pazienti con linfoma e ha mostrato, inoltre, un'elevata accuratezza diagnostica nella ristadiazione dopo il trattamento iniziale. La PET con FDG permette altresì di predire in maniera precoce la risposta alla terapia e di valutare masse residue dopo chemioterapia o radioterapia [11,23,24].…”

Section: Linfomaunclassified

Recent applications of nuclear medicine in diagnostics (I part)

Treglia¹,

Cason²,

Fagioli³

2013

Ital J Med

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Introduction: Aim of this review is to describe the recent applications of nuclear medicine techniques in diagnostics, particularly in oncology. Materials and methods: We reviewed scientific literature data searching for the current role of tomographic nuclear medicine techniques (SPECTand PET) in oncology and summarized the main applications of these techniques. Results: Nuclear medicine techniques have a key role in oncology allowing early diagnosis of many tumours, an accurate staging of disease and evalutation of treatment response. Hybrid SPECT/CT and PET/CT imaging systems now provide metabolic and functional information from SPECTor PETcombined with the high spatial resolution and anatomic information of CT. The most frequent applications of SPECT/CT in oncology concern thyroid tumours, neuroendocrine tumours, bone metastases and lymph node mapping. Furthermore the evaluation of many tumours may benefit from PET/CT imaging. Discussion: The recent development of new radiopharmaceuticals and the growth of hybrid tomographic devices, such as SPECT/CT and PET/CT, now permits molecular imaging of biologic processes at the cellular level to improve both the diagnosis and treatment of many tumours.

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Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies

Aldin

Umlauff

Estcourt

et al. 2019

Cochrane Database of Systematic Reviews

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Staging, Response to Therapy, and Restaging of Lymphomas with 18F-FDG PET

Cited by 11 publications

References 16 publications

Evaluation of mediastinal lymph nodes using ¹⁸ F-FDG PET-CT scan and its histopathologic correlation

Evaluation of mediastinal lymph nodes using ¹⁸ F-FDG PET-CT scan and its histopathologic correlation

Recent applications of nuclear medicine in diagnostics (I part)

Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies

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Staging, Response to Therapy, and Restaging of Lymphomas with 18F-FDG PET

Cited by 11 publications

References 16 publications

Evaluation of mediastinal lymph nodes using 18 F-FDG PET-CT scan and its histopathologic correlation

Evaluation of mediastinal lymph nodes using 18 F-FDG PET-CT scan and its histopathologic correlation

Recent applications of nuclear medicine in diagnostics (I part)

Interim PET-results for prognosis in adults with Hodgkin lymphoma: a systematic review and meta-analysis of prognostic factor studies

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Evaluation of mediastinal lymph nodes using ¹⁸ F-FDG PET-CT scan and its histopathologic correlation

Evaluation of mediastinal lymph nodes using ¹⁸ F-FDG PET-CT scan and its histopathologic correlation