Staging of Lung Cancer

Wynants, Jokke; Stroobants, Sigrid; Dooms, Christophe; Vansteenkiste, Johan

doi:10.1016/j.cpet.2006.10.002

Cited by 4 publications

(6 citation statements)

References 95 publications

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“…The sensitivity, specifi city, positive predictive value, and negative predictive value of integrated PET/CT for detecting presumed malignant extrathoracic lesions was 98, 92, 89 and 98%, respectively. These values were better than those obtained by PET alone (98, 22, 75, and 89, respectively) and CT alone (98, 18, 71 and 89, respectively) [20].…”

Section: Clinical S Tagingmentioning

confidence: 63%

Diagnosis, staging and treatment of patients with non-small cell lung cancer for the surgeon

Bryant

Cerfolio

2009

Indian J Surg

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Section: Clinical S Tagingmentioning

confidence: 63%

Diagnosis, staging and treatment of patients with non-small cell lung cancer for the surgeon

Bryant

Cerfolio

2009

Indian J Surg

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“…The superiority of FDG-PET over CT in the evaluation of mediastinal lymph nodes has been proven in metaanalytic studies [10,11]. In a prospective study with 102 patients, the sensitivity and specificity of FDG-PET in the detection of mediastinal lymph node metastases was found to be 91% and 86% respectively [12].…”

Section: Discussionmentioning

confidence: 99%

“…Al-Sarraf et al have found that, even when not in its active stage, exposure to tuberculosis led to an 8 fold increase in false positivity [20]. On the other hand, the low spatial resolution of the camera (low sensitivity for objects under 7 mm) and diabetes may lead to false negativity [11,20]. Additionally, PET/CT is still not as widely available as CT or MRI.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of diffusion weighted MRI parameters of mediastinal lymph nodes with PET/CT in lung cancer patients

Bugdayci¹,

Kodalli²,

Dede³

et al. 2014

MMJ

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Objective:We have compared diffusion-weighted magnetic resonance imaging (DW-MRI) properties of mediastinal lymph nodes in lung cancer patients with positron emission tomography/ computed tomography (PET/CT) findings.Patients and Methods: Twenty-one consecutive untreated patients with lung cancer were included. DW-MRI was performed on a 1,5T scanner with b values of 50, 500 and 1000. Additional MR imaging was performed for anatomical correlation.Results: A total of 47 lymph nodes were analyzed. While no correlation was found between minimum apparent diffusion coefficient (ADC) values (ADCmin) of lymph nodes and their maximum standardized uptake values (SUVmax) on PET/CT, ADCmin ratios of lymph nodes to main lesion (ADCmin Node/ Lesion) (r = -0.407; p = 0.005) and lymph node to cerebrospinal fluid (ADCmin Node/CSF) (r = -0.364; p = 0.012) were correlated with SUVmax. Cutoff values for DW-MRI parameters were determined using ROC analysis. Six lymph nodes were histopathologically examined. Both methods correctly identified one metastatic and two metastasis negative lymph nodes, while staging one lymph node with granulomatous change as metastasis positive. Two metastasis negative lymph nodes, reported as suspicious on PET/CT, were correctly staged on DW-MRI.Conclusion: Our findings indicate that DW-MRI could be at least as valuable as PET/CT in mediastinal staging of patients with lung cancer.

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“…Thus, imaging techniques play a crucial role in the diagnosis, staging and follow-up of patients with lung cancer. (Hansell DM et al, 2010) and (Wynants J et al, 2007).…”

Section: Computed Tomographymentioning

confidence: 99%