Staging of cutaneous melanoma

Mohr, Peter; Eggermont, Alexander; Hauschild, Axel; Buzaid, Antônio C.

doi:10.1093/annonc/mdp256

Cited by 83 publications

(66 citation statements)

References 52 publications

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“…Los individuos identificados con alto riesgo para presentar melanoma cutáneo deben ser incluidos en un programa de vigilancia (46).…”

Section:  Melanoma Maligno De La Piel -Melanoma Cutáneo (Mc)unclassified

“…El uso de camas solares, lámparas de bronceado y cámaras bronceadoras también están involucrados como factores de riesgo para el MC (19,46,51).…”

Section: Prevención Primaria Y Autocuidado De La Pielunclassified

“…Prevención secundaria (46,47,48,49,50,51) Las fotografías secuenciales son básicas para el seguimiento de nevos sospechosos en los individuos con gran número de nevos y nevos displaśicos.…”

Section: Prevención Primaria Y Autocuidado De La Pielunclassified

“…Criterios de referencia y vigilancia (5,19,46,48,51) Las lesiones o nevos pigmentadas sospechosas evaluadas con la lista de cotejo de los 7 puntos y/o el sistema ABCDE, ante la presencia de cualquier criterio mayor en la lista de los 7 puntos o cualquiera del sistema ABCDE, se deben considerar como una indicación de referencia al dermatólogo. Si presenta un criterio menor positivo se debe considerar como sospechoso y mantener en vigilancia estrecha.…”

Section: Seguimiento De Los Individuos Con Alto Riesgounclassified

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Cáncer de piel: Una realidad cotidianamente ignorada.

Piñeros

Osorio

2017

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INTRODUCCIÓNLa piel es el mayor órgano del cuerpo humano. Ocupa aproximadamente 2 m 2 y su espesor varía entre los 0,5 mm (en los párpados) y los 4 mm (en el talón). Su peso aproximado es de 5 kg. Actúa como barrera protectora que aísla al organismo del medio que lo rodea, protegiéndolo y contribuyendo a mantener íntegras sus estructuras, al tiempo que actúa como sistema de comunicación con el entorno.Dado el tamaño y características de este órgano, podemos afirmar que el cáncer de piel es la patología tumoral maligna más común, especialmente en sujetos de raza blanca como lo veremos más adelante (1, 2).

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“…Los individuos identificados con alto riesgo para presentar melanoma cutáneo deben ser incluidos en un programa de vigilancia (46).…”

Section:  Melanoma Maligno De La Piel -Melanoma Cutáneo (Mc)unclassified

“…El uso de camas solares, lámparas de bronceado y cámaras bronceadoras también están involucrados como factores de riesgo para el MC (19,46,51).…”

Section: Prevención Primaria Y Autocuidado De La Pielunclassified

Section: Seguimiento De Los Individuos Con Alto Riesgounclassified

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Cáncer de piel: Una realidad cotidianamente ignorada.

Piñeros

Osorio

2017

carta comunitaria

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“…Additional imaging modalities that may be used for visualization, staging, and assessment of regional nodal status are CT, ultrasound, MRI, and 18 F-FDG PET (6,7). Each of these techniques has limitations as diagnostic or prognostic tools for melanoma.…”

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confidence: 99%

Improved Detection of Regional Melanoma Metastasis Using ¹⁸F-6-Fluoro-N-[2-(Diethylamino)Ethyl] Pyridine-3-Carboxamide, a Melanin-Specific PET Probe, by Perilesional Administration

Denoyer¹,

Potdevin²,

Roselt³

et al. 2010

J Nucl Med

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The efficacy of differing routes of administration of 18 F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide ( 18 F-MEL050), a new benzamide-based PET radiotracer for imaging regional lymph node metastasis in melanoma, was assessed. Methods: B16-Black/6 metastatic melanoma cells harboring an mCherry transgene were implanted into the left-upper-foot surface of 49 C57 Black/6 mice as a model of popliteal lymph node (PLN) metastasis. Ultrasound scanning of the left PLN was performed at baseline and in combination with 18 F-MEL050 PET on days 5, 9, and 14. Mice were divided into 2 groups to compare the results of tracer administration either subcutaneously at the tumor site (local) or in the lateral tail vein (systemic). After PET on each imaging day, 5 mice per group-including any with evidence of metastasis-were sacrificed for ex vivo validation studies including assessment of retained radioactivity and presence of the mCherry transgene as a surrogate of nodal tumor burden. Results: Nine mice were judged as positive for PLN metastasis by ultrasound at day 5, and 8 PLNs were positive on 18 F-MEL050 PET, 3 after systemic and 5 after local administration. Ex vivo analysis showed that ultrasound correctly identified 90% of positive PLNs, with 1 false-positive. 18 F-MEL050 PET correctly identified 60% of positive PLNs after systemic administration and 100% after local administration with no false-positive results by either route. The average node-to-background ratio for positive PLNs was 6.8 in the systemic-administration group and correlated with disease burden. In the local-administration group, the mean uptake ratio was 48, without clear relation to metastatic burden. Additional sites of metastatic disease were also correctly identified by 18 F-MEL050 PET. Conclusion: In addition to its potential for systemic staging, perilesional administration of 18 F-MEL050 may allow sensitive and specific, noninvasive identification of regional lymph node metastasis in pigmented malignant melanomas.

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Tests to assist in the staging of cutaneous melanoma: a generic protocol

Dinnes

Saleh

Newton‐Bishop

et al. 2017

Cochrane Database of Systematic Reviews

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This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To determine the diagnostic accuracy of SLNB for the detection of nodal metastases (in the investigated nodal basin) for the staging of cutaneous invasive melanoma. To determine the diagnostic accuracy of imaging tests for the detection of any metastasis in the primary staging of cutaneous invasive melanoma (i.e. staging at presentation). To determine the diagnostic accuracy of imaging tests for the detection of any metastasis in the staging of recurrence in cutaneous invasive melanoma (i.e. re-staging prompted by findings on routine follow-up). To determine the diagnostic accuracy of imaging tests for the detection of nodal metastases in the staging of cutaneous invasive melanoma. To determine the diagnostic accuracy of imaging tests for the detection of distant metastases in the staging of cutaneous invasive melanoma. These will be estimated separately for those undergoing primary staging and those who have experienced a disease recurrence. Investigation of sources of heterogeneity: We will consider a range of potential sources of heterogeneity for investigation in each individual test review. These may vary between reviews but may include the following. i. Population characteristics: * AJCC stage of disease * Sentinel lymph node status (for imaging studies only) * Clinical nodal status (for imaging studies only) * Primary tumour site (head and neck, trunk, limb, and other) ii. Index test characteristics: * Differences in test positivity thresholds (e.g. for SLNB, the tracer threshold for a 'hot' versus 'cold' node) * Other relevant test characteristics as appropriate to the test under consideration iii. Reference standard characteristics: * Reference standard used (histology, clinical or imaging-based follow-up; concurrent imaging-based reference standard) iv. Study quality: * Consecutive or random sample of participants recruited * Index test interpreted, blinded to the reference standard result * Index test interpreted, blinded to the result of any other index test * Presence of partial or differential verification bias (whereby only a sample of those subject to the index test are verified by the reference test or by the same reference test, with selection dependent on the index test result) * Use of an adequate reference standard * Overall risk of bias We will examine the quality and quantity of research evidence available on the effectiveness of each index test for the primary target condition and make recommendations regarding where further research might be required

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Staging of cutaneous melanoma

Cited by 83 publications

References 52 publications

Cáncer de piel: Una realidad cotidianamente ignorada.

Cáncer de piel: Una realidad cotidianamente ignorada.

Improved Detection of Regional Melanoma Metastasis Using ¹⁸F-6-Fluoro-N-[2-(Diethylamino)Ethyl] Pyridine-3-Carboxamide, a Melanin-Specific PET Probe, by Perilesional Administration

Tests to assist in the staging of cutaneous melanoma: a generic protocol

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Staging of cutaneous melanoma

Cited by 83 publications

References 52 publications

Cáncer de piel: Una realidad cotidianamente ignorada.

Cáncer de piel: Una realidad cotidianamente ignorada.

Improved Detection of Regional Melanoma Metastasis Using 18F-6-Fluoro-N-[2-(Diethylamino)Ethyl] Pyridine-3-Carboxamide, a Melanin-Specific PET Probe, by Perilesional Administration

Tests to assist in the staging of cutaneous melanoma: a generic protocol

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Improved Detection of Regional Melanoma Metastasis Using ¹⁸F-6-Fluoro-N-[2-(Diethylamino)Ethyl] Pyridine-3-Carboxamide, a Melanin-Specific PET Probe, by Perilesional Administration