Staging Hepatic Fibrosis: Comparison of Gadoxetate Disodium–enhanced and Diffusion-weighted MR Imaging—Preliminary Observations

Watanabe, Hidenobu; Kanematsu, Masayuki; Goshima, Satoshi; Kondo, Hiroshi; Onozuka, Minoru; Moriyama, Noriyuki; Bae, Kyongtae T.

doi:10.1148/radiol.10100621

Cited by 175 publications

(142 citation statements)

References 42 publications

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“…Several new methods, such as FibroScan, DWI, perfusion, gadoxetic acid-enhanced MRI, and magnetic resonance elastography (11)(12)(13)(14)(15)(16)(17)(18)(19)(20), are increasingly being used to assess liver fibrosis and have shown potential in predicting the severity of liver fibrosis. A previous multicenter prospective study showed that the diagnostic accuracy of FibroScan was high for cirrhosis but poor for significant fibrosis (F≥2) (11).…”

Section: Discussionmentioning

confidence: 99%

Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis

Yang¹,

Liang²,

Hu³

et al. 2016

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 99%

Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis

Yang¹,

Liang²,

Hu³

et al. 2016

Diagn Interv Radiol

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“…94 For example, because the liver enhancement ratio can, with some correction, be correlated with degree ofˆbrosis, this technique has been used to determine stage of liverˆbrosis. [95][96][97] The ratio of hepatocyte phase enhancement has also been used to assess local hepatic function. 98 Thus, non-morphological or quantitative MR imaging using gadoxetic acid as well as quantitative assessment using diŠusion-weighted and perfusion imaging may represent the new generation of projects.…”

Section: Quantitative Assessment Of Dišuse Liver Diseasementioning

confidence: 99%

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Ichikawa

Araki

2013

magn reson med sci

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Since its launch onto the world medical market, gadoxetic acid has received a great deal of attention from a diverse group of researchers, including gastroenterologists, hepatologists, and abdominal radiologists. Gadoxetic acid in liver magnetic resonance (MR) imaging might be considered to have excellent utility. However, several issues remain that radiologists should keep in mind when utilizing this product. We compiled this review to introduce gadoxetic acid, describe how it should be used, highlight the situations in which it is most and least reliable, and suggest potential avenues for future research.

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“…The diagnostic value of this technique on 1.5T MRI systems has been reported (4)(5)(6)(7)(8)(9). Data on the use of 3T systems in the evaluation of liver fibrosis are scarce (10,11). A higher magnetic field results in a higher signal, permitting higher resolution.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnostic value of 1.5 Tesla (T) magnetic resonance imaging (MRI) for the detection of parenchymal fibrosis has been published in some reports (4)(5)(6)(7)(8)(9). Only a few reports about the role of 3T MRI for determination of parenchymal fibrosis are present (10,11). There is only one study in the Chinese literature about ADC value changes in liver during nucleoside analogue antiviral treatment in patients with active hepatitis B virus (HBV) (12).…”

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confidence: 99%

Liver Apparent Diffusion Coefficient Changes during Telaprevir-Based Therapy for Chronic Hepatitis C

et al. 2016

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Background: Diffusion-weighted imaging (DWI) has become an established diagnostic modality for the evaluation of liver parenchymal changes in diseases such as diffuse liver fibrosis. Aims: To evaluate the parenchymal apparent diffusion coefficient value (ADC) changes using diffusion-weighted imaging (DWI) during telaprevir-based triple therapy. Study Design: Diagnostic accuracy study. Methods: Seventeen patients with chronic hepatitis C virus (HCV) virus and twenty-five normal volunteers were included. All of the patients took 12-weeks of telaprevir-based triple therapy followed by 12-weeks of PEGylated interferon and ribavirin therapy. They were examined before treatment (BT), as well as 12-weeks (W12) and 24-weeks (W24) after treatment by 3 Tesla magnetic resonance imaging (MRI). DWI was obtained using a breath-hold single-shot echoplanar spin echo sequence. Histopathologically, liver fibrosis was classified in accordance with the modified Knodell score described by Ishak. Quantitatively, liver ADCs were compared between patients and normal volunteers to detect the contribution of DWI in the detection of fibrosis. In addition, liver ADCs were compared during the therapy to analyze the effect of antiviral medication on liver parenchyma. Results:The liver ADC values of fibrotic liver parenchyma were significantly lower than those of the healthy liver parenchyma (p<0.001). However, we were not able to reach a sufficiently discriminative threshold value. The ADC values showed a declining trend with increasing fibrotic stage. No statistically significant correlation (p=0.204) was observed. Compared with those before treatment, the liver ADC values after telaprevir-based triple therapy were significantly decreased at W12. A significant increase in the liver ADC values was also observed after the cessation of telaprevir therapy at W24 with a return to initial values. Conclusion: Liver ADC values appear to indicate the present but not the stage of liver fibrosis. DWI may be a helpful research tool for the assessment of antiviral drug effects.

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Staging Hepatic Fibrosis: Comparison of Gadoxetate Disodium–enhanced and Diffusion-weighted MR Imaging—Preliminary Observations

Abstract: Gadoxetate disodium-enhanced MR imaging is more reliable for staging hepatic fibrosis than are diffusion-weighted MR imaging, hematologic, and clinical parameters.

Cited by 175 publications

References 42 publications

Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis

Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Liver Apparent Diffusion Coefficient Changes during Telaprevir-Based Therapy for Chronic Hepatitis C

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