Staging cutaneous squamous cell carcinoma metastases to the parotid gland

Czerwonka, Lukasz; Santis, R. J. De; Horowitz, Gilad; Hong, Michael; Orsini, Mario; Enepekides, Danny; Goldstein, David P.; Dort, J.; Higgins, Kevin

doi:10.1002/lary.26544

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…Nodal metastases of cutaneous squamous cell carcinoma to the parotid gland are by far the most frequent secondary metastasis within the parotid gland and the first differential diagnosis when histopathology reveals a squamous cell carcinoma in the parotid gland. About 15% of advanced (≥T2) cutaneous squamous cell carcinomas metastasize to regional lymph nodes in the parotid gland and/or neck ( 133 ). The most common location for the primary cutaneous cancer is ear/preauricular (about 39%), temple (19%), cheek (10%), scalp (10%), neck (7%), forehead (4%), lips (3%), and periorbital skin (2%).…”

Section: Resultsmentioning

confidence: 99%

“…The most common location for the primary cutaneous cancer is ear/preauricular (about 39%), temple (19%), cheek (10%), scalp (10%), neck (7%), forehead (4%), lips (3%), and periorbital skin (2%). If there is a parotid metastasis of cutaneous squamous cell carcinoma, about half of the patients have several intraparotid metastases ( 133 ). Further on, about two thirds of these patients show simultaneously a clinical negative neck (cN0 in the neck levels beyond the parotid) and one third a clinical positive neck (cN+).…”

Section: Resultsmentioning

confidence: 99%

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Contemporary Management of Benign and Malignant Parotid Tumors

Thielker

Grosheva

Ihrler³

et al. 2018

Front. Surg.

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To report the standard of care, interesting new findings and controversies about the treatment of parotid tumors.Relevant and actual studies were searched in PubMed and reviewed for diagnostics, treatment and outcome of both benign and malignant tumors.Prospective trials are lacking due to rarity of the disease and high variety of tumor subtypes.The establishment of reliable non-invasive diagnostics tools for the differentiation between benign and malignant tumors is desirable. Prospective studies clarifying the association between different surgical techniques for benign parotid tumors and morbidity are needed. The role of adjuvant or definitive radiotherapy in securing loco-regional control and improving survival in malignant disease is established. Prospective clinical trials addressing the role of chemotherapy/molecular targeted therapy for parotid cancer are needed. An international consensus on the classification of parotid surgery techniques would facilitate the comparison of different trials. Such efforts should lead into a clinical guideline.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Contemporary Management of Benign and Malignant Parotid Tumors

Thielker

Grosheva

Ihrler³

et al. 2018

Front. Surg.

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“…The parotid gland represents the most common salivary gland involved due to the presence of numerous intraparotid lymph nodes. Cutaneous SCCs located within the region of the ear, cheek, or temple are particularly at risk of metastasizing to parotid lymph node when their thickness exceeds 4 mm . Patients are usually elderly, with a mean age in the early 70s .…”

Section: Malignant Neoplasmsmentioning

confidence: 99%

“…Cutaneous SCCs located within the region of the ear, cheek, or temple are particularly at risk of metastasizing to parotid lymph node when their thickness exceeds 4 mm. 153,154 Patients are usually elderly, with a mean age in the early 70s. 151,155 The M : F ratio is roughly 2:1.…”

Section: Clear Cell Carcinomamentioning

confidence: 99%

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Lubin

Song

Zafar

et al. 2019

Diagnostic Cytopathology

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Oncocytic and oncocytoid lesions represent a distinct subset of salivary gland lesions. True oncocytic lesions of the salivary gland are entirely composed of oncocytes. These are characterized by the presence of abundant eosinophilic granules due to the presence of abundant cytoplasmic mitochondria. Oncocytic lesions of the salivary gland include oncocytosis, oncocytoma, and oncocytic carcinoma. In addition to the true oncocytic lesion, there exists another group of salivary gland lesions, which demonstrate cells with abundant and occasionally granular cytoplasm. These are often termed as “oncocytoid” lesions. The recently proposed Milan System for reporting salivary gland cytology clearly states that fine‐needle aspiration specimens representing oncocytic/oncocytoid lesions of salivary gland cannot effectively distinguish between a nonneoplastic lesion, benign and malignant neoplasms. Therefore, most lesions lacking classic cytomorphologic features will be classified under the umbrella diagnostic term of “Salivary Gland Neoplasm of Uncertain Malignant Potential” (SUMP). In this review, we discuss and illustrate key clinicopathologic and radiologic features that can help the practicing cytopathologist narrow down the differential and provide the best management based diagnosis.

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“…Previous evidence has shown that approximately 15% of advanced (≥T2) cSCC have been found to have regional lymph nodes metastasis in parotid gland or neck ( 5 ). The frequency of location for primary cutaneous SCC in descending order is: ear/preauricular (about 39%), temple (19%), cheek (10%), scalp (10%), neck (7%), forehead (4%), lips (3%), and periorbital skin (2%) ( 8 ). Czerwonka et al have shown that up to thirty percent of patients with cSCC have presented with parotid metastases upon diagnosis of cutaneous primary, while 70% have developed nodal metastases following management of their cutaneous primary ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous squamous cell carcinoma with secondary parotid metastasis: a case report

Liang¹,

Cheng²,

Sulaiman³

et al. 2023

AME Case Rep

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Background Majority of cutaneous squamous cell carcinoma (cSCC) originate in the head and neck region, with 1–3% have been found to have parotid or periparotid lymph nodes metastases. The significance of secondary parotid metastases from cSCC lies in its propensity of cervical lymph node spread and distant metastases leading to a dismal prognosis, and therefore the importance of early diagnosis and prompt treatment. Case Description An 85-year-old gentleman with prior history of right temporal squamous cell carcinoma (SCC) presented with a new onset left cheek cSCC. He underwent complete excision with clear margin. Four months following initial surgery, he developed ulcerative mass at left angle of mandible. CT scan revealed an underlying left parotid gland tumor, which was confirmed to be SCC by fine needle aspiration cytology (FNAC). He was then surgically treated with nerve-sparing total parotidectomy, modified radical neck dissection, soft tissue reconstruction using free anterolateral thigh fasciocutaneous flap and adjuvant radiotherapy with satisfactory outcomes. Conclusions Although rare, metastatic cutaneous SCC to parotid gland represents a unique group of locally advanced cutaneous SCC. Multimodal treatment approach consisting of total parotidectomy, ipsilateral neck dissection and adjuvant radiotherapy has been shown to improve the locoregional control of the disease and limit the propensity to distant metastasis.

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Staging cutaneous squamous cell carcinoma metastases to the parotid gland

Abstract: 4. Laryngoscope, 127:2063-2069, 2017.

Cited by 9 publications

References 11 publications

Contemporary Management of Benign and Malignant Parotid Tumors

Contemporary Management of Benign and Malignant Parotid Tumors

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Cutaneous squamous cell carcinoma with secondary parotid metastasis: a case report

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