Stages III and IV squamous cell carcinoma of the mouth: Three-year experience with superselective intraarterial chemotherapy using cisplatin prior to definitive treatment

Abstract

Early tumor reduction without delay of subsequent treatments can be obtained by intraarterial chemotherapy while minimizing complications and possibly improving survival. Further investigations of long-term survival with larger series need to be performed.

Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in134 cases

“…Currently, surgery is the standard treatment (Poulsen et al, 1996). Several studies have reported arterial injection therapy for oral cavity cancer; however, the number of patients in such studies tended to be small, and its usefulness has not yet been clearly (Hirai et al, 1999;Damascelli et al, 2003;Kovacs, 2004). No randomised controlled trials have yet been performed to compare the effectiveness of surgery with chemoradiation, and the usefulness of chemoradiation therapy involving systemic chemotherapy thus remains to be clarified.…”

A Cone-Beam Volume CT Using a 3D Angiography System with a Flat Panel Detector of Direct Conversion Type: Usefulness for Superselective Intra-arterial Chemotherapy for Head and Neck Tumors

“…Previous reports have described the complications associated with intra-arterial chemotherapy for cancers of the head and neck. [2][3][4] The local toxicity of the chemotherapy agent includes mucositis, dermatitis, skin necrosis, and peripheral and cranial nerve palsies. When the tumor was not enhanced on cone-beam CT, which occurred in 2 of 43 arteries, our interventional radiologists did not perform the superselective intra-arterial chemotherapy.…”

“…Recent advances in the therapeutic techniques of interventional radiology, including the development of some types of microcatheters, now enable us to perform superselective arterial infusion to head and neck structures. [1][2][3][4] Because conventional digital subtraction angiography (DSA) provides only 2D projections of the vascular anatomy, however, the identification of the tumor feeding artery is occasionally difficult due to the presence of a complex anatomy or multiple feeding arteries. In addition, staining of head and neck tumors is not always observed on DSA.…”

Evaluation of vascular supply with cone-beam computed tomography during intraarterial chemotherapy for a skull base tumor

“…[1][2][3][4] With this procedure, it is essential that the anticancer agent be administered effectively into the tumor vessels. Angiography is used to identify tumor vessels, but their precise identification is sometimes difficult with angiography alone in cases with poor tumor staining or if there are multiple feeding vessels.…”