Stage-specific frequency and prognostic significance of aneuploidy in patients with sporadic colorectal cancer—a meta-analysis and current overview

Laubert, Tilman; Freitag‐Wolf, Sandra; Linnebacher, Michael; König, Alexandra; Vollmar, Brigitte; Habermann, Jens K.

doi:10.1007/s00384-015-2259-x

Cited by 19 publications

(18 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CRC may be staged according to the American Joint Committee of Cancer tumor node metastasis or Dukes staging system ( 3 , 4 ). Dukes A/B and UICC I/II are considered early-stage CRC, Dukes C/D and UICC III/IV are considered late-stage CRC ( 5 ). Surgical removal is the optimal treatment choice for CRC when detected early, but is often diagnosed too late, whereby the only feasible treatment option left is drugs.…”

Section: Introductionmentioning

confidence: 99%

COL1A1: A potential therapeutic target for colorectal cancer expressing wild-type or mutant KRAS

et al. 2018

View full text Add to dashboard Cite

Colorectal cancer (CRC) treatment primarily relies on chemotherapy along with surgery, radiotherapy and, more recently, targeted therapy at the late stages. However, chemotherapeutic drugs have high cytotoxicity, and the similarity between the effects of these drugs on cancerous and healthy cells limits their wider use in clinical settings. Targeted monoclonal antibody treatment may compensate for this deficiency. Epidermal growth factor receptor (EGFR)-targeted drugs have a positive effect on CRC with intact KRAS proto-oncogene GTPase (KRAS or KRASWT), but may be ineffective or harmful in patients with KRAS mutations (KRASMUT). Therefore, it is important to identify drug target genes that are uniformly effective with regards to KRASWT and KRASMUT CRC. The present study performed gene expression analysis, and identified 294 genes upregulated in KRASWT and KRASMUT CRC samples. Collagen type I α 1 (COL1A1) was identified as the hub gene through STRING and Cytoscape analyses. Consistent with results obtained from Oncomine, a cancer microarray database and web-based data-mining platform, it was demonstrated that the expression of COL1A1 was significantly upregulated in CRC tissues and cell lines regardless of KRAS status. Inhibition of COL1A1 in KRASWT and KRASMUT CRC cell lines significantly decreased cell proliferation and invasion. In addition, increased COL1A1 expression in CRC was significantly associated with serosal invasion, lymph metastases and hematogenous metastases. Taken together, the findings of the present study indicated that COL1A1 may serve as a candidate diagnostic biomarker and a promising therapeutic target for CRC.

show abstract

Section: Introductionmentioning

confidence: 99%

COL1A1: A potential therapeutic target for colorectal cancer expressing wild-type or mutant KRAS

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Combining DNA ploidy and the deletion status, both arising from genetic instability, were markedly powerful predictors of poor prognosis (Lennartz et al 2016). So too in colorectal tumours aneuploidy has been linked with advanced Duke stage and found to be predictive of prognosis (Laubert et al 2015). Alexiou et al (2013) investigated the intracranial tumours and Cell cycle analyses and SPF determinations differed markedly between low grade and high grade gliomas.…”

Section: The Connotation Of Er and Pr On Dna Ploidy Spf And Cell Cycmentioning

confidence: 99%

Does DNA ploidy and synthesis phase dynamic accentuate the predictive power of oestrogen and progesterone receptors in breast cancer progression and prognosis?

Sherbet¹,

Dlay²

2018

Atlas of Genetics and Cytogenetics in Oncology and Haematology

View full text Add to dashboard Cite

Oestrogen and progesterone receptors (ER and PR) are closely associated with breast cancer progression. In this review we identify and discuss cellular markers that can accentuate or complement the deployment of ER and PR for predicting prognosis. The focus is on aneuploidy and DNA ploidy which appear to be significant independent predictors of overall survival in many forms of cancer. Their importance in cancer development and progression flows from their origin in the inherent genetic instability. Genetic instability of chromosomes is seen as aneuploidy, chromosomal deletions, translocations and sister-chromatid recombination, and at the DNA level as altered DNA repair, gene amplification and deletion and point mutations. Microsatellite loci of repetitive nucleotide sequences are inherently unstable. Microsatellite instability is characterised by the loss of DNA mismatch repair activity leading to a hypermutable phenotype. Chromosome abnormalities result from the deregulation of cell cycle and immune checkpoint regulators. Failure of Oestrogen and progesterone receptors in breast cancer

show abstract

“…Oversikt over arbeider der man har studert den prognostiske verdien av DNA-ploidianalyse for pasienter med tykktarmskarsinom (2000 -16 I tillegg er det i tre store metaanalyser, som alle inkluderte over 5 000 pasienter (7,48,49), konkludert med at pasienter med aneuploide svulster har signifikant lavere femårsoverlevelse (hasardratio 1,45) enn pasienter med diploide svulster (48,49). Videre er det observert en mortalitetsreduksjon på >15 % for pasienter med diploide svulster (48) og sammenheng mellom aneuploiditet og mer avanserte kreftstadier (7).…”

Section: Tabellunclassified

Egenskaper ved kreftcellenes DNA påvirker prognosen

et al. 2017

View full text Add to dashboard Cite

Stage-specific frequency and prognostic significance of aneuploidy in patients with sporadic colorectal cancer—a meta-analysis and current overview

Abstract: A substantial number of studies showed a prognostic importance of aneuploidy in CRC. Furthermore, the higher frequency of aneuploidy in late-stage CRC implies an increase in genomic instability with CRC progression, indicating aneuploidy to be also a stage-specific prognostic marker.

Cited by 19 publications

References 76 publications

COL1A1: A potential therapeutic target for colorectal cancer expressing wild-type or mutant KRAS

COL1A1: A potential therapeutic target for colorectal cancer expressing wild-type or mutant KRAS

Does DNA ploidy and synthesis phase dynamic accentuate the predictive power of oestrogen and progesterone receptors in breast cancer progression and prognosis?

Egenskaper ved kreftcellenes DNA påvirker prognosen

Contact Info

Product

Resources

About