2003
DOI: 10.1053/ejso.2002.1401
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Stage migration in breast cancer: surgical decisions concerning isolated tumour cells and micro-metastases in the sentinel lymph node

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Cited by 33 publications
(12 citation statements)
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“…Although axillary lymph node dissection (ALND) is still standard of care in any case of SLN metastasis [2][3][4][5][6][7][8], there is an ongoing debate about the necessity for complete ALND in every patient with metastatic SLN, especially in those with little risk of additional disease since 40-60% of patients have no disease in axillary lymph node other than SLN itself [1,9,10]. These patients, therefore, are unlikely to benefit from further surgery that results in a longer period of hospitalization, higher costs and higher postoperative morbidity [11].…”
Section: Introductionmentioning
confidence: 99%
“…Although axillary lymph node dissection (ALND) is still standard of care in any case of SLN metastasis [2][3][4][5][6][7][8], there is an ongoing debate about the necessity for complete ALND in every patient with metastatic SLN, especially in those with little risk of additional disease since 40-60% of patients have no disease in axillary lymph node other than SLN itself [1,9,10]. These patients, therefore, are unlikely to benefit from further surgery that results in a longer period of hospitalization, higher costs and higher postoperative morbidity [11].…”
Section: Introductionmentioning
confidence: 99%
“…Regarding SLN micrometastases and relation to clinical outcome, there is limited data based on retrospective examination by IHC of the SLN (9). Patients with ITC are recommended adjuvant treatment as node-negative patients (2), whereas the role of ALND in this group of patients is still under debate since the risk of additional axillary nodal involvement is yet not clarified (10, 11,12,13).…”
Section: Introductionmentioning
confidence: 99%
“…10 This increase could have an important effect on the treatment of patients. 11,12 Based on the Dutch treatment guidelines, most patients with small tumours and negative nodes will not be treated with adjuvant therapy, while patients staged with metastases will receive adjuvant treatment. It is not yet clear whether patients with micrometastases should be treated as node positive or negative.…”
Section: Introductionmentioning
confidence: 99%