Abstract:Small cell carcinoma (SCC) of the endometrium is a rare but aggressive disease with early systemic involvement. Patient survival is short. To date, no effective treatment protocol has been established. Surgery, radiotherapy, and chemotherapy have been used either alone or in combination. The case of a patient with stage IB endometrial SCC is presented with an overview based on all reported cases of SCC of the endometrium and its treatment with particular reference to stage I cases.
“…There were no symptoms of paraneoplastic syndrome in the three cases presented here. Among the 80 cases of endometrial SCC that have been reported up to now, more than half of the patients with available data had stage III and IV disease (6). Two of the patients reported here had stage III and IV disease.…”
Section: Discussionmentioning
confidence: 91%
“…The diagnosis of SCC of the endometrium needs evidence of endometrial origin, dense sheet-like growth of morphologically similar small tumour cells and immunohistochemical staining for at least one neuroendocrine marker (4). Some of the most common neuroendocrine markers that have been reported to be positive in these tumours are NSE, synaptophysin, chromogranin A and cytokeratin (1,5,6). In the first case, the tumour cells were strongly and diffusely positive for NSE, strongly and focally positive for pancytokeratin and LMWCK and negative for synaptophysin, chromogranin A and S100.…”
“…There were no symptoms of paraneoplastic syndrome in the three cases presented here. Among the 80 cases of endometrial SCC that have been reported up to now, more than half of the patients with available data had stage III and IV disease (6). Two of the patients reported here had stage III and IV disease.…”
Section: Discussionmentioning
confidence: 91%
“…The diagnosis of SCC of the endometrium needs evidence of endometrial origin, dense sheet-like growth of morphologically similar small tumour cells and immunohistochemical staining for at least one neuroendocrine marker (4). Some of the most common neuroendocrine markers that have been reported to be positive in these tumours are NSE, synaptophysin, chromogranin A and cytokeratin (1,5,6). In the first case, the tumour cells were strongly and diffusely positive for NSE, strongly and focally positive for pancytokeratin and LMWCK and negative for synaptophysin, chromogranin A and S100.…”
“…The diagnosis of primary small cell neuroendocrine carcinoma of the endometrium primarily relies upon immunohistochemical studies discerning neuroendocrine differentiation [8, 9]. Histopathologically, the disease is characterized by small tumor cells exhibiting sheet-like growth of endometrial origin [8].…”
Section: Introductionmentioning
confidence: 99%
“…Histopathologically, the disease is characterized by small tumor cells exhibiting sheet-like growth of endometrial origin [8]. …”
Section: Introductionmentioning
confidence: 99%
“…Despite reported clinical and pathologic data, only scant clinical data are available to elucidate this disease's behavior and optimal management [1, 2, 4, 8]. We describe a very rare case involving a patient diagnosed with and treated for primary small cell neuroendocrine carcinoma of the endometrium.…”
Background: Small cell neuroendocrine carcinoma is very rarely encountered within the endometrium. Case Study: A patient underwent a hysterectomy and salpingo-oophorectomy for a suspicious gynecologic condition. Pathology revealed invasive small cell neuroendocrine carcinoma of the endometrium; the neoplasm exhibited positive immunoreactivity for synaptophysin, pancytokeratin and CD56 but was negative for CD3 and CD20. Prior to chemotherapy, a completion lymphadenectomy was indicated to determine the presence of nodal metastases. Conclusion: The prognosis of small cell neuroendocrine carcinoma of the endometrium is unfavorable but prompt detection with surgery and adjuvant therapy may confer a better clinical outcome.
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